<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Dithiothreitol (DTT) and 2-mercaptoethanol (2-ME) are sulfhydryl compounds that can be used to treat serum or plasma to denature IgM antibody reactivity. By using sulfhydryl agents, IgG and IgM antibodies can be separated, the relative amount of IgM and IgG antibodies can be determined, and the risk of hemolytic disease of the fetus and newborn can be assessed. <italic><bold>Immunohematology</bold></italic> <bold>2018;34:135–139.</bold></p>
</abstract>

Dithiothreitol (DTT) and 2-mercaptoethanol (2-ME) are sulfhydryl compounds that can be used to treat serum or plasma to denature IgM antibody reactivity. By using sulfhydryl agents, IgG and IgM antibodies can be separated, the relative amount of IgM and IgG antibodies can be determined, and the risk of hemolytic disease of the fetus and newborn can be assessed. Immunohematology 2018;34:135–139.

Sulfhydryl treatment of serum or plasma for the reduction of IgM antibodies

Immunohematology

{"article-title":"Sulfhydryl treatment of serum or plasma for the reduction of IgM antibodies"}

Dithiothreitol (DTT) and 2-mercaptoethanol (2-ME) are sulfhydryl compounds that can be used to treat serum or plasma to denature IgM antibody reactivity. By...

Sulfhydryl treatment of serum or plasma for the reduction of IgM antibodies

Published Online: Oct 16, 2019

Page range: 135 - 139

DOI: https://doi.org/10.21307/immunohematology-2018-021

© 2018 L.N. Blagg, published by Sciendo