<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2017-0016_s_101_w2aab3b8c53b1b7b1aab1c16b1Aa"><h3>Background</h3><p>We aimed to analyse the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME)in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination.</p></sec><sec id="j_raon-2017-0016_s_102_w2aab3b8c53b1b7b1aab1c16b2Aa"><h3>Patients and methods</h3><p>Forty-six patients with histologically proven fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon. Prior to DCE-MRI examination, a unilateral breast lesion suspicious of malignancy was detected clinically, on mammography or breast ultrasonography.</p></sec><sec id="j_raon-2017-0016_s_103_w2aab3b8c53b1b7b1aab1c16b3Aa"><h3>Results</h3><p>The predominant features of FCCs presenting as NME in DCE-MRI examination were: unilateral regional or diffuse distribution (in 35 patients or 76.1%), heterogeneous or clumped internal pattern of enhancement (in 36 patients or 78.3%), plateau time-intensity curve (in 25 patients or 54.3%), moderate or fast wash-in (in 31 patients or 67.4%).Nonproliferative lesions were found in 11 patients (24%), proliferative lesions without atypia in 29 patients (63%) and lesions with atypia in six patients (13%), without statistically significant difference of morphokinetic features, except of the association of clustered microcysts with proliferative dysplasia without atypia.</p></sec><sec id="j_raon-2017-0016_s_104_w2aab3b8c53b1b7b1aab1c16b4Aa"><h3>Conclusions</h3><p>FCCs presenting as NME in DCE-MRI examination have several morphokinetic features suspicious of malignancy, therefore requiring biopsy (BI-RADS 4). Nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia predominantly share the same predefined DCE-MRI morphokinetic features.</p></sec></abstract>

BackgroundWe aimed to analyse the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME)in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination.Patients and methodsForty-six patients with histologically proven fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon. Prior to DCE-MRI examination, a unilateral breast lesion suspicious of malignancy was detected clinically, on mammography or breast ultrasonography.ResultsThe predominant features of FCCs presenting as NME in DCE-MRI examination were: unilateral regional or diffuse distribution (in 35 patients or 76.1%), heterogeneous or clumped internal pattern of enhancement (in 36 patients or 78.3%), plateau time-intensity curve (in 25 patients or 54.3%), moderate or fast wash-in (in 31 patients or 67.4%).Nonproliferative lesions were found in 11 patients (24%), proliferative lesions without atypia in 29 patients (63%) and lesions with atypia in six patients (13%), without statistically significant difference of morphokinetic features, except of the association of clustered microcysts with proliferative dysplasia without atypia.ConclusionsFCCs presenting as NME in DCE-MRI examination have several morphokinetic features suspicious of malignancy, therefore requiring biopsy (BI-RADS 4). Nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia predominantly share the same predefined DCE-MRI morphokinetic features.

Breast dynamic contrast enhanced MRI: fibrocystic changes presenting as a non-mass enhancement mimicking malignancy

Radiology and Oncology

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

BackgroundWe aimed to analyse the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and...

Breast dynamic contrast enhanced MRI: fibrocystic changes presenting as a non-mass enhancement mimicking malignancy

Article Category: Research Articles

Published Online: May 07, 2017

Page range: 130 - 136

Received: Oct 18, 2016

Accepted: Feb 20, 2017

DOI: https://doi.org/10.1515/raon-2017-0016

Keywords
breast, magnetic resonance imaging, fibrocystic changes

© 2017 Zorica C. Milosevic, Mirjan M. Nadrljanski, Zorka M. Milovanovic, Nina Z. Gusic, Slavko S. Vucicevic, Olga S. Radulovic

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Breast dynamic contrast enhanced MRI: fibrocystic changes presenting as a non-mass enhancement mimicking malignancy

Article Category: Research Articles

Published Online: May 07, 2017

Page range: 130 - 136

Received: Oct 18, 2016

Accepted: Feb 20, 2017

DOI: https://doi.org/10.1515/raon-2017-0016

Keywordsbreast, magnetic resonance imaging, fibrocystic changes

© 2017 Zorica C. Milosevic, Mirjan M. Nadrljanski, Zorka M. Milovanovic, Nina Z. Gusic, Slavko S. Vucicevic, Olga S. Radulovic

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords
breast, magnetic resonance imaging, fibrocystic changes