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PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung

Urska Janzic

Urska Janzic

Department of Medical Oncology, University Clinic GolnikGolnik, Slovenia
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Janzic, Urska
, 
Izidor Kern

Izidor Kern

Department of Pathology, University Clinic GolnikGolnik, Slovenia
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Kern, Izidor
, 
Andrej Janzic

Andrej Janzic

University of Ljubljana, Faculty of PharmacyLjubljana, Slovenia
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Janzic, Andrej
, 
Luka Cavka

Luka Cavka

Department of Medical Oncology, Institute of OncologyLjubljana, Slovenia
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Cavka, Luka
 and 
Tanja Cufer

Tanja Cufer

Department of Medical Oncology, University Clinic GolnikGolnik, Slovenia
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Cufer, Tanja
  
Sep 14, 2017
PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung's Cover Image
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Article Category: Research Article
Published Online: Sep 14, 2017
Page range: 357 - 362
Received: Apr 27, 2017
Accepted: Aug 09, 2017
DOI: https://doi.org/10.1515/raon-2017-0037
Keywords
© 2017 Urska Janzic, Izidor Kern, Andrej Janzic, Luka Cavka, Tanja Cufer
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

PD-L1 expression in NSCLC. Positive membranous reaction in tumor cells in adenocarcinoma (A), and squamous-cell carcinoma (B), positive cytoplasmic reaction in immune cells (C), negative reaction in adenocarcinoma (D).
PD-L1 expression in NSCLC. Positive membranous reaction in tumor cells in adenocarcinoma (A), and squamous-cell carcinoma (B), positive cytoplasmic reaction in immune cells (C), negative reaction in adenocarcinoma (D).

Figure 2

Proportions of PD-L1 positive samples of adenocarcinoma and squamous-cell carcinoma in tumor cells (TC) and i mmune cells (IC) at pre-defined cut-off values (≥ 5% and ≥ 10%) with corresponding p values.
Proportions of PD-L1 positive samples of adenocarcinoma and squamous-cell carcinoma in tumor cells (TC) and i mmune cells (IC) at pre-defined cut-off values (≥ 5% and ≥ 10%) with corresponding p values.

Clinicopathological patient characteristics

Total N = 54
Histology
     Squamous-cell carcinoma 25 (46%)
     Adenocarcinoma 29 (54%)
Sex
     Male 34 (63%)
     Female 20 (37%)
Age (years)
     Mean (SD) 62.4 (8.6)
Smoking status
     Current smoker 25 (46%)
     Former-smoker (>1 year) 21 (39%)
     Non-smoker 0 (0%)
     Unknown 8 (15%)

PD-L1 positivity according to histology for cut-off value of 5% and higher and 10% and higher

Tumor specimens N

 PD-L1 positivity (cut-off ≥ 5%) PD-L1 positivity (cut-off ≥ 10%)
TC or IC TC IC p value TC or IC TC IC p value
N (%) N (%) N (%) TC vs. IC N (%) N (%) N (%) TC vs. IC
Total 54 43 (80) 18 (33) 40 (74) 31 (57) 17 (31) 28 (52)
Adenocarcinoma 29 21 (72) 5 (17) 21 (72) < 0.001 12 (41) 4 (14) 12 (41) 0.008
Squamous-cell carcinoma 25 22 (88) 13 (52) 19 (76) 0.146 19 (76) 13 (52) 16 (64) 0.508
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English
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Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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