Does sickle cell trait reduce the frequency of spontaneous bleeds in severe haemophilia?

1. Tantawy AAG. Molecular genetics of hemophilia-A: clinical perspectives. Egypt J Med Hum Genet 2010;11:105-14. doi:10.1016/j. ejmhg.2010.10.005.Search in Google Scholar

2. Kujovich JL. Factor V Leiden thrombophilia. Genet Med 2011;13:1-6. doi:10.1097/GIM.0b013e3181faa0f2.Search in Google Scholar

3. Franchini M, Lippi G. Factor V Leiden and hemophilia. Thromb Res 2010;125:119-23. doi:10.1016/j.thromres.2009.11.003.Search in Google Scholar

4. Flint J, Harding RM, Boyce AJ, Clegg JB. The population genetics of the haemoglobinopathies. Bailliere’s Clin Haematol 1993;6:215-22.10.1016/S0950-3536(05)80071-XSearch in Google Scholar

5. Ahmed SG, Ibrahim UA. Haemoglobin-S in sickle cell trait with papillary necrosis. Br J Haematol 2006;135:415-6.10.1111/j.1365-2141.2006.06318.x16984389Search in Google Scholar

6. Barbedo MMR, McCurdy PR. Red cell life span in sickle cell trait. Acta Haematol 1974;15:339-42.Search in Google Scholar

7. Fleming AF, Storey J, Molineaux L et al. Abnormal haemoglobins in the Sudan Savannah area of Nigeria: prevalence of haemoglobin variants and relationship between sickle cell trait, malaria and survival. Ann Trop Med Parasitol 1979;73:161-72.10.1080/00034983.1979.11687243315211Search in Google Scholar

8. Hood AT. Protection against lethal malaria in transgenic mice expressing sickle cell haemoglobin. Blood 1996;87:1600-3.10.1182/blood.V87.4.1600.bloodjournal8741600Search in Google Scholar

9. Galadanci N, Wudil BJ, Balogun TM et al. Current sickle cell disease management practices in Nigeria. Int Health 2014;6:23-8. doi:10.1093/inthealth/iht022.Search in Google Scholar

10. Humphries JE, Wheby MS. Case report: sickle cell trait and recurrent deep venous thrombosis. Am J Med Sci 1992;303:112-4.10.1097/00000441-199202000-000101539607Search in Google Scholar

11. Austin H, Key NS, Benson JM et al. Sickle cell trait and the risk of venous thromboembolism among blacks. Blood 2007;110:908-12.10.1182/blood-2006-11-05760417409269Search in Google Scholar

12. Ahmed SG, Kagu MB, Ibrahim UA, Bukar AA. Impact of sickle cell trait on the thrombotic risk associated with non-O blood groups in northern Nigeria. Blood Transfus 2015;13:639-43. doi:10.2450/2015.0335-14.Search in Google Scholar

13. Folsom AR, Tang W, Roetker NS et al. Prospective study of sickle cell trait and venous thromboembolism incidence. J Thromb Haemost 2015;13:2-9.10.1111/jth.12787429497625393788Search in Google Scholar

14. Austin H, Lally C, Benson JM et al. Hormonal contraception, sickle cell trait, and risk for venous thromboembolism among African American women. Am J Obstet Gynecol 2009;200:620.e1-3.10.1016/j.ajog.2009.01.03819306959Search in Google Scholar

15. Saxena P, Dhiman P, Bihari C, Rastogi A. Sickle cell trait causing splanchnic venous thrombosis. Case Reports Hepatol 2015:743289. doi:10.1155/2015/743289.Search in Google Scholar

16. Ramesh N, Suliman S, Alkhoury Z. Cerebral venous thrombosis in sickle cell trait-a rare entity. J Hosp Med 2013;8(suppl 2). Available from http://www.shmabstracts.com/abstract/cerebral-venous-thrombosis-in-sicklecell-trait-a-rare-entity/ (accessed 4 June 2016).Search in Google Scholar

17. Feldenzer JA, Bueche MJ, Venes JL, Gebarski SS. Superior sagittal sinus thrombosis with infarction in sickle cell trait. Stroke 1987;18:656-60.10.1161/01.STR.18.3.656Open DOISearch in Google Scholar

18. Pintova S, Cohen HW, Billett HH. Sickle cell trait: is there an increased VTE risk in pregnancy and the postpartum? PLoS ONE 2013;8:e64141.10.1371/journal.pone.0064141366143723717554Search in Google Scholar

19. Westerman MP, Green D, Gilman-Sachs A et al. Coagulation changes in individuals with sickle cell trait. Am J Hematol 2002;69:89-94. doi: 10.1002/ajh.10021.Search in Google Scholar

20. O’Mahony B, Black C. Expanding hemophilia care in developing countries. Semin Thromb Hemost 2005;31:561-8.10.1055/s-2005-92222816276465Search in Google Scholar

21. Laffan M, Manning R. Investigation of haemostasis. In: Lewis SM, Bain BJ, Bates I (eds). Practical Haematology, 10th edn. London, Churchill Livingstone; 2006: 379-440.10.1016/B0-44-306660-4/50020-9Search in Google Scholar

22. Wild B, Bain BJ. Investigation of abnormal haemoglobins and thalassaemia. In: Lewis SM, Bain BJ, Bates I (eds). Practical Haematology, 10th edn. London, Churchill Livingstone; 2006: 271-310.10.1016/B0-44-306660-4/50016-7Search in Google Scholar

23.Qasim Z, Asif N, Hassan K. Pattern of bleeding in haemophilia patients. J Islamabad Medical & Dental College 2014;3:3-6.Search in Google Scholar

24. Sletnes KE. [Role of phospholipids in hemostasis]. Tidsskr Nor Laegeforen 1993;113:2238-41.Search in Google Scholar

25. Tait JF, Gibson D. Measurement of membrane phospholipid asymmetry in normal and sickle-cell erythrocytes by means of annexin V binding. J Lab Clin Med 1994;123:741-8.Search in Google Scholar

26. Westerman MP, Cole ER, Wu K. The effect of spicules obtained from sickle red cells on clotting activity. Br J Haematol 1984;56:557-62.10.1111/j.1365-2141.1984.tb02180.x6424699Search in Google Scholar