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Cerebral toxoplasmosis in a diffuse large B cell lymphoma patient

Lina Savsek

Lina Savsek

Department of Neurology, General Hospital CeljeCelje, Slovenia
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Savsek, Lina
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Tanja Ros Opaskar

Tanja Ros Opaskar

Unit of Neurology, Institute of Oncology LjubljanaLjubljana, Slovenia
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Opaskar, Tanja Ros
  
Feb 16, 2016
Cerebral toxoplasmosis in a diffuse large B cell lymphoma patient's Cover Image
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Article Category: Case Report
Published Online: Feb 16, 2016
Page range: 87 - 93
Received: May 27, 2014
Accepted: Aug 21, 2014
DOI: https://doi.org/10.1515/raon-2014-0042
Keywords
© 2016 Radiol Oncol
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1.

(A) MRI at time of diagnosis demonstrating multiple T2 and (B) fluid attenuated inversion recovery (FLAIR) hyperintense parenchymal lesions, located in both cerebral and cerebellar hemispheres, with mild surrounding edema. (C) On T1 sequences, these lesions were hypointense. (D) After contrast administration, only moderate rim enhancement was seen.
(A) MRI at time of diagnosis demonstrating multiple T2 and (B) fluid attenuated inversion recovery (FLAIR) hyperintense parenchymal lesions, located in both cerebral and cerebellar hemispheres, with mild surrounding edema. (C) On T1 sequences, these lesions were hypointense. (D) After contrast administration, only moderate rim enhancement was seen.

Figure 2.

Full body 18F-FDG PET/CT revealing focal hypometabolism, corresponding to toxoplasma lesions. The largest lesion is seen in the right occipital lobe.
Full body 18F-FDG PET/CT revealing focal hypometabolism, corresponding to toxoplasma lesions. The largest lesion is seen in the right occipital lobe.

Figure 3.

Lesion size and edema reduction after 6 weeks of intensive antibiotic therapy, as demonstrated by (A) fluid attenuated inversion recovery (FLAIR) and (B) T1 sequence.
Lesion size and edema reduction after 6 weeks of intensive antibiotic therapy, as demonstrated by (A) fluid attenuated inversion recovery (FLAIR) and (B) T1 sequence.

Figure 4.

Follow-up MRI after 4 months reveals further reduction of lesion size. (A) T1 sequence + gadolinium, (B) T2 sequence.
Follow-up MRI after 4 months reveals further reduction of lesion size. (A) T1 sequence + gadolinium, (B) T2 sequence.
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