<abstract xmlns="http://www.w3.org/1999/xhtml">Free living, cosmopolitan amoebae of the genus <italic>Acanthamoeba</italic> present a serious risk to human health. As facultative human parasites, these amoebae may cause health and life-threatening diseases, such as <italic>Acanthamoeba</italic> keratitis (AK), granulomatous amoebic encephalitis (GAE) and cutaneous acanthamebiasis. AK is a severe, vision-threatening cornea infection with non-specific symptoms and course. GAE is a unique central nervous system disease, almost always leading to death. Cutaneous acanthamebiasis is most common in patients with AIDS. The pathogenesis and pathophysiology of the diseases is still incompletely understood, therefore no definitive effective therapy is currently available. Prevention is very difficult due to<italic>Acanthamoeba</italic> ubiquity and resistance. Further studies on effective solutions for the prevention and treatment of <italic>Acanthamoeba</italic> infections are needed.1. Introduction. 2. Genus <italic>Acanthamoeba</italic>. 2.1. Occurrence. 2.2. Pathogenicity. 3. <italic>Acanthamoeba</italic> keratitis – AK. 3.1. Risk factors. 3.2. Course of the disease. 3.3. Diagnostics. 3.4. Treatment and prevention. 4. Granulomatous amebic encephalitis – GAE. 4.1. Course of disease. 4.2. Diagnostics and treatment. 5.Cutaneousacanthamebiasis. 5.1. Course of disease. 5.2. Diagnostics and treatment. 6. Summary</abstract>

Free living, cosmopolitan amoebae of the genus Acanthamoeba present a serious risk to human health. As facultative human parasites, these amoebae may cause health and life-threatening diseases, such as Acanthamoeba keratitis (AK), granulomatous amoebic encephalitis (GAE) and cutaneous acanthamebiasis. AK is a severe, vision-threatening cornea infection with non-specific symptoms and course. GAE is a unique central nervous system disease, almost always leading to death. Cutaneous acanthamebiasis is most common in patients with AIDS. The pathogenesis and pathophysiology of the diseases is still incompletely understood, therefore no definitive effective therapy is currently available. Prevention is very difficult due toAcanthamoeba ubiquity and resistance. Further studies on effective solutions for the prevention and treatment of Acanthamoeba infections are needed.1. Introduction. 2. Genus Acanthamoeba. 2.1. Occurrence. 2.2. Pathogenicity. 3. Acanthamoeba keratitis – AK. 3.1. Risk factors. 3.2. Course of the disease. 3.3. Diagnostics. 3.4. Treatment and prevention. 4. Granulomatous amebic encephalitis – GAE. 4.1. Course of disease. 4.2. Diagnostics and treatment. 5.Cutaneousacanthamebiasis. 5.1. Course of disease. 5.2. Diagnostics and treatment. 6. Summary

Amoebae of the genus <italic>Acanthamoeba –</italic> pathological agents in humans

Advancements of Microbiology

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Amoebae of the genus  pathological agents in humans

<trans-abstract xml:lang="pl" xmlns="http://www.w3.org/1999/xhtml">1. Wprowadzenie. 2. Rodzaj <italic>Acanthamoeba</italic>. 2.1. Występowanie. 2.2. Chorobotwórczość. 3. Pełzakowe zapalenie rogówki – AK. 3.1. Czynniki ryzyka. 3.2. Przebieg zarażenia. 3.3. Diagnostyka. 3.4. Leczenie i profilaktyka. 4. Ziarniniakowe pełzakowe zapalenie mózgu – GAE. 4.1. Przebieg zarażenia. 4.2. Diagnostyka i leczenie. 5. Akantameboza skórna. 5.1. Przebieg zarażenia. 5.2. Diagnostyka i leczenie. 6. Podsumowanie</trans-abstract>

1. Wprowadzenie. 2. Rodzaj Acanthamoeba. 2.1. Występowanie. 2.2. Chorobotwórczość. 3. Pełzakowe zapalenie rogówki – AK. 3.1. Czynniki ryzyka. 3.2. Przebieg zarażenia. 3.3. Diagnostyka. 3.4. Leczenie i profilaktyka. 4. Ziarniniakowe pełzakowe zapalenie mózgu – GAE. 4.1. Przebieg zarażenia. 4.2. Diagnostyka i leczenie. 5. Akantameboza skórna. 5.1. Przebieg zarażenia. 5.2. Diagnostyka i leczenie. 6. Podsumowanie

Free living, cosmopolitan amoebae of the genus Acanthamoeba present a serious risk to human health. As facultative human parasites, these amoebae may cause...

Amoebae of the genus Acanthamoeba – pathological agents in humans

Published Online: May 22, 2019

Page range: 429 - 439

Received: Jun 01, 2017

Accepted: Sep 01, 2017

DOI: https://doi.org/10.21307/PM-2017.56.4.429

2017 @ Author., Published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.