<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A retrospective study was conducted among 498 patients with urinary tract infections (UTI) referred to our department from January 2013 to December 2015. This study was performed to evaluate the etiology of UTI and the antibiotic susceptibility profile of <italic>Escherichia coli</italic> (<italic>E. coli</italic>) as the main etiological factor in different age groups. Urine samples were examined using standard microbiological methods. Three hundred sixty-three samples (72.9%) were identified as <italic>E. coli</italic>, of which 29 (8.0%) can produce extended-spectrum β-lactamases (ESBL). <italic>E. coli</italic> was highly sensitive to imipenem (100.0%), gentamicin (91.0%), nitrofurantoin (89.4%), amikacin (88.2%), piperacillin/ tazobactam (87.0%) and cephalosporins (79.7–89.5%). Low sensitivity was found in relation to fluoroquinolones (60.3–70.4%). <italic>E. coli</italic> was least sensitive to ampicillin (30.2%) and amoxicillin/clavulanic acid (49.9%). We observed a significant fall in susceptibility level to piperacillin/tazobactam (68.4% vs. 88.8%; <italic>p</italic> = 0.017), amikacin (61.1% vs. 90.7%; <italic>p</italic> = 0.001), gentamicin (70.0% vs. 93.2%; <italic>p</italic> = 0.002), cefalexin (41.2% vs. 83.3%; <italic>p</italic> &lt; 0.001), cefotaxime (63.6% vs. 89.4%; <italic>p</italic> = 0.002), ceftazidime (61.9% vs. 85.6%; <italic>p</italic> = 0.008), cefepime (73.7% vs. 91.1%; <italic>p</italic> = 0.025), ciprofloxacin (54.1% vs. 72.2%; <italic>p</italic> = 0.024) and norfloxacin (40.5% vs. 62.5%; <italic>p</italic> = 0.011) among patients with catheter-associated UTI (CAUTI) compared to those with non-CAUTI. A similar susceptibility profile was observed between different age groups. In the longevity, <italic>E. coli</italic> showed a higher sensitivity to cephalosporins than in the young-old group. <italic>E. coli</italic> susceptibility to fluoroquinolones was low, which excludes them as a first-line drug in our department. Nitrofurantoin may be used as an alternative drug to carbapenems. Monitoring of susceptibility pattern is of great importance.</p></abstract>

A retrospective study was conducted among 498 patients with urinary tract infections (UTI) referred to our department from January 2013 to December 2015. This study was performed to evaluate the etiology of UTI and the antibiotic susceptibility profile of Escherichia coli (E. coli) as the main etiological factor in different age groups. Urine samples were examined using standard microbiological methods. Three hundred sixty-three samples (72.9%) were identified as E. coli, of which 29 (8.0%) can produce extended-spectrum β-lactamases (ESBL). E. coli was highly sensitive to imipenem (100.0%), gentamicin (91.0%), nitrofurantoin (89.4%), amikacin (88.2%), piperacillin/ tazobactam (87.0%) and cephalosporins (79.7–89.5%). Low sensitivity was found in relation to fluoroquinolones (60.3–70.4%). E. coli was least sensitive to ampicillin (30.2%) and amoxicillin/clavulanic acid (49.9%). We observed a significant fall in susceptibility level to piperacillin/tazobactam (68.4% vs. 88.8%; p = 0.017), amikacin (61.1% vs. 90.7%; p = 0.001), gentamicin (70.0% vs. 93.2%; p = 0.002), cefalexin (41.2% vs. 83.3%; p < 0.001), cefotaxime (63.6% vs. 89.4%; p = 0.002), ceftazidime (61.9% vs. 85.6%; p = 0.008), cefepime (73.7% vs. 91.1%; p = 0.025), ciprofloxacin (54.1% vs. 72.2%; p = 0.024) and norfloxacin (40.5% vs. 62.5%; p = 0.011) among patients with catheter-associated UTI (CAUTI) compared to those with non-CAUTI. A similar susceptibility profile was observed between different age groups. In the longevity, E. coli showed a higher sensitivity to cephalosporins than in the young-old group. E. coli susceptibility to fluoroquinolones was low, which excludes them as a first-line drug in our department. Nitrofurantoin may be used as an alternative drug to carbapenems. Monitoring of susceptibility pattern is of great importance.

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A retrospective study was conducted among 498 patients with urinary tract infections (UTI) referred to our department from January 2013 to December 2015. This...

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland

Article Category: original-paper

Published Online: Dec 10, 2018

Page range: 517 - 524

Received: May 22, 2018

Accepted: Oct 08, 2018

DOI: https://doi.org/10.21307/pjm-2018-061

Keywords
urinary tract infection (UTI), antimicrobial susceptibility testing (AST)

© 2018 Mikołaj Michno et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland

Article Category: original-paper

Published Online: Dec 10, 2018

Page range: 517 - 524

Received: May 22, 2018

Accepted: Oct 08, 2018

DOI: https://doi.org/10.21307/pjm-2018-061

Keywordsurinary tract infection (UTI), antimicrobial susceptibility testing (AST)

© 2018 Mikołaj Michno et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
urinary tract infection (UTI), antimicrobial susceptibility testing (AST)