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Electrochemotherapy with bleomycin is effective in BRAF mutated melanoma cells and interacts with BRAF inhibitors

Dolinsek, Tanja

,

,

,

Potocnik, Tjasa

and

Jul 19, 2016

Electrochemotherapy with bleomycin is effective in BRAF mutated melanoma cells and interacts with BRAF inhibitors's Cover Image

Radiology and Oncology

Volume 50 (2016): Issue 3 (September 2016)

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Article Category: Research Article

Published Online: Jul 19, 2016

Page range: 274 - 279

Received: May 23, 2016

Accepted: Jun 14, 2016

DOI: https://doi.org/10.1515/raon-2016-0042

Keywords
electrochemotherapy, BRAF inhibitors, vemurafenib, melanoma

© 2016 Fazekas and Porvázsnyik, published by De Gruyter Open

This content is free.

Survival of melanoma cells after vemurafenib (VMF) treatment. Survival of (A) BRAF V600E mutated melanoma cells SK-MEL-28 and (B) non-mutated melanoma cells CHL-1.

Survival of BRAF V600E mutated SK-MEL-28 melanoma cells and non-mutated CHL-1 cells after ECT with bleomycin. BLM (bleomycin); BLM + EP (ECT with bleomycin). Dotted line represents the IC90 value.

Survival of BRAF V600E mutated SK-MEL-28 melanoma cells after concomitant treatment with ECT and vemurafenib. BLM (bleomycin); BLM + VMF (bleomycin and 0.5 pM vemurafenib); BLM + EP (ECT with bleomycin); BLM + EP + VMF (ECT with bleomycin and 0.5 pM vemurafenib). Dotted line represents the IC90 value.

Language:: English

Publication timeframe:: 4 times per year
Journal Subjects:: Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology

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