Prognostic factors | Died (n = 38) | Survived (n = 31) | p-value | |
---|---|---|---|---|
Age (years) | >65 | 17 | 11 | 0.44 |
≤ 65 | 21 | 20 | ||
Cancer type | Lymphoma | 29 | 23 | 0.84 |
Solid tumors | 9 | 8 | ||
CCI | Low (0) | 17 | 11 | 0.44 |
Medium - very high | 21 | 20 | ||
(≥1) | ||||
ACE-27 | None - mild (G0-1) | 20 | 13 | 0.38 |
Moderate - severe | 18 | 18 | ||
(G2-3) | ||||
G-CSF prophylactic | Yes | 14 | 7 | 0.2 |
No | 24 | 24 | ||
G-CSF therapeutic | Yes | 12 | 7 | 0.41 |
No | 26 | 24 | ||
Fever status | Febrile | 31 | 29 | 0.17 |
Afebrile | 7 | 2 | ||
MASCC score | < 15 | 25 | 10 | 0.006 |
≥ 15 | 13 | 21 | ||
Bloodstream infection | Yes | 15 | 10 | 0.54 |
No | 23 | 21 | ||
Mechanical ventilation | Yes | 26 | 4 | P < 0.001 |
No | 12 | 27 | ||
Lactic acidosisa | Yes | 7 | 0 | 0.04 |
No | 31 | 27 | ||
Time period of ICU admission (year) | 2000–2003 | 4 | 4 | 1.0 |
2004–2011 | 34 | 27 |
Characteristics | N (%) (n = 69) | |
---|---|---|
Median age (range) | Elderly (> 65 years) | 58 years (31–86) 28 (40.6%) |
Sex | Male | 42 (60.9%) |
Female | 27 (39.1%) | |
Cancer type | Lymphoma | 52 (75.4%) |
Solid tumors | 17 (24.6%) | |
Chemotherapy treatment intent | Neo/adjuvant solid or 1st-line lymphoma | 35 (50.7%) |
1st-line solid or 1st-relaps lymphoma | 13 (18.8%) | |
2nd-line solid or 2nd-relaps lymphoma | 12 (17.4%) | |
≥ 3rd-line solid or ≥ 3rd-relaps lymphoma | 9 (13.1%) | |
CCI | Low (0) | 28 (40.6%) |
Medium (1–2) | 30 (43.5%) | |
High (3–4) | 8 (11.6%) | |
Very high (≥ 5) | 3 (4.3%) | |
ACE-27 | None (G0) | 17 (24.6%) |
Mild (G1) | 16 (23.2%) | |
Moderate (G2) | 13 (18.9%) | |
Severe (G3) | 23(33.3%) | |
WHO performance status | 0–2 | 54 (78.3%) |
3–4 | 15 (21.7%) | |
Bone marrow infiltration | Yes | 22 (31.9%) |
No | 29 (42.0 %) | |
Unknown | 18 (26.1%) | |
Previous neutropenic infection | Yes | 24 (34.8%) |
No | 45 (65.2%) | |
Site of infection Includes 53 episodes of microbiologically documented infection (MDI) and 16 episodes of clinically documented infection (CDI) | Bloodstream | 25 (36.2%) |
Lower respiratory tract Pneumonias with 13 cases of MDI and 12 cases of CDI with radiological signs only | 25 (36.2%) | |
Gastrointestinal tract Includes cases of cholecystitis, peritonitis, neutropenic enterocolitis | 13 (18.8%) | |
Upper respiratory tract | 2 (2.9%) | |
Urinary tract | 1 (1.5%) | |
Skin and soft tissue | 1 (1.5%) | |
Unexplained fever CDI with fever and signs of septic shock | 2 (2.9%) | |
Time period of ICU admission (year) | 2000–2003 | 8 (13.6%) |
2004–2011 | 51 (86.4%) |
Characteristics | Afebrile (n = 9) | Febrile (n = 60) | p-value | |
---|---|---|---|---|
Age (years) | < 65 | 4 | 24 | 1.0 |
≤ 65 | 5 | 36 | ||
Sex | Male | 4 | 38 | 0.28 |
Female | 5 | 22 | ||
Cancer type | Lymphoma | 3 | 49 | 0.005 |
Solid tumors | 6 | 11 | ||
CCI | Low (0) | 5 | 23 | 0.47 |
Medium - very high (≥ 1) | 4 | 37 | ||
ACE-27 | None - mild (G0–1) | 5 | 28 | 0.73 |
Moderate - severe (G2–3) | 4 | 32 | ||
Status at diagnosis | Inpatient | 3 | 34 | 0.29 |
Outpatient | 6 | 26 | ||
MASCC score | < 15 | 5 | 30 | 1.0 |
≥ 15 | 4 | 30 | ||
Severe neutropenia | Yes | 3 | 27 | 0.72 |
No | 6 | 33 | ||
Type of infection | MDI | 8 | 45 | 0.33 |
CDI | 1 | 15 | ||
Bloodstream infection n = 25 | Gram negative also includes polymicrobial bacteremias with at least one Gram negative bacteria | 4 | 16 | 0.55 |
non-Gram negative | 0 | 5 | ||
Mean time to the ICU (hours) | 41 | 54 | 0.73 |