<abstract xmlns="http://www.w3.org/1999/xhtml">Aim: In the current study, some imaging characteristics of AuNPs were quantitatively analyzed and compared with two conventional contrast media (CM) including Iodine and Gadolinium by using of a cylindrical phantom.Methods: AuNPs were synthesized with the mean diameter of 16 nm and were equalized to the concentration of 0.5, 1, 2 and 4 mg/mL in the same volumes. A cylindrical phantom resembling the head and neck was fabricated and drilled to contain small tubes filled with Iodine, Gadolinium, and AuNPs as contrast media. The phantom was scanned in different exposure techniques and CT numbers of three studied contrast media inside test tubes were measured in terms of Hounsfield Unit (HU). The imaging parameters of the noise and contrast to noise ratios (CNR) were calculated for all studied CMs.Results: AuNPs showed 128% and 166% higher CT number in comparison with Iodine and Gadolinium respectively. Also, Iodine had a greater CT number than Gadolinium for the same exposure techniques and concentration. The maximum CT number for AuNPs and studied contrast materials was obtained at the highest mAs and the lowest tube potential. The maximum CT number were 1033±11 (HU) for AuNP, 565±10 (HU) for Iodine, 458±11 for Gadolinium. Moreover, the maximum CNRs of 433±117, 203±53, 145±37 were found for AuNPs, Iodine and Gadolinium respectively.Conclusion: The contrast agent based on AuNPs showed higher imaging quality in terms of contrast and noise relative to other iodine and gadolinium based contrast media in X-ray computed tomography. Application of the AuNPs as a contrast medium in x-ray CT is recommended.</abstract>

Aim: In the current study, some imaging characteristics of AuNPs were quantitatively analyzed and compared with two conventional contrast media (CM) including Iodine and Gadolinium by using of a cylindrical phantom.Methods: AuNPs were synthesized with the mean diameter of 16 nm and were equalized to the concentration of 0.5, 1, 2 and 4 mg/mL in the same volumes. A cylindrical phantom resembling the head and neck was fabricated and drilled to contain small tubes filled with Iodine, Gadolinium, and AuNPs as contrast media. The phantom was scanned in different exposure techniques and CT numbers of three studied contrast media inside test tubes were measured in terms of Hounsfield Unit (HU). The imaging parameters of the noise and contrast to noise ratios (CNR) were calculated for all studied CMs.Results: AuNPs showed 128% and 166% higher CT number in comparison with Iodine and Gadolinium respectively. Also, Iodine had a greater CT number than Gadolinium for the same exposure techniques and concentration. The maximum CT number for AuNPs and studied contrast materials was obtained at the highest mAs and the lowest tube potential. The maximum CT number were 1033±11 (HU) for AuNP, 565±10 (HU) for Iodine, 458±11 for Gadolinium. Moreover, the maximum CNRs of 433±117, 203±53, 145±37 were found for AuNPs, Iodine and Gadolinium respectively.Conclusion: The contrast agent based on AuNPs showed higher imaging quality in terms of contrast and noise relative to other iodine and gadolinium based contrast media in X-ray computed tomography. Application of the AuNPs as a contrast medium in x-ray CT is recommended.

A study on the imaging characteristics of Gold nanoparticles as a contrast agent in X-ray computed tomography

Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz,

Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz,

Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences,

Department of Radiology, Shohada Hospital, Tabriz University of Medical Sciences, Tabriz,

Radiology Department, Paramedical School, Tabriz University of Medical Sciences, Tabriz,

Polish Journal of Medical Physics and Engineering

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Aim: In the current study, some imaging characteristics of AuNPs were quantitatively analyzed and compared with two conventional contrast media (CM) including...

A study on the imaging characteristics of Gold nanoparticles as a contrast agent in X-ray computed tomography

Published Online: Mar 30, 2017

Page range: 9 - 14

Received: Sep 16, 2016

Accepted: Jan 03, 2017

DOI: https://doi.org/10.1515/pjmpe-2017-0003

Keywords
AuNP, contrast media, X-ray computed tomography, nanoparticle

© 2017 Polish Society of Medical Physics

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A study on the imaging characteristics of Gold nanoparticles as a contrast agent in X-ray computed tomography

Published Online: Mar 30, 2017

Page range: 9 - 14

Received: Sep 16, 2016

Accepted: Jan 03, 2017

DOI: https://doi.org/10.1515/pjmpe-2017-0003

KeywordsAuNP, contrast media, X-ray computed tomography, nanoparticle

© 2017 Polish Society of Medical Physics

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
AuNP, contrast media, X-ray computed tomography, nanoparticle