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The purpose of the study is to substantiate the directions of activation of the innovative development of economic systems in the digitalization conditions. The methodological basis of the research is the systematic approach, which makes it possible to determine the effectiveness of the functioning of the innovation system in the digitalization conditionsas a quantity qualitatively and quantitatively greater than the effectiveness of the sum of its components, to investigate the interrelationships of the system elements and the possibilities of its development, taking into account changes in the external environment. The principles of innovative development of economic systems in conditions of digitalization are highlighted, which include adaptability, creativity and digital transformation. It has been proven that the majority of innovative processes use non-linear methods of innovative development due to the formation of network systems, the development of new global markets and the use of digital technologies. The general factors restraining the innovative development of economic systems in the digitalization conditions are singled out. The need for the formation of an innovative system based on the principles of digitalization and the main approaches to its formation, which adhere to the principles of its development, are substantiated.