<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2015-0017_s_001"><h3>Introduction</h3><p>Epilepsy that is associated with neurocutaneous disorders seriously deteriorates quality of life and cognitive outcome of affected children. Recent advances in epilepsy pathophysiology raise hopes for better treatment results in this difficult group of patients.</p></sec><sec id="j_joepi-2015-0017_s_002"><h3>Aim</h3><p>The aim of this review is to present recent treatment recommendations as well as current research progress in the most frequent neurocutaneous disorders.</p></sec><sec id="j_joepi-2015-0017_s_003"><h3>Material and methods</h3><p>We analyzed PubMed database to select the most prominent and recent (up to 2014 year) publications on the treatment and mechanisms of epilepsy in selected neurocutaneous disorders. We aimed to emphasize evidence-based medicine recommendations as well as basic experimental studies dealing with molecular mechanisms of epileptogenesis.</p></sec><sec id="j_joepi-2015-0017_s_004"><h3>Discussion and conclusions</h3><p>Recent advances in disease-modifying treatment options such as mTOR inhibitors in patients with tuberous sclerosis complex open up new perspectives for neurologists. Traditional resective surgery has still a major role as a treatment of choice in carefully selected cases.</p></sec></abstract>

IntroductionEpilepsy that is associated with neurocutaneous disorders seriously deteriorates quality of life and cognitive outcome of affected children. Recent advances in epilepsy pathophysiology raise hopes for better treatment results in this difficult group of patients.AimThe aim of this review is to present recent treatment recommendations as well as current research progress in the most frequent neurocutaneous disorders.Material and methodsWe analyzed PubMed database to select the most prominent and recent (up to 2014 year) publications on the treatment and mechanisms of epilepsy in selected neurocutaneous disorders. We aimed to emphasize evidence-based medicine recommendations as well as basic experimental studies dealing with molecular mechanisms of epileptogenesis.Discussion and conclusionsRecent advances in disease-modifying treatment options such as mTOR inhibitors in patients with tuberous sclerosis complex open up new perspectives for neurologists. Traditional resective surgery has still a major role as a treatment of choice in carefully selected cases.

Recent advances in pathophysiology studies and treatment of epilepsy in neurocutaneous disorders

Journal of Epileptology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

IntroductionEpilepsy that is associated with neurocutaneous disorders seriously deteriorates quality of life and cognitive outcome of affected children. Recent...

Recent advances in pathophysiology studies and treatment of epilepsy in neurocutaneous disorders

Published Online: Oct 13, 2014

Page range: 99 - 108

Received: Jul 24, 2014

Accepted: Oct 03, 2014

DOI: https://doi.org/10.21307/joepi-2015-0017

Keywords
epilepsy, neurocutaneous disorders, tuberous sclerosis, pathogenesis, treatment recommendation

© 2014 Lauren B. Bolden et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Recent advances in pathophysiology studies and treatment of epilepsy in neurocutaneous disorders

Published Online: Oct 13, 2014

Page range: 99 - 108

Received: Jul 24, 2014

Accepted: Oct 03, 2014

DOI: https://doi.org/10.21307/joepi-2015-0017

Keywordsepilepsy, neurocutaneous disorders, tuberous sclerosis, pathogenesis, treatment recommendation

© 2014 Lauren B. Bolden et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
epilepsy, neurocutaneous disorders, tuberous sclerosis, pathogenesis, treatment recommendation