Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review
Article Category: Review
Published Online: Sep 17, 2023
Page range: 45 - 54
DOI: https://doi.org/10.2478/abm-2023-0044
Keywords
© 2023 Jiansheng Zheng et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Background
Inflammatory bowel disease (IBD) is a condition with an unclear genetic basis. Fucosyltransferase 3 (FUT3) could potentially be linked to IBD susceptibility.
Objective
To investigate the association between
Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist and Population, Intervention, Comparison, Outcomes, and Study (PICOS) guidelines, case-control studies published until April 30, 2020 was searched. Two independent reviewers conducted screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale. Meta-analysis, sensitivity analysis, and Egger tests were performed using RevMan and Stata12.0.
Results
The review included 5 articles and 12 case-control studies involving 1712 IBD patients and 1903 controls. The meta-analysis revealed the following combined odds ratios [95% confidence intervals]:
Conclusions
The