<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_FON-2019-0014_s_008_w2aab3b7b1b1b6b1aab1c18b1Aa"><h3>Objective</h3><p>Cytokine release syndrome (CRS) and tumor lysis syndrome (TLS) that occur after chimeric antigen receptor T (CAR-T) cells are reinfused, which severely affect the survival and prognosis of patients. Although several articles have reported on the care of CAR-T cell immunotherapy, the quality of the study and the effectiveness of holistic nursing interventions have not been systematically reviewed. The purpose of this study was to systematically evaluate the existing holistic nursing interventions of CAR-T cell immunotherapy.</p></sec><sec id="j_FON-2019-0014_s_009_w2aab3b7b1b1b6b1aab1c18b2Aa"><h3>Methods</h3><p>A literature search for keywords was performed in PubMed, EMBASE, the Cochrane Library, CNKI, CBM, and Wanfang Data from its inception until January 2018. Studies were deemed eligible if they comprised patients with tumor receiving CAR-T cell immunotherapy, described the holistic nursing process, and were published in Chinese and English.</p></sec><sec id="j_FON-2019-0014_s_010_w2aab3b7b1b1b6b1aab1c18b3Aa"><h3>Results</h3><p>A total of 6 articles on holistic nursing interventions of CAR-T cell immunotherapy are reported, and the nursing methods and results of each article are analyzed. The quality of the studies included was medium. All nursing measures were considered effective.</p></sec><sec id="j_FON-2019-0014_s_011_w2aab3b7b1b1b6b1aab1c18b4Aa"><h3>Conclusions</h3><p>Holistic nursing programs reduce the incidence of CRS and TLS and improve the quality of life of cancer patients.</p></sec></abstract>

ObjectiveCytokine release syndrome (CRS) and tumor lysis syndrome (TLS) that occur after chimeric antigen receptor T (CAR-T) cells are reinfused, which severely affect the survival and prognosis of patients. Although several articles have reported on the care of CAR-T cell immunotherapy, the quality of the study and the effectiveness of holistic nursing interventions have not been systematically reviewed. The purpose of this study was to systematically evaluate the existing holistic nursing interventions of CAR-T cell immunotherapy.MethodsA literature search for keywords was performed in PubMed, EMBASE, the Cochrane Library, CNKI, CBM, and Wanfang Data from its inception until January 2018. Studies were deemed eligible if they comprised patients with tumor receiving CAR-T cell immunotherapy, described the holistic nursing process, and were published in Chinese and English.ResultsA total of 6 articles on holistic nursing interventions of CAR-T cell immunotherapy are reported, and the nursing methods and results of each article are analyzed. The quality of the studies included was medium. All nursing measures were considered effective.ConclusionsHolistic nursing programs reduce the incidence of CRS and TLS and improve the quality of life of cancer patients.

Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells (CAR-T) immunotherapy: a systematic review of case reports<sup>†</sup>

Frontiers of Nursing

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells (CAR-T) immunotherapy: a systematic review of case reports

ObjectiveCytokine release syndrome (CRS) and tumor lysis syndrome (TLS) that occur after chimeric antigen receptor T (CAR-T) cells are reinfused, which...

Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells (CAR-T) immunotherapy: a systematic review of case reports^†

Article Category: Original article

Published Online: Jul 10, 2019

Page range: 87 - 95

Received: Oct 03, 2018

Accepted: Dec 22, 2018

DOI: https://doi.org/10.2478/FON-2019-0014

Keywords
chimeric antigen receptor T cells, immunotherapy, neoplasms, nursing

© 2019 Xu Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells (CAR-T) immunotherapy: a systematic review of case reports†

Article Category: Original article

Published Online: Jul 10, 2019

Page range: 87 - 95

Received: Oct 03, 2018

Accepted: Dec 22, 2018

DOI: https://doi.org/10.2478/FON-2019-0014

Keywordschimeric antigen receptor T cells, immunotherapy, neoplasms, nursing

© 2019 Xu Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells (CAR-T) immunotherapy: a systematic review of case reports^†

Keywords
chimeric antigen receptor T cells, immunotherapy, neoplasms, nursing