Open Access

The Assessment of short-term effect of L-Citrulline on endothelial function via FMD to NMD ratio in known CAD patients: A randomized, cross-over clinical trial (Clinical trial number: NCT02638727)


Cite

1. ABOU-MOHAMED G., JOHNSON JA., JIN L., EL-REMESSY AB., DO K., KAESEMEYER WH., et al. Roles of superoxide, peroxynitrite, and protein kinase C in the development of tolerance to nitroglycerin. J Pharmacol Exp Ther. 2004; 308 (1):289-99.10.1124/jpet.103.056119Search in Google Scholar

2. ASAGA H., ISHIGAMI A. Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration. Neurosci Lett. 2001; 299 (1-2):5-8.10.1016/S0304-3940(00)01735-3Search in Google Scholar

3. BAYDOUN AR., BOGLE RG., PEARSON JD., MANN GE. Discrimination between citrulline and arginine transport in activated murine macrophages: inefficient synthesis of NO from recycling of citrulline to arginine. Br J Pharmacol. 1994; 112 (2):487-92.10.1111/j.1476-5381.1994.tb13099.xSearch in Google Scholar

4. BERKOWITZ DE., WHITE R., LI D., MINHAS KM., CERNETICH A., KIM S., et al. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation. 2003; 108 (16):2000-6.10.1161/01.CIR.0000092948.04444.C7Search in Google Scholar

5. DILLON EL., KNABE DA., WU G. Lactate inhibits citrulline and arginine synthesis from proline in pig enterocytes. Am J Physiol. 1999; 276 (5 Pt 1):G1079-86.10.1152/ajpgi.1999.276.5.G1079Search in Google Scholar

6. DONG S., KOJIMA T., SHIRAIWA M., MECHIN MC., CHAVANAS S., SERRE G., et al. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. J Invest Dermatol. 2005; 124 (5):1026-33.10.1111/j.0022-202X.2005.23690.xSearch in Google Scholar

7. INOUE Y., COPELAND EM., SOUBA WW. Growth hormone enhances amino acid uptake by the human small intestine. Ann Surg. 1994; 219 (6):715-22; discussion 22-4.10.1097/00000658-199406000-00016Search in Google Scholar

8. ISHIGAMI A., OHSAWA T., ASAGA H., AKIYAMA K., KURAMOTO M., MARUYAMA N. Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. Arch Biochem Biophys. 2002; 407 (1):25-31.10.1016/S0003-9861(02)00516-7Search in Google Scholar

9. CREAGER MA., COOKE JP., MENDELSOHN ME., GALLAGHER SJ., COLEMAN SM., LOSCALZO J., et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990; 86 (1):228-34.10.1172/JCI1146882967112195060Search in Google Scholar

10. CURIS E., NICOLIS I., MOINARD C., OSOWSKA S., ZERROUK N., BENAZETH S., et al. Almost all about citrulline in mammals. Amino Acids. 2005; 29 (3):177-205.10.1007/s00726-005-0235-416082501Search in Google Scholar

11. JEAN C., ROME S., MATHE V., HUNEAU JF., AATTOURI N., FROMENTIN G., et al. Metabolic evidence for adaptation to a high protein diet in rats. J Nutr. 2001; 131 (1):91-8.10.1093/jn/131.1.9111208943Search in Google Scholar

12. JEREMY RW., MCCARRON H., SULLIVAN D. Effects of dietary L-arginine on atherosclerosis and endothelium-dependent vasodilatation in the hypercholesterolemic rabbit. Response according to treatment duration, anatomic site, and sex. Circulation. 1996; 94 (3):498-506.10.1161/01.CIR.94.3.498Search in Google Scholar

13. SANCHEZ-GONZALEZ MA., KOUTNIK AP., RAMIREZ K., WONG A., FIGUEROA A. The effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exercise. Am J Hypertens. 2013; 26 (4):518-26.10.1093/ajh/hps05223467207Search in Google Scholar

14. OREA-TEJEDA A., OROZCO-GUTIERREZ JJ., CASTILLO-MARTINEZ L., KEIRNS-DAVIES C., MONTANOHERNANDEZ P., VAZQUEZ-DIAZ O., et al. The effect of L-arginine and citrulline on endothelial function in patients in heart failure with preserved ejection fraction. Cardiol J. 2010; 17 (5):464-70.Search in Google Scholar

15. BALDERAS-MUNOZ K., CASTILLO-MARTINEZ L., OREA-TEJEDA A., INFANTE-VAZQUEZ O., UTRERA-LAGUNAS M., MARTINEZ-MEMIJE R., et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J. 2012; 19 (6):612-7.10.5603/CJ.2012.0113Search in Google Scholar

16. IKEDA Y., YOUNG LH., SCALIA R., LEFER AM. Cardioprotective effects of citrulline in ischemia/reperfusion injury via a non-nitric oxide-mediated mechanism. Methods Find Exp Clin Pharmacol. 2000; 22 (7):563-71.10.1358/mf.2000.22.7.802268Search in Google Scholar

17. OROZCO-GUTIERREZ JJ., CASTILLO-MARTINEZ L., OREA-TEJEDA A., VAZQUEZ-DIAZ O., VALDESPINO-TREJO A., NARVAEZ-DAVID R., et al. Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J. 2010; 17 (6):612-8.Search in Google Scholar

eISSN:
2501-062X
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, other, Cardiology, Gastroenterology, Rheumatology