Open Access

Anti-fibrinolytic agents in bleeding disorders – A clinical perspective


Cite

1. Reiner, Alexander Paul et al. The fibrinolytic system in man. Critical Reviews in Oncology / Hematology, Volume 2 , Issue 1 , 33 - 8110.1016/S1040-8428(84)80004-9Search in Google Scholar

2. Raza I, Davenport R, Rourke C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 2013; 11(2): 307-14.10.1111/jth.12078Open DOISearch in Google Scholar

3. Okamoto S. Plasmin and antiplasmin. Their pathologic physiology. Keio J Med 1959; 8: 211-7.Search in Google Scholar

4. Okamoto S, Okamoto U. Amino-methyl-cyclohexane-carboxylic acid: AMCHA: a new potent inhibitor of fibrinolysis. Keio J Med 1962; 11: 105-15.10.2302/kjm.11.105Search in Google Scholar

5. Shakur H, Elbourne D, Gülmezoglu M, et al. The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. Trials 2010, 11: 40.10.1186/1745-6215-11-40Search in Google Scholar

6. Dewan Y, Komolafe EO, Mejía-Mantilla JH, et al. CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo controlled trial. Trials 2012; 13: 87.10.1186/1745-6215-13-87Open DOISearch in Google Scholar

7. Roberts I, Coats T, Edwards P, et al. HALT-IT - tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial. Trials 2014; 15: 450.10.1186/1745-6215-15-450Open DOISearch in Google Scholar

8. Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 2011; 377: 1096-101.10.1016/S0140-6736(11)60278-XSearch in Google Scholar

9. Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376: 23-32.10.1016/S0140-6736(10)60835-5Search in Google Scholar

10. Rea CJ, Foley JH, Ingerslev J, Sørensen B. Factor XIII combined with recombinant factor VIIa: a new means of treating severe hemophilia A. J Thromb Haemost 2011; 9: 510-6.10.1111/j.1538-7836.2010.04171.x21155966Search in Google Scholar

11. Rea CJ, Foley JH, Okaisabor O, Sørensen B. FXIII: mechanisms of action in the treatment of hemophilia A. J Thromb Haemost 2014; 12: 159-68.10.1111/jth.1247824354581Open DOISearch in Google Scholar

12. Brummel-Ziedins KE, Branda RF, Butenas S, Mann KG. Discordant fibrin formation in hemophilia. J Thromb Haemost 2009; 7: 825-32.10.1111/j.1538-7836.2009.03306.xOpen DOISearch in Google Scholar

13. Foley JH, Nesheim ME, Rivard GE, Brummel-Ziedins KE. Thrombin activatable fibrinolysis inhibitor activation and bleeding in haemophilia A. Haemophilia 2012; 18: e316-22.10.1111/j.1365-2516.2011.02648.xOpen DOISearch in Google Scholar

14. Hvas A-M, Sørensen HT, Norengaard L, Christiansen K, Ingerslev J, Sørensen B. Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A. J Thromb Haemost 2007; 5: 2408-14..10.1111/j.1538-7836.2007.02755.xOpen DOISearch in Google Scholar

15. Bisordi MV. Peanut flour in haemophilia. Lancet 1964; 2: 476.10.1016/S0140-6736(64)90371-XOpen DOISearch in Google Scholar

16. Bruster H. Klin Wochenschr 1961; 39: 1145.Search in Google Scholar

17. Verstraete M, Ruys CA. Double-blind experiments on the effect of a peanut extract on the bleeding incidence in 92 haemophiliacs. Br Med J 1967; 4: 453-6.10.1136/bmj.4.5577.45317485614861744Search in Google Scholar

18. Bennett AE, Ingram GI, Inglish PJ. Antifibrinolytic treatment in haemophilia: a controlled trial of prophylaxis with tranexamic acid. Br J Haematol 1973 ;24(1): 83-8.10.1111/j.1365-2141.1973.tb05729.x4577064Search in Google Scholar

19. Ingram GI, Inglish PJ, Bennet AE. Tranexamic acid for prophylaxis in haemophilia. J Clin Pathol 1972 ; 25(7): 629.10.1136/jcp.25.7.6294774524560842Open DOISearch in Google Scholar

20. Gordon AM, McNicol GP, Dubber AHC, McDonald GA, Douglas AS. Clinical trial of epsilon-aminocaproic acid in severe haemophilia. Br Med J 1965; 1(5451): 1632-5.10.1136/bmj.1.5451.1632216705014295319Search in Google Scholar

21. Hermans C, Altisent C, Batorova A, et al. Replacement therapy for invasive procedures in patients with haemophilia: literature review, European survey and recommendations. Haemophilia 2009; 15: 639-58.10.1111/j.1365-2516.2008.01950.x19444969Open DOISearch in Google Scholar

22. Schulman S, Loogna J, Wallensten R. Minimizing factor requirements for surgery without increased risk. Haemophilia 2004; 10(Suppl. 4): 35-40Search in Google Scholar

23. Tavenner RW. Use of tranexamic acid in control of haemorrhage after extraction of teeth in haemophilia and Christmas disease. Br Med J 1972;2(5809): 314-5.10.1136/bmj.2.5809.31417881904537105Search in Google Scholar

24. Forbes CD, Barr RD, Reid G, Thomson C, Prentice CR, McNicol GP, Douglas AS. Tranexamic acid in control of haemorrhage after dental extraction in haemophilia and Christmas disease. Br Med J 1972 ;2(5809): 311-3.10.1136/bmj.2.5809.311Search in Google Scholar

25. Walsh PN, Rizza CR, Evans BE, Aledort LM. The therapeutic role of epsilon-aminocaproic acid (EACA) for dental extractions in hemophiliacs. Ann N Y Acad Sci 1975; 240: 267-76.10.1111/j.1749-6632.1975.tb53359.xSearch in Google Scholar

26. Walsh PN, Rizza CR, Matthews JM, et al. Epsilon-aminocaproic acid therapy for dental extractions in haemophilia and Christmas disease: a double blind controlled trial. Br J Haematol 1971; 20(5): 463-75.10.1111/j.1365-2141.1971.tb07061.xSearch in Google Scholar

27. Sindet-Pedersen S, Stenbjerg S. Effect of local antifibrinolytic treatment with tranexamic acid in hemophiliacs undergoing oral surgery. J Oral Maxillofac Surg 1986; 44(9): 703-7.10.1016/0278-2391(86)90039-XSearch in Google Scholar

28. Waly NG. Local antifibrinolytic treatment with tranexamic acid in hemophilic children undergoing dental extractions. Egypt Dent J 1995; 41(1): 961-8.Search in Google Scholar

29. Nuvvula S, Gaddam KR, Kamatham R. Efficacy of tranexamic acid mouthwash as an alternative for factor replacement in gingival bleeding during dental scaling in cases of hemophilia: a randomized clinical trial. Contemp Clin Dent 2014; 5(1): 49-53.10.4103/0976-237X.128663401211724808695Search in Google Scholar

30. Laffan MA, Lester W, O’Donnell JS, et al. The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology. Br J Haematol 2014; 167: 453-65.10.1111/bjh.13064428348325113304Search in Google Scholar

31. Davis A, Walsh M, McCarthy P, et al. Tranexamic acid without prophylactic factor replacement for prevention of bleeding in hereditary bleeding disorder patients undergoing endoscopy: a pilot study. Haemophilia 2013; 19: 583-9.10.1111/hae.1214623560720Open DOISearch in Google Scholar

32. Coppola A, Windyga J, Tufano A, Yeung C, Di Minno MN. Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery. Cochrane Database Syst Rev 2015; (2): CD009961.10.1002/14651858.CD009961.pub225922858Search in Google Scholar

33. Bennett C, Klingenberg SL, Langholz E, Gluud LL. Tranexamic acid for upper gastrointestinal bleeding. Cochrane Database Syst Rev 2014; (11): CD006640.10.1002/14651858.CD006640.pub3659982525414987Search in Google Scholar

34. van Galen KPM, Engelen ET, Mauser-Bunschoten EP, van Es RJ, Schutgens RE. Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions. Cochrane Database Syst Rev 2015; (12): CD011385.10.1002/14651858.CD011385.pub226704192Search in Google Scholar

35. Negrier C, Goudemand J, Sultan Y, Bertrand M, Rothschild C, Lauroua P. Multicenter retrospective study on the utilization of FEIBA in France in patients with factor VIII and factor IX inhibitors. French FEIBA Study Group. Factor Eight Bypassing Activity. Thromb Haemost 1997; 77: 1113-9.Search in Google Scholar

36. Astermark J, Donfield SM, DiMichele DM et al. A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study. Blood 2007; 109: 546-51 Epub 2006; doi 10.1182/blood-2006-04-01798.10.1182/blood-2006-04-01798Open DOISearch in Google Scholar

37. Dai L, Bevan D, Rangarajan S, Sørensen B, Mitchell M. Stabilization of fibrin clots by activated prothrombin complex concentrate and tranexamic acid in FVIII inhibitor plasma. Haemophilia 2011; 17: e944-8.10.1111/j.1365-2516.2011.02491.x21371192Search in Google Scholar

38. Holmström M, Tran HT, Holme PA. Combined treatment with APCC (FEIBA®) and tranexamic acid in patients with haemophilia A with inhibitors and in patients with acquired haemophilia A - a two-centre experience. Haemophilia 2012; 18: 544-9.10.1111/j.1365-2516.2012.02748.x22348384Open DOISearch in Google Scholar

39. Tran HT, Sørensen B, Rea CJ, et al. Tranexamic acid as adjunct therapy to bypassing agents in haemophilia A patients with inhibitors. Haemophilia 2014; 20: 369-75.10.1111/hae.1231824251535Open DOISearch in Google Scholar

40. Kouides PA, Byams VR, Philipp CS, et al. Multisite management study of menorrhagia with abnormal laboratory haemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid. Br J Haematol 2009; 145: 212-20.10.1111/j.1365-2141.2009.07610.x19236375Search in Google Scholar

41. Mohri H. High dose of tranexamic acid for treatment of severe menorrhagia in patients with von Willebrand disease. J Thromb Thrombolysis 2002; 14(3): 255-7.10.1023/A:1025013213192Search in Google Scholar

42. Rybo G. Tranexamic acid therapy: effective treatment in heavy menstrual bleeding: clinical update on safety. Therapeutic Advances 1991; 4: 1-8.Search in Google Scholar

43. Lindoff C, Rybo G, Astedt B. Treatment with tranexamic acid during pregnancy, and the risk of thrombo-embolic complications. Thromb Haemost 1993; 70(2): 238-40.10.1055/s-0038-1649475Search in Google Scholar

44. Kadir RA, Lee CA, Sabin CA, Pollard D, Economides DL. Pregnancy in women with von Willebrand’s disease or factor XI deficiency. Br J Obstet Gynaecol 1998; 105(3): 314-21.10.1111/j.1471-0528.1998.tb10093.x9532993Search in Google Scholar

45. Ducloy-Bouthors AS, Jude B, Duhamel A, et al. High-dose tranexamic acid reduces blood loss in postpartum haemorrhage. Crit Care 2011; 15(2): R117.10.1186/cc10143321940021496253Open DOISearch in Google Scholar

46. Lee CA, Chi C, Pavord SR, et al. The obstetric and gynaecological management of women with inherited bleeding disorders - review with guidelines produced by a taskforce of UK Haemophilia Centre Doctors’ Organization. Haemophilia 2006; 12: 301-36.10.1111/j.1365-2516.2006.01314.x16834731Open DOISearch in Google Scholar

eISSN:
2055-3390
Language:
English
Publication timeframe:
Volume Open
Journal Subjects:
Medicine, Basic Medical Science, other, Clinical Medicine, Pharmacy, Pharmacology