Sialic acid: an attractive biomarker with promising biomedical applications

[1] Park SS. Post-glycosylation modification of sialic acid and its role in virus pathogenesis. Vaccines (Basel). 2019; 7:171. doi: 10.3390/vaccines7040171 ParkSS Post-glycosylation modification of sialic acid and its role in virus pathogenesis Vaccines (Basel) 2019 7 171 10.3390/vaccines7040171 696318931683930 Open DOISearch in Google Scholar

[2] Zhang C, Chen J, Liu Y, Xu D. Sialic acid metabolism as a potential therapeutic target of atherosclerosis. Lipids Health Dis. 2019; 18:173. doi: 10.1186/s12944-019-1113-5 ZhangC ChenJ LiuY XuD Sialic acid metabolism as a potential therapeutic target of atherosclerosis Lipids Health Dis 2019 18 173 10.1186/s12944-019-1113-5 674506131521172 Open DOISearch in Google Scholar

[3] Schauer R, Kamerling JP. Exploration of the sialic acid world. In: Baker DC, editor. Sialic acids, Part I: Historical background and development, and chemical synthesis. San Diego: Academic Press; 2018, p. 1–213. (Demchenko A, Knirel YA, Stütz AE, Vliegenthart JFG, Yu B, series advisors. Adv Carbohydr Chem Biochem., vol. 75). SchauerR KamerlingJP Exploration of the sialic acid world In: BakerDC editor. Sialic acids, Part I: Historical background and development, and chemical synthesis San Diego Academic Press 2018 1 213 (Demchenko A, Knirel YA, Stütz AE, Vliegenthart JFG, Yu B, series advisors. Adv Carbohydr Chem Biochem., vol. 75). 10.1016/bs.accb.2018.09.001711206130509400 Search in Google Scholar

[4] Roozbeh J, Merat A, Bodagkhan F, Afshariani R, Yarmohammadi H. Significance of serum and urine neuraminidase activity and serum and urine level of sialic acid in diabetic nephropathy. Int Urol Nephrol. 2011; 43:1143–8. RoozbehJ MeratA BodagkhanF AfsharianiR YarmohammadiH Significance of serum and urine neuraminidase activity and serum and urine level of sialic acid in diabetic nephropathy Int Urol Nephrol 2011 43 1143 8 10.1007/s11255-010-9891-821207147 Search in Google Scholar

[5] Zhu Z, Cai T, Fan L, Lou K, Hua X, Huang Z, Gao G. Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019. Int J Infect Dis. 2020; 95:332–9. ZhuZ CaiT FanL LouK HuaX HuangZ GaoG Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019 Int J Infect Dis 2020 95 332 9 10.1016/j.ijid.2020.04.041719500332334118 Search in Google Scholar

[6] Matrosovich M, Herrler G, Klenk HD. Sialic acid receptors of viruses. In: Gerardy-Schahn R, Delannoy P, von Itzstein M, editors. Sialoglyco chemistry and biology II: tools and techniques to identify and capture sialoglycans. Heidelberg: Springer-Verlag; 2015, p. 1–28. (H. Bayley H, Houk KN, Hughes G, Hunter CA, Ishihara K, M.J. Krische MJ, et al., series editors. Top Curr Chem., vol. 367). MatrosovichM HerrlerG KlenkHD Sialic acid receptors of viruses In: Gerardy-SchahnR DelannoyP von ItzsteinM editors. Sialoglyco chemistry and biology II: tools and techniques to identify and capture sialoglycans Heidelberg Springer-Verlag 2015 1 28 (H. Bayley H, Houk KN, Hughes G, Hunter CA, Ishihara K, M.J. Krische MJ, et al., series editors. Top Curr Chem., vol. 367). 10.1007/128_2013_466712018323873408 Search in Google Scholar

[7] Wasik BR, Barnard KN, Parrish CR. Effects of sialic acid modifications on virus binding and infection. Trends Microbiol. 2016; 24:991–1001. WasikBR BarnardKN ParrishCR Effects of sialic acid modifications on virus binding and infection Trends Microbiol 2016 24 991 1001 10.1016/j.tim.2016.07.005512396527491885 Search in Google Scholar

[8] von Itzstein M., editor. Influenza virus sialidase – A drug discovery target. Basel: Springer; 2014, p. 1–178. (Parnham MJ, Bruinvels J., series editors., Milestones Drug Ther.). von ItzsteinM. editor. Influenza virus sialidase – A drug discovery target Basel Springer 2014 1 178 (Parnham MJ, Bruinvels J., series editors., Milestones Drug Ther.). Search in Google Scholar

[9] Wu NC, Wilson IA. Structural biology of influenza hemagglutinin: an amaranthine adventure. Viruses. 2020; 12:1053. doi: 10.3390/v12091053 WuNC WilsonIA Structural biology of influenza hemagglutinin: an amaranthine adventure Viruses 2020 12 1053 10.3390/v12091053 755119432971825 Open DOISearch in Google Scholar

[10] Benton DJ, Wharton SA, Martin SR, McCauley JW. Role of neuraminidase in influenza A(H7N9) virus receptor binding. J Virol. 2017; 91:e02293–16. doi: 10.1128/jvi.02293-16 BentonDJ WhartonSA MartinSR McCauleyJW Role of neuraminidase in influenza A(H7N9) virus receptor binding J Virol 2017 91 e02293 16 10.1128/jvi.02293-16 Open DOISearch in Google Scholar

[11] Wen F, Wan X-F. Influenza neuraminidase: underrated role in receptor binding. Trends Microbiol. 2019; 27:477–9. WenF WanX-F Influenza neuraminidase: underrated role in receptor binding Trends Microbiol 2019 27 477 9 10.1016/j.tim.2019.03.001652746530930001 Search in Google Scholar

[12] Imai M, Kawaoka Y. The role of receptor binding specificity in interspecies transmission of influenza viruses. Curr Opin Virol. 2012; 2:160–7. ImaiM KawaokaY The role of receptor binding specificity in interspecies transmission of influenza viruses Curr Opin Virol 2012 2 160 7 10.1016/j.coviro.2012.03.003 Search in Google Scholar

[13] Matrosovich M, Tuzikov A, Bovin N, Gambaryan A, Klimov A, Castrucci MR, et al. Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals. J Virol. 2000; 74:8502–12. MatrosovichM TuzikovA BovinN GambaryanA KlimovA CastrucciMR Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals J Virol 2000 74 8502 12 10.1128/JVI.74.18.8502-8512.2000 Search in Google Scholar

[14] Rogers GN, Paulson JC. Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology. 1983; 127:361–73. RogersGN PaulsonJC Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin Virology 1983 127 361 73 10.1016/0042-6822(83)90150-2 Search in Google Scholar

[15] Connor RJ, Kawaoka Y, Webster RG, Paulson JC. Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates. Virology. 1994; 205:17–23. ConnorRJ KawaokaY WebsterRG PaulsonJC Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates Virology 1994 205 17 23 10.1006/viro.1994.16157975212 Search in Google Scholar

[16] Wang M, Veit M. Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus. Protein Cell. 2016; 7:28–45. WangM VeitM Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus Protein Cell 2016 7 28 45 10.1007/s13238-015-0193-x470715526215728 Search in Google Scholar

[17] Kim C-H. SARS-CoV-2 Evolutionary adaptation toward host entry and recognition of receptor O-acetyl sialylation in virus-host interaction. Int J Mol Sci. 2020; 21:4549. doi: 10.3390/ijms21124549 KimC-H SARS-CoV-2 Evolutionary adaptation toward host entry and recognition of receptor O-acetyl sialylation in virus-host interaction Int J Mol Sci 2020 21 4549 10.3390/ijms21124549 735254532604730 Open DOISearch in Google Scholar

[18] Bolton MJ, Ort JT, McBride R, Swanson NJ, Wilson J, Awofolaju M, et al. Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021–22 Northern Hemisphere influenza season. Cell Rep. 2022; 39:110897. doi: 10.1016/j.celrep.2022.110897 BoltonMJ OrtJT McBrideR SwansonNJ WilsonJ AwofolajuM Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021–22 Northern Hemisphere influenza season Cell Rep 2022 39 110897 10.1016/j.celrep.2022.110897 915308335649381 Open DOISearch in Google Scholar

[19] Klausegger A, Strobl B, Regl G, Kaser A, Luytjes W, Vlasak R. Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus. J Virol. 1999; 73:3737–43. KlauseggerA StroblB ReglG KaserA LuytjesW VlasakR Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus J Virol 1999 73 3737 43 10.1128/JVI.73.5.3737-3743.199910415010196267 Search in Google Scholar

[20] Smits SL, Gerwig GJ, van Vliet AL, Lissenberg A, Briza P, Kamerling JP, et al. Nidovirus sialate-O-acetylesterases: evolution and substrate specificity of coronaviral and toroviral receptor-destroying enzymes. J Biol Chem. 2005; 280:6933–41. SmitsSL GerwigGJ van VlietAL LissenbergA BrizaP KamerlingJP Nidovirus sialate-O-acetylesterases: evolution and substrate specificity of coronaviral and toroviral receptor-destroying enzymes J Biol Chem 2005 280 6933 41 10.1074/jbc.M409683200806279315507445 Search in Google Scholar

[21] Markwell MA, Svennerholm L, Paulson JC. Specific gangliosides function as host cell receptors for Sendai virus. Proc Natl Acad Sci U S A. 1981; 78:5406–10. MarkwellMA SvennerholmL PaulsonJC Specific gangliosides function as host cell receptors for Sendai virus Proc Natl Acad Sci U S A 1981 78 5406 10 10.1073/pnas.78.9.54063487546272300 Search in Google Scholar

[22] Suzuki T, Portner A, Scroggs RA, Uchikawa M, Koyama N, Matsuo K, et al. Receptor specificities of human respiroviruses. J Virol. 2001; 75:4604–13. SuzukiT PortnerA ScroggsRA UchikawaM KoyamaN MatsuoK Receptor specificities of human respiroviruses J Virol 2001 75 4604 13 10.1128/JVI.75.10.4604-4613.2001 Search in Google Scholar

[23] Palese P, Tobita K, Ueda M, Compans RW. Characterization of temperature sensitive influenza virus mutants defective in neuraminidase. Virology. 1974; 61:397–410. PaleseP TobitaK UedaM CompansRW Characterization of temperature sensitive influenza virus mutants defective in neuraminidase Virology 1974 61 397 410 10.1016/0042-6822(74)90276-1 Search in Google Scholar

[24] Vlasak R, Luytjes W, Spaan W, Palese P. Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses. Proc Natl Acad Sci U S A. 1988; 85:4526–9. VlasakR LuytjesW SpaanW PaleseP Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses Proc Natl Acad Sci U S A 1988 85 4526 9 10.1073/pnas.85.12.45262804633380803 Search in Google Scholar

[25] Heida R, Bhide YC, Gasbarri M, Kocabiyik Ö, Stellacci F, Huckriede ALW, et al. Advances in the development of entry inhibitors for sialic-acid-targeting viruses. Drug Discov Today. 2021; 26:122–37. HeidaR BhideYC GasbarriM KocabiyikÖ StellacciF HuckriedeALW Advances in the development of entry inhibitors for sialic-acid-targeting viruses Drug Discov Today 2021 26 122 37 10.1016/j.drudis.2020.10.009757731633099021 Search in Google Scholar

[26] Qing E, Hantak M, Perlman S, Gallagher T. Distinct roles for sialoside and protein receptors in coronavirus infection. mBio. 2020; 11:e02764–19. doi: 10.1128/mBio.02764-19 QingE HantakM PerlmanS GallagherT Distinct roles for sialoside and protein receptors in coronavirus infection mBio 2020 11 e02764 19 10.1128/mBio.02764-19 701865832047128 Open DOISearch in Google Scholar

[27] Munkley J, Scott E. Targeting aberrant sialylation to treat cancer. Medicines (Basel). 2019; 6:102. doi: 10.3390/medicines6040102 MunkleyJ ScottE Targeting aberrant sialylation to treat cancer Medicines (Basel) 2019 6 102 10.3390/medicines6040102 696394331614918 Open DOISearch in Google Scholar

[28] Daly J, Carlsten M, O’Dwyer M. Sugar free: novel immunotherapeutic approaches targeting Siglecs and sialic acids to enhance natural killer cell cytotoxicity against cancer. Front Immunol. 2019; 10:1047. doi: 10.3389/fimmu.2019.01047 DalyJ CarlstenM O’DwyerM Sugar free: novel immunotherapeutic approaches targeting Siglecs and sialic acids to enhance natural killer cell cytotoxicity against cancer Front Immunol 2019 10 1047 10.3389/fimmu.2019.01047 652179731143186 Open DOISearch in Google Scholar

[29] Glavey SV, Manier S, Natoni A, Sacco A, Moschetta M, Reagan MR, et al. The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma. Blood. 2014; 124:1765–76. GlaveySV ManierS NatoniA SaccoA MoschettaM ReaganMR The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma Blood 2014 124 1765 76 10.1182/blood-2014-03-560862416210725061176 Search in Google Scholar

[30] Chang L-Y, Liang S-Y, Lu S-C, Tseng HC, Tsai H-Y, Tang C-J, et al. Molecular basis and role of Siglec-7 ligand expression on chronic lymphocytic leukemia B cells. Front Immunol. 2022; 13:840388. doi: 10.3389/fimmu.2022.840388 ChangL-Y LiangS-Y LuS-C TsengHC TsaiH-Y TangC-J Molecular basis and role of Siglec-7 ligand expression on chronic lymphocytic leukemia B cells Front Immunol 2022 13 840388 10.3389/fimmu.2022.840388 919529435711441 Open DOISearch in Google Scholar

[31] Miyagi T. Aberrant expression of sialidase and cancer progression. Proc Jpn Acad Ser B Phys Biol Sci. 2008; 84:407–18. MiyagiT Aberrant expression of sialidase and cancer progression Proc Jpn Acad Ser B Phys Biol Sci 2008 84 407 18 10.2183/pjab.84.407372054519075514 Search in Google Scholar

[32] Topham NJ, Hewitt EW. Natural killer cell cytotoxicity: how do they pull the trigger? Immunology. 2009; 128:7–15. TophamNJ HewittEW Natural killer cell cytotoxicity: how do they pull the trigger? Immunology 2009 128 7 15 10.1111/j.1365-2567.2009.03123.x274713419689731 Search in Google Scholar

[33] Paust S, Senman B, von Andrian UH. Adaptive immune responses mediated by natural killer cells. Immunol Rev. 2010; 235:286–96. PaustS SenmanB von AndrianUH Adaptive immune responses mediated by natural killer cells Immunol Rev 2010 235 286 96 10.1111/j.0105-2896.2010.00906.x291163320536570 Search in Google Scholar

[34] Shao J-Y, Yin W-W, Zhang Q-F, Liu Q, Peng M-L, Hu H-D, et al. Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities. Scand J Immunol. 2016; 84:182–90. ShaoJ-Y YinW-W ZhangQ-F LiuQ PengM-L HuH-D Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities Scand J Immunol 2016 84 182 90 10.1111/sji.1245527312286 Search in Google Scholar

[35] Lübbers J, Rodríguez E, van Kooyk Y. Modulation of immune tolerance via Siglec-sialic acid interactions. Front Immunol. 2018; 9:2807. doi: 10.3389/fimmu.2018.02807 LübbersJ RodríguezE van KooykY Modulation of immune tolerance via Siglec-sialic acid interactions Front Immunol 2018 9 2807 10.3389/fimmu.2018.02807 629387630581432 Open DOISearch in Google Scholar

[36] Varchetta S, Mele D, Oliviero B, Mantovani S, Ludovisi S, Cerino A, et al. Unique immunological profile in patients with COVID-19. Cell Mol Immunol. 2021; 18:604–12. VarchettaS MeleD OlivieroB MantovaniS LudovisiS CerinoA Unique immunological profile in patients with COVID-19 Cell Mol Immunol 2021 18 604 12 10.1038/s41423-020-00557-9755723033060840 Search in Google Scholar

[37] Häuselmann I, Borsig L. Altered tumor-cell glycosylation promotes metastasis. Front Oncol. 2014; 4:28. doi: 10.3389/fonc.2014.00028 HäuselmannI BorsigL Altered tumor-cell glycosylation promotes metastasis Front Oncol 2014 4 28 10.3389/fonc.2014.00028 392313924592356 Open DOISearch in Google Scholar

[38] Yang H, Lu L, Chen X. An overview and future prospects of sialic acids. Biotechnol Adv. 2021; 46:107678. doi: 10.1016/j.biotechadv.2020.107678 YangH LuL ChenX An overview and future prospects of sialic acids Biotechnol Adv 2021 46 107678 10.1016/j.biotechadv.2020.107678 33285252 Open DOISearch in Google Scholar

[39] Fuster MM, Esko JD. The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer. 2005; 5:526–42. FusterMM EskoJD The sweet and sour of cancer: glycans as novel therapeutic targets Nat Rev Cancer 2005 5 526 42 10.1038/nrc164916069816 Search in Google Scholar

[40] Kajander T, Lehtinen MJ, Hyvärinen S, Bhattacharjee A, Leung E, Isenman DE, et al. Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc Natl Acad Sci U S A. 2011; 108:2897–902. KajanderT LehtinenMJ HyvärinenS BhattacharjeeA LeungE IsenmanDE Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement Proc Natl Acad Sci U S A 2011 108 2897 902 10.1073/pnas.1017087108304113421285368 Search in Google Scholar

[41] Kim Y-H, Min KH, Wang Z, Kim J, Jacobson O, Huang P, et al. Development of sialic acid-coated nanoparticles for targeting cancer and efficient evasion of the immune system. Theranostics. 2017; 7:962–73. KimY-H MinKH WangZ KimJ JacobsonO HuangP Development of sialic acid-coated nanoparticles for targeting cancer and efficient evasion of the immune system Theranostics 2017 7 962 73 10.7150/thno.19061538125828382168 Search in Google Scholar

[42] Chen Z, Yu M, Guo L, Zhang B, Liu S, Zhang W, et al. Tumor derived SIGLEC family genes may play roles in tumor genesis, progression, and immune microenvironment regulation. Front Oncol. 2020; 10:586820. doi: 10.3389/fonc.2020.586820 ChenZ YuM GuoL ZhangB LiuS ZhangW Tumor derived SIGLEC family genes may play roles in tumor genesis, progression, and immune microenvironment regulation Front Oncol 2020 10 586820 10.3389/fonc.2020.586820 768100333240817 Open DOISearch in Google Scholar

[43] Huang P-J, Low P-Y, Wang I, Hsu S-TD, Angata T. Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses. J Biol Chem. 2018; 293:19645–58. HuangP-J LowP-Y WangI HsuS-TD AngataT Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses J Biol Chem 2018 293 19645 58 10.1074/jbc.RA118.005676631413730377253 Search in Google Scholar

[44] Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nat Med. 2019; 25:656–66. WangJ SunJ LiuLN FliesDB NieX TokiM Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy Nat Med 2019 25 656 66 10.1038/s41591-019-0374-x717592030833750 Search in Google Scholar

[45] Cao G, Xiao Z, Yin Z. Normalization cancer immunotherapy: blocking Siglec-15! Signal Transduct Target Ther. 2019; 4:10. doi: 10.1038/s41392-019-0045-x CaoG XiaoZ YinZ Normalization cancer immunotherapy: blocking Siglec-15! Signal Transduct Target Ther 2019 4 10 10.1038/s41392-019-0045-x 647300131016034 Open DOISearch in Google Scholar

[46] Liu Y, Li X, Zhang C, Zhang H, Huang Y. LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma. Cancer Sci. 2020; 111:3693–704. doi: 10.1111/cas.14611 LiuY LiX ZhangC ZhangH HuangY LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma Cancer Sci 2020 111 3693 704 10.1111/cas.14611 754100132780490 Open DOISearch in Google Scholar

[47] Udagawa N, Koide M, Nakamura M, Nakamichi Y, Yamashita T, Uehara S, et al. Osteoclast differentiation by RANKL and OPG signaling pathways. J Bone Miner Metab. 2021; 39:19–26. UdagawaN KoideM NakamuraM NakamichiY YamashitaT UeharaS Osteoclast differentiation by RANKL and OPG signaling pathways J Bone Miner Metab 2021 39 19 26 10.1007/s00774-020-01162-633079279 Search in Google Scholar

[48] Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, et al. Protein sialylation regulates a gene expression signature that promotes breast cancer cell pathogenicity. ACS Chem Biol. 2016; 11:2131–9. KohnzRA RobertsLS DeTomasoD BideyanL YanP BandyopadhyayS Protein sialylation regulates a gene expression signature that promotes breast cancer cell pathogenicity ACS Chem Biol 2016 11 2131 9 10.1021/acschembio.6b00433499406027380425 Search in Google Scholar

[49] Teoh ST, Ogrodzinski MP, Ross C, Hunter KW, Lunt SY. Sialic acid metabolism: a key player in breast cancer metastasis revealed by metabolomics. Front Oncol. 2018; 8:174. doi: 10.3389/fonc.2018.00174 TeohST OgrodzinskiMP RossC HunterKW LuntSY Sialic acid metabolism: a key player in breast cancer metastasis revealed by metabolomics Front Oncol 2018 8 174 10.3389/fonc.2018.00174 598544929892572 Open DOISearch in Google Scholar

[50] van den Bijgaart RJE, Kroesen M, Wassink M, Brok IC, Kers-Rebel ED, Boon L, et al. Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2. J Biol Chem. 2019; 294:4437–49. van den BijgaartRJE KroesenM WassinkM BrokIC Kers-RebelED BoonL Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2 J Biol Chem 2019 294 4437 49 10.1074/jbc.RA118.002763643306130670592 Search in Google Scholar

[51] Büll C, Heise T, Beurskens DMH, Riemersma M, Ashikov A, Rutjes FPJT, et al. Sialic acid glycoengineering using an unnatural sialic acid for the detection of sialoglycan biosynthesis defects and on-cell synthesis of Siglec ligands. ACS Chem Biol. 2015; 10:2353–63. BüllC HeiseT BeurskensDMH RiemersmaM AshikovA RutjesFPJT Sialic acid glycoengineering using an unnatural sialic acid for the detection of sialoglycan biosynthesis defects and on-cell synthesis of Siglec ligands ACS Chem Biol 2015 10 2353 63 10.1021/acschembio.5b0050126258433 Search in Google Scholar

[52] Büll C, Boltje TJ, Balneger N, Weischer SM, Wassink M, van Gemst JJ, et al. Sialic acid blockade suppresses tumor growth by enhancing T-cell-mediated tumor immunity. Cancer Res. 2018; 78:3574–88. BüllC BoltjeTJ BalnegerN WeischerSM WassinkM van GemstJJ Sialic acid blockade suppresses tumor growth by enhancing T-cell-mediated tumor immunity Cancer Res 2018 78 3574 88 10.1158/0008-5472.CAN-17-337629703719 Search in Google Scholar

[53] Nakamura K, Terai Y, Tanabe A, Ono YJ, Hayashi M, Maeda K, et al. CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways. Oncol Rep. 2017;37:3189–200. NakamuraK TeraiY TanabeA OnoYJ HayashiM MaedaK CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways Oncol Rep 2017 37 3189 200 10.3892/or.2017.5583544239928440503 Search in Google Scholar

[54] Kristiansen G, Winzer K-J, Mayordomo E, Bellach J, Schlüns K, Denkert C, et al. CD24 expression is a new prognostic marker in breast cancer. Clin Cancer Res. 2003; 9:4906–13. KristiansenG WinzerK-J MayordomoE BellachJ SchlünsK DenkertC CD24 expression is a new prognostic marker in breast cancer Clin Cancer Res 2003 9 4906 13 Search in Google Scholar

[55] Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature. 2019; 572(7769):392–6. BarkalAA BrewerRE MarkovicM KowarskyM BarkalSA ZaroBW CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy Nature 2019 572 7769 392 6 10.1038/s41586-019-1456-0669720631367043 Search in Google Scholar

[56] Abolhasani S, Shahbazloo SV, Saadati HM, Mahmoodi N, Khanbabaei N. Evaluation of serum levels of inflammation, fibrinolysis and oxidative stress markers in coronary artery disease prediction: a cross-sectional study. Arq Bras Cardiol. 2019; 113:667–74. [article in English and Portuguese] AbolhasaniS ShahbazlooSV SaadatiHM MahmoodiN KhanbabaeiN Evaluation of serum levels of inflammation, fibrinolysis and oxidative stress markers in coronary artery disease prediction: a cross-sectional study Arq Bras Cardiol 2019 113 667 74 [article in English and Portuguese] 10.5935/abc.20190159702086431482948 Search in Google Scholar

[57] Bakri RS, Afzali B, Covic A, Sriskantharan R, Bharma-Ariza P, Park WH, et al. Cardiovascular disease in renal allograft recipients is associated with elevated sialic acid or markers of inflammation. Clin Transplant. 2004; 18:201–4. BakriRS AfzaliB CovicA SriskantharanR Bharma-ArizaP ParkWH Cardiovascular disease in renal allograft recipients is associated with elevated sialic acid or markers of inflammation Clin Transplant 2004 18 201 4 10.1111/j.1399-0012.2004.00156.x15016136 Search in Google Scholar

[58] Christ ER, Cummings MH, Lumb PJ, Crook MA, Sönksen PH, Russell-Jones DL. Growth hormone (GH) replacement therapy reduces serum sialic acid concentrations in adults with GH-deficiency: a double-blind placebo-controlled study. Clin Endocrinol (Oxf). 1999; 51:173–9. ChristER CummingsMH LumbPJ CrookMA SönksenPH Russell-JonesDL Growth hormone (GH) replacement therapy reduces serum sialic acid concentrations in adults with GH-deficiency: a double-blind placebo-controlled study Clin Endocrinol (Oxf) 1999 51 173 9 10.1046/j.1365-2265.1999.00751.x10468987 Search in Google Scholar

[59] Masuda H, Wakabayashi R, Wakabayashi I. Serum sialic acid and ankle versus brachial arterial-pressure ratio in NIDDM. Scand J Clin Lab Invest. 1998; 58:433–39. MasudaH WakabayashiR WakabayashiI Serum sialic acid and ankle versus brachial arterial-pressure ratio in NIDDM Scand J Clin Lab Invest 1998 58 433 39 10.1080/003655198501864279819193 Search in Google Scholar

[60] Zhang L, Wei T-T, Li Y, Li J, Fan Y, Huang F-Q, et al. Functional metabolomics characterizes a key role for N-acetylneuraminic acid in coronary artery diseases. Circulation. 2018; 137:1374–90. ZhangL WeiT-T LiY LiJ FanY HuangF-Q Functional metabolomics characterizes a key role for N-acetylneuraminic acid in coronary artery diseases Circulation 2018 137 1374 90 10.1161/CIRCULATIONAHA.117.03113929212895 Search in Google Scholar

[61] Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003; 107:499–511. PearsonTA MensahGA AlexanderRW AndersonJL CannonRO3rd CriquiM Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association Circulation 2003 107 499 511 10.1161/01.CIR.0000052939.59093.45 Search in Google Scholar

[62] Nigam PK, Narain VS, Kumar A. Sialic acid in cardiovascular diseases. Indian J Clin Biochem. 2006; 21:54–61. NigamPK NarainVS KumarA Sialic acid in cardiovascular diseases Indian J Clin Biochem 2006 21 54 61 10.1007/BF02913067345378423105570 Search in Google Scholar

[63] Baumann H, Gauldie J. The acute phase response. Immunol Today. 1994; 15:74–80. BaumannH GauldieJ The acute phase response Immunol Today 1994 15 74 80 10.1016/0167-5699(94)90137-6 Search in Google Scholar

[64] Romero R, Lens XM, Novoa D, Arcocha V, Alonso R, Arza MD, et al. Sialic acid is a predictor of cardiovascular complications in renal transplantation recipients. Nephron. 1993; 65:489–90. RomeroR LensXM NovoaD ArcochaV AlonsoR ArzaMD Sialic acid is a predictor of cardiovascular complications in renal transplantation recipients Nephron 1993 65 489 90 10.1159/0001875458290012 Search in Google Scholar

[65] Ogasawara Y, Namai T, Yoshino F, Lee M-C-i, Ishii K. Sialic acid is an essential moiety of mucin as a hydroxyl radical scavenger. FEBS Lett. 2007; 581:2473–7. OgasawaraY NamaiT YoshinoF LeeM-C-i IshiiK Sialic acid is an essential moiety of mucin as a hydroxyl radical scavenger FEBS Lett 2007 581 2473 7 10.1016/j.febslet.2007.04.06217485090 Search in Google Scholar

[66] Tertov VV, Sobenin IA, Orekhov AN. Characterization of desialylated low-density lipoproteins which cause intracellular lipid accumulation. Int J Tissue React. 1992; 14:155–62. TertovVV SobeninIA OrekhovAN Characterization of desialylated low-density lipoproteins which cause intracellular lipid accumulation Int J Tissue React 1992 14 155 62 Search in Google Scholar

[67] Knuiman MW, Watts GF, Divitini ML. Is sialic acid an independent risk factor for cardiovascular disease? A 17-year follow-up study in Busselton, Western Australia. Ann Epidemiol. 2004; 14:627–32. KnuimanMW WattsGF DivitiniML Is sialic acid an independent risk factor for cardiovascular disease? A 17-year follow-up study in Busselton, Western Australia Ann Epidemiol 2004 14 627 32 10.1016/j.annepidem.2003.09.01715380792 Search in Google Scholar

[68] Prajna K, Kumar JA, Rai S, Shetty SK, Rai T, Shrinidhi, et al. Predictive value of serum sialic acid in type-2 diabetes mellitus and its complication (nephropathy). J Clin Diagn Res. 2013; 7:2435–7. doi: 10.7860/jcdr/2013/6210.3567 PrajnaK KumarJA RaiS ShettySK RaiT Shrinidhi Predictive value of serum sialic acid in type-2 diabetes mellitus and its complication (nephropathy) J Clin Diagn Res 2013 7 2435 7 10.7860/jcdr/2013/6210.3567 387988624392365 Open DOISearch in Google Scholar

[69] Nayak SB, Bhaktha G. Relationship between sialic acid and metabolic variables in Indian type 2 diabetic patients. Lipids Health Dis. 2005; 4:15. doi: 10.1186/1476-511x-4-15 NayakSB BhakthaG Relationship between sialic acid and metabolic variables in Indian type 2 diabetic patients Lipids Health Dis 2005 4 15 10.1186/1476-511x-4-15 Open DOISearch in Google Scholar

[70] Varma V, Varma M, Varma A, Kumar R, Bharosay A, Vyas S. Serum total sialic acid and highly sensitive C-reactive protein: prognostic markers for the diabetic nephropathy. J Lab Physicians. 2016; 8:25–9. doi: 10.4103/0974-2727.176230 VarmaV VarmaM VarmaA KumarR BharosayA VyasS Serum total sialic acid and highly sensitive C-reactive protein: prognostic markers for the diabetic nephropathy J Lab Physicians 2016 8 25 9 10.4103/0974-2727.176230 478576127013809 Open DOISearch in Google Scholar

[71] Shivananda Nayak B, Duncan H, Lalloo S, Maraj K, Matmungal V, Matthews F, et al. Correlation of microalbumin and sialic acid with anthropometric variables in type 2 diabetic patients with and without nephropathy. Vasc Health Risk Manag. 2008; 4:243–7. Shivananda NayakB DuncanH LallooS MarajK MatmungalV MatthewsF Correlation of microalbumin and sialic acid with anthropometric variables in type 2 diabetic patients with and without nephropathy Vasc Health Risk Manag 2008 4 243 7 10.2147/VHRM.2.94.134.1572 Search in Google Scholar

[72] Animaw W, Seyoum Y. Increasing prevalence of diabetes mellitus in a developing country and its related factors. PLoS One. 2017; 12:e0187670. doi: 10.1371/journal.pone.0187670 AnimawW SeyoumY Increasing prevalence of diabetes mellitus in a developing country and its related factors PLoS One 2017 12 e0187670 10.1371/journal.pone.0187670 567540229112962 Open DOISearch in Google Scholar

[73] Rogers ME, Williams DT, Niththyananthan R, Rampling MW, Heslop KE, Johnston DG. Decrease in erythrocyte glycophorin sialic acid content is associated with increased erythrocyte aggregation in human diabetes. Clin Sci (Lond). 1992; 82:309–13. RogersME WilliamsDT NiththyananthanR RamplingMW HeslopKE JohnstonDG Decrease in erythrocyte glycophorin sialic acid content is associated with increased erythrocyte aggregation in human diabetes Clin Sci (Lond) 1992 82 309 13 10.1042/cs08203091312416 Search in Google Scholar

[74] Shahvali S, Shahesmaeili A, Sanjari M, Karami-Mohajeri S. The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia. Diabetol Int. 2020; 11:19–26. doi: 10.1007/s13340-019-00395-9 ShahvaliS ShahesmaeiliA SanjariM Karami-MohajeriS The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia Diabetol Int 2020 11 19 26 10.1007/s13340-019-00395-9 Open DOISearch in Google Scholar

[75] Freeze HH, Eklund EA, Ng BG, Patterson MC. Neurology of inherited glycosylation disorders. Lancet Neurol. 2012; 11:453–66. FreezeHH EklundEA NgBG PattersonMC Neurology of inherited glycosylation disorders Lancet Neurol 2012 11 453 66 10.1016/S1474-4422(12)70040-6 Search in Google Scholar

[76] Siddiqui SS, Matar R, Merheb M, Hodeify R, Vazhappilly CG, Marton J, et al. Siglecs in brain function and neurological disorders. Cells. 2019; 8:1125. doi: 10.3390/cells8101125 SiddiquiSS MatarR MerhebM HodeifyR VazhappillyCG MartonJ Siglecs in brain function and neurological disorders Cells 2019 8 1125 10.3390/cells8101125 Open DOISearch in Google Scholar

[77] Schnaar RL, Gerardy-Schahn R, Hildebrandt H. Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev. 2014; 94:461–518. SchnaarRL Gerardy-SchahnR HildebrandtH Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration Physiol Rev 2014 94 461 518 10.1152/physrev.00033.2013 Search in Google Scholar

[78] Wielgat P, Walesiuk A, Braszko JJ. Effects of chronic stress and corticosterone on sialidase activity in the rat hippocampus. Behav Brain Res. 2011; 222:363–7. WielgatP WalesiukA BraszkoJJ Effects of chronic stress and corticosterone on sialidase activity in the rat hippocampus Behav Brain Res 2011 222 363 7 10.1016/j.bbr.2011.03.070 Search in Google Scholar

[79] Boyzo A, Ayala J, Gutiérrez R, Hernández-RJ. Neuraminidase activity in different regions of the seizing epileptic and non-epileptic brain. Brain Res. 2003; 964:211–7. BoyzoA AyalaJ GutiérrezR HernándezRJ Neuraminidase activity in different regions of the seizing epileptic and non-epileptic brain Brain Res 2003 964 211 7 10.1016/S0006-8993(02)03985-9 Search in Google Scholar

[80] Minami A, Meguro Y, Ishibashi S, Ishii A, Shiratori M, Sai S, et al. Rapid regulation of sialidase activity in response to neural activity and sialic acid removal during memory processing in rat hippocampus. J Biol Chem. 2017; 292:5645–54. MinamiA MeguroY IshibashiS IshiiA ShiratoriM SaiS Rapid regulation of sialidase activity in response to neural activity and sialic acid removal during memory processing in rat hippocampus J Biol Chem 2017 292 5645 54 10.1074/jbc.M116.764357539256028213516 Search in Google Scholar

[81] Minami A, Ishii A, Shimba S, Kano T, Fujioka E, Sai S, et al. Down-regulation of glutamate release from hippocampal neurons by sialidase. J Biochem. 2018; 163:273–80. MinamiA IshiiA ShimbaS KanoT FujiokaE SaiS Down-regulation of glutamate release from hippocampal neurons by sialidase J Biochem 2018 163 273 80 10.1093/jb/mvy00329319803 Search in Google Scholar

[82] Annunziata I, Patterson A, Helton D, Hu H, Moshiach S, Gomero E, et al. Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis. Nat Commun. 2013; 4:2734. doi: 10.1038/ncomms3734 AnnunziataI PattersonA HeltonD HuH MoshiachS GomeroE Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis Nat Commun 2013 4 2734 10.1038/ncomms3734 401546324225533 Open DOISearch in Google Scholar

[83] Schneider JS, Seyfried TN, Choi H-S, Kidd SK. Intraventricular sialidase administration enhances GM1 ganglioside expression and is partially neuroprotective in a mouse model of Parkinson's disease. PLoS One. 2015; 10:e0143351. doi: 10.1371/journal.pone.0143351 SchneiderJS SeyfriedTN ChoiH-S KiddSK Intraventricular sialidase administration enhances GM1 ganglioside expression and is partially neuroprotective in a mouse model of Parkinson's disease PLoS One 2015 10 e0143351 10.1371/journal.pone.0143351 466804926629687 Open DOISearch in Google Scholar

[84] De Palma M, Biziato D, Petrova TV. Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 2017; 17:457–74. De PalmaM BiziatoD PetrovaTV Microenvironmental regulation of tumour angiogenesis Nat Rev Cancer 2017 17 457 74 10.1038/nrc.2017.5128706266 Search in Google Scholar

[85] Chiodelli P, Urbinati C, Paiardi G, Monti E, Rusnati M. Sialic acid as a target for the development of novel antiangiogenic strategies. Future Med Chem. 2018; 10:2835–54. ChiodelliP UrbinatiC PaiardiG MontiE RusnatiM Sialic acid as a target for the development of novel antiangiogenic strategies Future Med Chem 2018 10 2835 54 10.4155/fmc-2018-029830539670 Search in Google Scholar

[86] Szabo R, Skropeta D. Advancement of sialyltransferase inhibitors: therapeutic challenges and opportunities. Med Res Rev. 2017; 37:219–70. SzaboR SkropetaD Advancement of sialyltransferase inhibitors: therapeutic challenges and opportunities Med Res Rev 2017 37 219 70 10.1002/med.2140727678392 Search in Google Scholar

[87] Elgohary MM, Helmy MW, Abdelfattah E-ZA, Ragab DM, Mortada SM, Fang J-Y, Elzoghby AO. Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy. J Control Release. 2018; 285:230–43. ElgoharyMM HelmyMW AbdelfattahE-ZA RagabDM MortadaSM FangJ-Y ElzoghbyAO Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy J Control Release 2018 285 230 43 10.1016/j.jconrel.2018.07.01430009892 Search in Google Scholar

[88] Wang X, Tang H, Wang C, Zhang J, Wu W, Jiang X. Phenylboronic acid-mediated tumor targeting of chitosan nanoparticles. Theranostics. 2016; 6:1378–92. WangX TangH WangC ZhangJ WuW JiangX Phenylboronic acid-mediated tumor targeting of chitosan nanoparticles Theranostics 2016 6 1378 92 10.7150/thno.15156492450627375786 Search in Google Scholar

[89] Wang J, Wu W, Zhang Y, Wang X, Qian H, Liu B, Jiang X. The combined effects of size and surface chemistry on the accumulation of boronic acid-rich protein nanoparticles in tumors. Biomaterials. 2014; 35:866–78. WangJ WuW ZhangY WangX QianH LiuB JiangX The combined effects of size and surface chemistry on the accumulation of boronic acid-rich protein nanoparticles in tumors Biomaterials 2014 35 866 78 10.1016/j.biomaterials.2013.10.02824157313 Search in Google Scholar

[90] Tian H, Liu Q, Qin S, Zong C, Zhang Y, Yao S, et al. Synthesis and cardiovascular protective effects of quercetin 7-O-sialic acid. J Cell Mol Med. 2017; 21:107–20. TianH LiuQ QinS ZongC ZhangY YaoS Synthesis and cardiovascular protective effects of quercetin 7-O-sialic acid J Cell Mol Med 2017 21 107 20 10.1111/jcmm.12943519294327511707 Search in Google Scholar

[91] Xu X-L, Li W-S, Wang X-J, Du Y-L, Kang X-Q, Hu J-B, et al. Endogenous sialic acid-engineered micelles: a multifunctional platform for on-demand methotrexate delivery and bone repair of rheumatoid arthritis. Nanoscale. 2018; 10:2923–35. XuX-L LiW-S WangX-J DuY-L KangX-Q HuJ-B Endogenous sialic acid-engineered micelles: a multifunctional platform for on-demand methotrexate delivery and bone repair of rheumatoid arthritis Nanoscale 2018 10 2923 35 10.1039/C7NR08430G Search in Google Scholar

[92] Zhu M-L, Xu X-L, Wang X-J, Zhang N-N, Lu K-J, Qi J, et al. Sialic-acid-anchored micelles: a hierarchical targeting device for enhanced tumor tissue accumulation and cellular internalization. Mol Pharm. 2018; 15:4235–46. ZhuM-L XuX-L WangX-J ZhangN-N LuK-J QiJ Sialic-acid-anchored micelles: a hierarchical targeting device for enhanced tumor tissue accumulation and cellular internalization Mol Pharm 2018 15 4235 46 10.1021/acs.molpharmaceut.8b0064930110551 Search in Google Scholar

[93] Lin C-H, Yeh Y-C, Yang KD. Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers. J Formos Med Assoc. 2021; 120:5–24. LinC-H YehY-C YangKD Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers J Formos Med Assoc 2021 120 5 24 10.1016/j.jfma.2019.10.01931882261 Search in Google Scholar

[94] Khairnar A, Sunsunwal S, Babu P, Ramya TNC. Novel serine/threonine-O-glycosylation with N-acetylneuraminic acid and 3-deoxy-D-manno-octulosonic acid by bacterial flagellin glycosyltransferases. Glycobiology. 2021; 31:288–306. KhairnarA SunsunwalS BabuP RamyaTNC Novel serine/threonine-O-glycosylation with N-acetylneuraminic acid and 3-deoxy-D-manno-octulosonic acid by bacterial flagellin glycosyltransferases Glycobiology 2021 31 288 306 10.1093/glycob/cwaa084 Search in Google Scholar

[95] King AMQ, Adams MJ, Lefkowitz E, Carstens EB, editors. Virus taxonomy: classification and nomenclature of viruses. Ninth Report of the International Committee on Taxonomy of Viruses. San Diego: Elsevier Academic Press; 2011, p. 1327. KingAMQ AdamsMJ LefkowitzE CarstensEB editors. Virus taxonomy: classification and nomenclature of viruses. Ninth Report of the International Committee on Taxonomy of Viruses San Diego Elsevier Academic Press 2011 1327 Search in Google Scholar

[96] Herrler G, Klenk HD. Structure and function of the HEF glycoprotein of influenza C virus. Adv Virus Res. 1991; 40:213–34. HerrlerG KlenkHD Structure and function of the HEF glycoprotein of influenza C virus Adv Virus Res 1991 40 213 34 10.1016/S0065-3527(08)60280-8 Search in Google Scholar

[97] Rosenberg A, editor. Biology of the sialic acids. New York: Springer Science; 1995. RosenbergA editor. Biology of the sialic acids New York Springer Science 1995 10.1007/978-1-4757-9504-2 Search in Google Scholar

[98] Hellebø A, Vilas U, Falk K, Vlasak R. Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids. J Virol. 2004; 78:3055–62. HellebøA VilasU FalkK VlasakR Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids J Virol 2004 78 3055 62 10.1128/JVI.78.6.3055-3062.200435376514990724 Search in Google Scholar

[99] Falk K, Aspehaug V, Vlasak R, Endresen C. Identification and characterization of viral structural proteins of infectious salmon anemia virus. J Virol. 2004; 78:3063–71. FalkK AspehaugV VlasakR EndresenC Identification and characterization of viral structural proteins of infectious salmon anemia virus J Virol 2004 78 3063 71 10.1128/JVI.78.6.3063-3071.200435376714990725 Search in Google Scholar

[100] Schultze B, Krempl C, Ballesteros ML, Shaw L, Schauer R, Enjuanes L, Herrler G. Transmissible gastroenteritis coronavirus, but not the related porcine respiratory coronavirus, has a sialic acid (N-glycolylneuraminic acid) binding activity. J Virol. 1996; 70:5634–7. SchultzeB KremplC BallesterosML ShawL SchauerR EnjuanesL HerrlerG Transmissible gastroenteritis coronavirus, but not the related porcine respiratory coronavirus, has a sialic acid (N-glycolylneuraminic acid) binding activity J Virol 1996 70 5634 7 10.1128/jvi.70.8.5634-5637.19961905248764078 Search in Google Scholar

[101] Noda M, Koide F, Asagi M, Inaba Y. Physicochemical properties of transmissible gastroenteritis virus hemagglutinin. Arch Virol. 1988; 99:163–72. NodaM KoideF AsagiM InabaY Physicochemical properties of transmissible gastroenteritis virus hemagglutinin Arch Virol 1988 99 163 72 10.1007/BF0131106770869462835945 Search in Google Scholar

[102] Schultze B, Herrler G. Bovine coronavirus uses N-acetyl-9-O-acetylneuraminic acid as a receptor determinant to initiate the infection of cultured cells. J Gen Virol. 1992; 73(Pt 4):901–6. SchultzeB HerrlerG Bovine coronavirus uses N-acetyl-9-O-acetylneuraminic acid as a receptor determinant to initiate the infection of cultured cells J Gen Virol 1992 73 Pt 4 901 6 10.1099/0022-1317-73-4-9011321878 Search in Google Scholar

[103] Li B, Wang L, Ge H, Zhang X, Ren P, Guo Y, et al. Identification of potential binding sites of sialic acids on the RBD domain of SARS-CoV-2 spike protein. Front Chem. 2021; 9:659764. doi: 10.3389/fchem.2021.659764 LiB WangL GeH ZhangX RenP GuoY Identification of potential binding sites of sialic acids on the RBD domain of SARS-CoV-2 spike protein Front Chem 2021 9 659764 10.3389/fchem.2021.659764 834143434368076 Open DOISearch in Google Scholar

[104] Winter C, Schwegmann-Weßels C, Cavanagh D, Neumann U, Herrler G. Sialic acid is a receptor determinant for infection of cells by avian Infectious bronchitis virus. J Gen Virol. 2006; 87(Pt 5): 1209–16. WinterC Schwegmann-WeßelsC CavanaghD NeumannU HerrlerG Sialic acid is a receptor determinant for infection of cells by avian Infectious bronchitis virus J Gen Virol 2006 87 Pt 5 1209 16 10.1099/vir.0.81651-016603523 Search in Google Scholar

[105] Sherman MB, Williams AN, Smith HQ, Nelson C, Wilen CB, Fremont DH, et al. Bile salts alter the mouse norovirus capsid conformation: possible implications for cell attachment and immune evasion. J Virol. 2019; 93:e00970–19. doi: 10.1128/jvi.00970-19 ShermanMB WilliamsAN SmithHQ NelsonC WilenCB FremontDH Bile salts alter the mouse norovirus capsid conformation: possible implications for cell attachment and immune evasion J Virol 2019 93 e00970 19 10.1128/jvi.00970-19 674423031341042 Open DOISearch in Google Scholar

[106] Taube S, Perry JW, Yetming K, Patel SP, Auble H, Shu L, et al. Ganglioside-linked terminal sialic acid moieties on murine macrophages function as attachment receptors for murine noroviruses. J Virol. 2009; 83:4092–101. TaubeS PerryJW YetmingK PatelSP AubleH ShuL Ganglioside-linked terminal sialic acid moieties on murine macrophages function as attachment receptors for murine noroviruses J Virol 2009 83 4092 101 10.1128/JVI.02245-08266849719244326 Search in Google Scholar

[107] Alexander DA, Dimock K. Sialic acid functions in enterovirus 70 binding and infection. J Virol. 2002; 76:11265–72. AlexanderDA DimockK Sialic acid functions in enterovirus 70 binding and infection J Virol 2002 76 11265 72 10.1128/JVI.76.22.11265-11272.200213675812388686 Search in Google Scholar

[108] Nokhbeh MR, Hazra S, Alexander DA, Khan A, McAllister M, Suuronen EJ, et al. Enterovirus 70 binds to different glycoconjugates containing α2,3-linked sialic acid on different cell lines. J Virol. 2005; 79:7087–94. NokhbehMR HazraS AlexanderDA KhanA McAllisterM SuuronenEJ Enterovirus 70 binds to different glycoconjugates containing α2,3-linked sialic acid on different cell lines J Virol 2005 79 7087 94 10.1128/JVI.79.11.7087-7094.2005111209915890948 Search in Google Scholar

[109] Dukhinova M, Veremeyko T, Yung AWY, Kuznetsova IS, Lau TYB, Kopeikina E, et al. Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease. Neurobiol Aging. 2019; 77:128–43. DukhinovaM VeremeykoT YungAWY KuznetsovaIS LauTYB KopeikinaE Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease Neurobiol Aging 2019 77 128 43 10.1016/j.neurobiolaging.2019.01.02030797170 Search in Google Scholar

[110] Ding J, Sui D, Liu M, Su Y, Wang Y, Liu M, et al. Sialic acid conjugate-modified liposomes enable tumor homing of epirubicin via neutrophil/monocyte infiltration for tumor therapy. Acta Biomater. 2021; 134:702–15. DingJ SuiD LiuM SuY WangY LiuM Sialic acid conjugate-modified liposomes enable tumor homing of epirubicin via neutrophil/monocyte infiltration for tumor therapy Acta Biomater 2021 134 702 15 10.1016/j.actbio.2021.07.06334339869 Search in Google Scholar

[111] Sun J, Tian Q, Liu M, Su Y, Liu X, Deng Y, et al. Evaluation of the antitumor effect and immune response of micelles modified with a polysialic acid-d-α-tocopheryl polyethylene glycol 1000 succinate conjugate. AAPS PharmSciTech. 2021; 22:223. doi: 10.1208/s12249-021-02047-1 SunJ TianQ LiuM SuY LiuX DengY Evaluation of the antitumor effect and immune response of micelles modified with a polysialic acid-d-α-tocopheryl polyethylene glycol 1000 succinate conjugate AAPS PharmSciTech 2021 22 223 10.1208/s12249-021-02047-1 34409520 Open DOISearch in Google Scholar

[112] Xu Q, Shan Y, Wang N, Liu Y, Zhang M, Ma M. Sialic acid involves in the interaction between ovomucin and hemagglutinin and influences the antiviral activity of ovomucin. Int J Biol Macromol. 2018; 119:533–9. XuQ ShanY WangN LiuY ZhangM MaM Sialic acid involves in the interaction between ovomucin and hemagglutinin and influences the antiviral activity of ovomucin Int J Biol Macromol 2018 119 533 9 10.1016/j.ijbiomac.2018.07.186712466030071221 Search in Google Scholar

[113] Wang X-J, Shu G-F, Xu X-L, Peng C-H, Lu C-Y, Cheng X-Y, et al. Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles. Biomaterials. 2019; 217:119326. doi: 10.1016/j.biomaterials.2019.119326 WangX-J ShuG-F XuX-L PengC-H LuC-Y ChengX-Y Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles Biomaterials 2019 217 119326 10.1016/j.biomaterials.2019.119326 31288173 Open DOISearch in Google Scholar

[114] Morozzi C, Sedláková J, Serpi M, Avigliano M, Carbajo R, Sandoval L, et al. Targeting GNE myopathy: a dual prodrug approach for the delivery of N-acetylmannosamine 6-phosphate. J Med Chem. 2019; 62:8178–93. MorozziC SedlákováJ SerpiM AviglianoM CarbajoR SandovalL Targeting GNE myopathy: a dual prodrug approach for the delivery of N-acetylmannosamine 6-phosphate J Med Chem 2019 62 8178 93 10.1021/acs.jmedchem.9b0083331386361 Search in Google Scholar

[115] Lai X, Wang S, Hu M, Sun Y, Chen M, Liu M, et al. Dual targeting single arrow: neutrophil-targeted sialic acid-modified nanoplatform for treating comorbid tumors and rheumatoid arthritis. Int J Pharm. 2021; 607:121022. doi: 10.1016/j.ijpharm.2021.121022 LaiX WangS HuM SunY ChenM LiuM Dual targeting single arrow: neutrophil-targeted sialic acid-modified nanoplatform for treating comorbid tumors and rheumatoid arthritis Int J Pharm 2021 607 121022 10.1016/j.ijpharm.2021.121022 Open DOISearch in Google Scholar

[116] Svennerholm L. Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. Biochim Biophys Acta. 1957; 24:604–11. SvennerholmL Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method Biochim Biophys Acta 1957 24 604 11 10.1016/0006-3002(57)90254-8 Search in Google Scholar

[117] Warren L. The thiobarbituric acid assay of sialic acids. J Biol Chem. 1959; 234:1971–5. WarrenL The thiobarbituric acid assay of sialic acids J Biol Chem 1959 234 1971 5 10.1016/S0021-9258(18)69851-5 Search in Google Scholar

[118] Roboz J, Suttajit M, Bekesi JG. Elimination of 2-deoxyribose interference in the thiobarbituric acid determination of N-acetylneuraminic acid in tumor cells by pH-dependent extraction with cyclohexanone. Anal Biochem. 1981; 110:380–8. RobozJ SuttajitM BekesiJG Elimination of 2-deoxyribose interference in the thiobarbituric acid determination of N-acetylneuraminic acid in tumor cells by pH-dependent extraction with cyclohexanone Anal Biochem 1981 110 380 8 10.1016/0003-2697(81)90207-4 Search in Google Scholar

[119] Durand G, Feger J, Coignoux M, Agneray J, Pays M. Rapid estimation of small amounts of formaldehyde liberated during periodate oxidation of a sialoglycoprotein. Anal Biochem. 1974; 61:232–6. DurandG FegerJ CoignouxM AgnerayJ PaysM Rapid estimation of small amounts of formaldehyde liberated during periodate oxidation of a sialoglycoprotein Anal Biochem 1974 61 232 6 10.1016/0003-2697(74)90349-2 Search in Google Scholar

[120] Massamiri Y, Durand G, Richard A, Féger J, Agneray J. Determination of erythrocyte surface sialic acid residues by a new colorimetric method. Anal Biochem. 1979; 97:346–51. MassamiriY DurandG RichardA FégerJ AgnerayJ Determination of erythrocyte surface sialic acid residues by a new colorimetric method Anal Biochem 1979 97 346 51 10.1016/0003-2697(79)90084-8 Search in Google Scholar

[121] Yao K, Ubuka T. Determination of sialic acids by acidic ninhydrin reaction. Acta Med Okayama. 1987; 41:237–41. YaoK UbukaT Determination of sialic acids by acidic ninhydrin reaction Acta Med Okayama 1987 41 237 41 Search in Google Scholar

[122] Yao K, Ubuka T, Masuoka N, Kinuta M, Ikeda T. Direct determination of bound sialic acids in sialoglycoproteins by acidic ninhydrin reaction. Anal Biochem. 1989; 179:332–5. YaoK UbukaT MasuokaN KinutaM IkedaT Direct determination of bound sialic acids in sialoglycoproteins by acidic ninhydrin reaction Anal Biochem 1989 179 332 5 10.1016/0003-2697(89)90138-3 Search in Google Scholar

[123] Mudd AT, Salcedo J, Alexander LS, Johnson SK, Getty CM, Chichlowski M, et al. Porcine milk oligosaccharides and sialic acid concentrations vary throughout lactation. Front Nutr. 2016; 3:39. doi: 10.3389/fnut.2016.00039 MuddAT SalcedoJ AlexanderLS JohnsonSK GettyCM ChichlowskiM Porcine milk oligosaccharides and sialic acid concentrations vary throughout lactation Front Nutr 2016 3 39 10.3389/fnut.2016.00039 Open DOISearch in Google Scholar

[124] Sugahara K, Sugimoto K, Nomura O, Usui T. Enzymatic assay of serum sialic acid. Clin Chim Acta. 1980; 108:493–8. SugaharaK SugimotoK NomuraO UsuiT Enzymatic assay of serum sialic acid Clin Chim Acta 1980 108 493 8 10.1016/0009-8981(80)90360-5 Search in Google Scholar

[125] Taniuchi K, Chifu K, Hayashi N, Nakamachi Y, Yamaguchi N, Miyamoto Y, et al. A new enzymatic method for the determination of sialic acid in serum and its application for a marker of acute phase reactants. Kobe J Med Sci. 1981; 27:91–102. TaniuchiK ChifuK HayashiN NakamachiY YamaguchiN MiyamotoY A new enzymatic method for the determination of sialic acid in serum and its application for a marker of acute phase reactants Kobe J Med Sci 1981 27 91 102 Search in Google Scholar

[126] Li W, Liu Y, Zheng X, Gao J, Wang L, Li Y. Investigation of the potential use of sialic acid as a biomarker for rheumatoid arthritis. Ann Clin Lab Sci. 2019; 49:224–31. LiW LiuY ZhengX GaoJ WangL LiY Investigation of the potential use of sialic acid as a biomarker for rheumatoid arthritis Ann Clin Lab Sci 2019 49 224 31 Search in Google Scholar

[127] Hernández-Arteaga AC, de Jesús Zermeño-Nava J, Martínez-Martínez MU, Hernández-Cedillo A, Ojeda-Galván HJ, José-Yacamán M, Navarro-Contreras HR. Determination of salivary sialic acid through nanotechnology: a useful biomarker for the screening of breast cancer. Arch Med Res. 2019; 50:105–10. Hernández-ArteagaAC de Jesús Zermeño-NavaJ Martínez-MartínezMU Hernández-CedilloA Ojeda-GalvánHJ José-YacamánM Navarro-ContrerasHR Determination of salivary sialic acid through nanotechnology: a useful biomarker for the screening of breast cancer Arch Med Res 2019 50 105 10 10.1016/j.arcmed.2019.05.01331495386 Search in Google Scholar

[128] Zermeño-Nava JJ, Martínez-Martínez MU, Rámirez-de-Ávila AL, Hernández-Arteaga AC, García-Valdivieso MG, Hernández-Cedillo A, et al. Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases. J Ovarian Res. 2018; 11:61. doi: 10.1186/s13048-018-0433-9 Zermeño-NavaJJ Martínez-MartínezMU Rámirez-de-ÁvilaAL Hernández-ArteagaAC García-ValdiviesoMG Hernández-CedilloA Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases J Ovarian Res 2018 11 61 10.1186/s13048-018-0433-9 605837130041680 Open DOISearch in Google Scholar

[129] Sun Y, Sun C, Zhang E. Expression of serum sialic acid, early antigen-IgA, and viral capsid antigen-IgA in nasopharynx cancer patients: the diagnostic implication of combined assays. Med Sci Monit. 2015; 21:4068–73. SunY SunC ZhangE Expression of serum sialic acid, early antigen-IgA, and viral capsid antigen-IgA in nasopharynx cancer patients: the diagnostic implication of combined assays Med Sci Monit 2015 21 4068 73 10.12659/MSM.894951469962026709095 Search in Google Scholar

[130] Haroun RA, Osman WH, Eessa AM. Evaluation of serum total sialic acid in moderate COVID-19 patients with and without gastrointestinal tract manifestations. Tissue Cell. 2022; 74:101679. doi: 10.1016/j.tice.2021.101679 HarounRA OsmanWH EessaAM Evaluation of serum total sialic acid in moderate COVID-19 patients with and without gastrointestinal tract manifestations Tissue Cell 2022 74 101679 10.1016/j.tice.2021.101679 859839634801789 Open DOISearch in Google Scholar

[131] Rasool M, Khan SR, Malik A, Khan KM, Zahid S, Manan A, et al. Comparative studies of salivary and blood sialic acid, lipid peroxidation and antioxidative status in oral squamous cell carcinoma (OSCC). Pak J Med Sci. 2014; 30:466–71. RasoolM KhanSR MalikA KhanKM ZahidS MananA Comparative studies of salivary and blood sialic acid, lipid peroxidation and antioxidative status in oral squamous cell carcinoma (OSCC) Pak J Med Sci 2014 30 466 71 10.12669/pjms.303.4985404848724948960 Search in Google Scholar