<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_FON-2019-0027_s_006_w2aab3b7b1b1b6b1aab1c17b1Aa"><h3>Objective</h3><p>To evaluate the effectiveness of integrated nursing interventions for fatigue in patients with advanced cancer.</p></sec><sec id="j_FON-2019-0027_s_007_w2aab3b7b1b1b6b1aab1c17b2Aa"><h3>Methods</h3><p>Medline, Pubmed, Embase, CINAHL, Web of Science, and the Cochrane Library were searched systematically till June 2017. A systematic review was conducted to collect randomized controlled trials (RCTs) reporting on the effect of nurse-driven interventions to improve fatigue in patients with advanced cancer. Quality assessment was conducted using the Cochrane Collaboration’s risk of bias tool.</p></sec><sec id="j_FON-2019-0027_s_008_w2aab3b7b1b1b6b1aab1c17b3Aa"><h3>Results</h3><p>Six RCTs involving 736 adult participants were included. The fatigue intensity was improved significantly by nursing interventions. The analyzed results revealed significant improvements in the intervention group: less than 3 months (standard mean difference [SMD] = −0.33, 95% confidence interval [CI] [−0.48, −0.19], <italic>P</italic> &lt; 0.01) and more than or equal to 3 months (SMD = −0.40, 95% CI [−0.57, −0.24], <italic>P</italic> &lt; 0.01). Four studies with a moderate risk of bias were judged, and the remaining studies were at high risk of bias.</p></sec><sec id="j_FON-2019-0027_s_009_w2aab3b7b1b1b6b1aab1c17b4Aa"><h3>Conclusions</h3><p>The results indicate that integrated nursing interventions may relieve fatigue in patients with advanced cancer. However, due to the high risk of bias in most of the included studies and the diversity of interventions, the results and implementation process should be carefully monitored.</p></sec></abstract>

ObjectiveTo evaluate the effectiveness of integrated nursing interventions for fatigue in patients with advanced cancer.MethodsMedline, Pubmed, Embase, CINAHL, Web of Science, and the Cochrane Library were searched systematically till June 2017. A systematic review was conducted to collect randomized controlled trials (RCTs) reporting on the effect of nurse-driven interventions to improve fatigue in patients with advanced cancer. Quality assessment was conducted using the Cochrane Collaboration’s risk of bias tool.ResultsSix RCTs involving 736 adult participants were included. The fatigue intensity was improved significantly by nursing interventions. The analyzed results revealed significant improvements in the intervention group: less than 3 months (standard mean difference [SMD] = −0.33, 95% confidence interval [CI] [−0.48, −0.19], P < 0.01) and more than or equal to 3 months (SMD = −0.40, 95% CI [−0.57, −0.24], P < 0.01). Four studies with a moderate risk of bias were judged, and the remaining studies were at high risk of bias.ConclusionsThe results indicate that integrated nursing interventions may relieve fatigue in patients with advanced cancer. However, due to the high risk of bias in most of the included studies and the diversity of interventions, the results and implementation process should be carefully monitored.

Effectiveness of integrated nursing interventions for fatigue in patients with advanced cancer: a systematic review of randomized controlled trials

Frontiers of Nursing

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

ObjectiveTo evaluate the effectiveness of integrated nursing interventions for fatigue in patients with advanced cancer.MethodsMedline, Pubmed, Embase, CINAHL,...

Effectiveness of integrated nursing interventions for fatigue in patients with advanced cancer: a systematic review of randomized controlled trials

Article Category: Original article

Published Online: Nov 07, 2019

Page range: 203 - 210

Received: Jul 17, 2018

Accepted: Dec 23, 2018

DOI: https://doi.org/10.2478/FON-2019-0027

Keywords
fatigue, neoplasms, nurses, palliative care, advanced, evidence-based nursing, systematic review, hospice and palliative care nursing

© 2019 Xiao-Lin Zuo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Effectiveness of integrated nursing interventions for fatigue in patients with advanced cancer: a systematic review of randomized controlled trials

Article Category: Original article

Published Online: Nov 07, 2019

Page range: 203 - 210

Received: Jul 17, 2018

Accepted: Dec 23, 2018

DOI: https://doi.org/10.2478/FON-2019-0027

Keywordsfatigue, neoplasms, nurses, palliative care, advanced, evidence-based nursing, systematic review, hospice and palliative care nursing

© 2019 Xiao-Lin Zuo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
fatigue, neoplasms, nurses, palliative care, advanced, evidence-based nursing, systematic review, hospice and palliative care nursing