Phenotype | Vancomycin MIC (mg/L) | Teicoplanin MIC (mg/L) | Modification | Localization | Transfer capibility | Expression | Major species |
---|---|---|---|---|---|---|---|
VanA | 64–1000 | 16–512 | d-Ala-d-Lac | Plasmid or chromosome | yes | induced |
|
VanB | 4–1000 | 0.5–1 | d-Ala-d-Lac | Plasmid or chromosome | yes | induced |
|
VanC | 2–32 | 0.5–1 | d-Ala-d-Ser | chromosome | no | Constitutive or induced |
|
VanD | 64–128 | 4–64 | d-Ala-d-Lac | Plasmid or chromosome | no | Constitutive or induced |
|
VanE | 8–32 | 0.5 | d-Ala-d-Ser | chromosome | no | induced |
|
VanG | ≤ 16 | wrażliwy | d-Ala-d-Ser | chromosome | yes | induced |
|
VanL | 8 | ≤ 0.5 | d-Ala-d-Ser | chromosome | no | induced |
|
VanM | > 256 | 96 | d-Ala-d-Lac | Plasmid or chromosome | yes | induced |
|
VanN | 16 | ≤ 0.5 | d-Ala-d-Ser | plasmid | yes | constitutive |
|
Percentages of vancomycin-resistant |
2012 | 2015 |
---|---|---|
Below 1% | Iceland, Norway, Sweden, Finland, Estonia, the Netherlands, France, Slovenia, Croatia, Bulgaria | Iceland, Norway, Sweden, Finland, Estonia, France, Belgium |
1–5% | Spain, Belgium, Denmark, Austria, Slovakia, Hungary, Romania | Spain, Denmark, the Netherlands, Austria, Slovenia |
5–10% | Latvia, Lithuania, Poland, Italy | Czechia (Czech Republic) |
10–25% | Great Britain, Portugal, Germany, Czechia (Czech Republic), Greece, Cyprus | Great Britain, Portugal, Germany, Poland, Latvia, Lithuania, Slovakia, Hungary, Italy, Bulgaria, Greece |
25–50% | Ireland | Ireland, Croatia, Romania, Cyprus |
over 50% | – | – |
Year | No. of isolates | Percentage of all alarming factors |
---|---|---|
2016 | 50 | 1.14% |
2015 | 34 | 0.81% |
2014 | No data | No data |
2013 | 18 | 0.44% |
2012 | 11 | 0.33% |
Enterococci strains | Drug used | MIC (μg/ml) | % of resistant isolates | |
---|---|---|---|---|
50% | 90% | |||
VanA and VanB strains | Daptomycin | 4 | 8 | Not determined |
Linezolid | 2 | 2 | 1.5 | |
Quinupristin/dalfopristin | 0.5 | 1 | 6.0 | |
Ampicillin | 64 | 128 | 93.2 | |
Doxycycline | 4 | 16 | 14.2 | |
Vancomycin | > 128 | > 128 | 100 | |
VanC1 and VanC2 strains | Daptomycin | 1 | 2 | Not determined |
Linezolid | 2 | 2 | 0 | |
Quinupristin/dalfopristin | 2 | 2 | 0 | |
Ampicillin | 0.5 | 1 | 0 | |
Doxycycline | ≤ 0.25 | ≤ 0.25 | 4.5 | |
Vancomycin | 4 | 4 | 0 |