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Cyanobacterial and microalgal bioactive compounds – the role of secondary metabolites in allelopathic interactions

Adam Żak

Adam Żak

Institute of Oceanology Polish Academy of Sciences, Marine Chemistry and Biochemistry DepartmentSopot, Poland
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Żak, Adam
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Alicja Kosakowska

Alicja Kosakowska

Institute of Oceanology Polish Academy of Sciences, Marine Chemistry and Biochemistry DepartmentSopot, Poland
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Kosakowska, Alicja
  
Mar 10, 2016
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Article Category: Review paper
Published Online: Mar 10, 2016
Page range: 131 - 143
Received: Jun 09, 2015
Accepted: Jul 27, 2015
DOI: https://doi.org/10.1515/ohs-2016-0013
Keywords
© Faculty of Oceanography and Geography, University of Gdañsk, Poland. All rights reserved.
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Bioactive properties of selected cyanobacterial compounds

Species Compound Activity Target References
Dichotrix baueriana Bauerines A-C antiviral HSV-2 (Herpes Simplex Virus) Larsen et al. (1994)
Microcystis ichtyoblabe Ichtyopeptin A, B antiviral Influenza A virus Zainuddin et al. (2007)
Nostoc ellipsosporum Cyanovirin-N antiviral HIV-1 (Human Immunodeficiency Virus) Boyd et al. (1997) Dey et al. (2000)
Scytonema varium Scytovirin antiviral HIV-1 Bokesh et al. (2003)
Spirulina platensis Calcium spirulan antiviral HSV-1, HIV-1, Maesles virus, Mumps virus, Influenza virus, Polio virus, Coxsackie virus Hayashi et al. (1996)
Anabaena minutissima Minutissamide A,D cytotoxic (anticancer) HT-29 (Human colon cancer cell line) Kang et al. (2011)
Calothrix sp. Calothrixin A cytotoxic (anticancer) Human T-lymphocyte cell line (Jurkat) Chen et al. (2003)
Lyngbya majuscula Homodolastatin 16 cytotoxic (anticancer) Oesophageal and cervical cancer cell lines Davies-Coleman et al. (2003)
Lyngbya sp. Curacin A cytotoxic (anticancer) MCF-7 (Breast Cancer Cells) Verdier-Pinard et al. (1998)
Microcystis aeruginosa Aeruginoguanidine 98-A, 98C cytotoxic (anticancer) P388 leukemia cell line Ishida et al. (2002)
Moorea producens Apratoxin H, Apratoxin A sulfoxide cytotoxic (anticancer) NCI-H460 (Human lung cancer cells) Thornburg et al. (2013)
Nostoc commune Comnostin B cytotoxic (anticancer) KB ( cervical adenocarcinoma cells) and Caco-2 (heterogeneous human epithelial colorectal adenocarcinoma cells) Jaki et al. (2000)
Nostoc sp Cryptophycin 8 cytotoxic (anticancer) TSU-prostate, LNCaP-prostate, H116-colon, MX-1 breast, cell lines Liang et al. (2005)
Symploca sp. Symplostatin 3 cytotoxic (anticancer) Human Tumor Cell Lines Luesch et al. (2002)

Selected identified bioactive compounds produced by cyanobacteria and microalgae and their allelopathic influence on target organisms

Group/species Compound Target organism Mode of action Effect References
Cyanobacteria
Nostoc insulare 4,4’-dihydroxybiphenyl cyanobacteria unknown growth inhibition Volk (2005) Volk and Furket (2006)
Nostoc linckia cyanobacterin LU-1 (phenolic compound) phytoplankton unknown growth inhibition, photosynthesis inhibition, oxygen evolution Gromov et al. 1991
Nostoc spongiaeforme nostocine A phytoplankton formation of ROS growth inhibition Hirata et al. (2003)
Nostoc spp . LMW bacteriocin phytoplankton unknown cell death Flores and Wolk (1986)
nostocyclamid phytoplankton unknown growth inhibition Jüttner et al. (2001)
Scytonema hofmanni cyanobacterin microalgae unknown photosynthesis inhibition at PSII, cell death Mason et al. (1982) Gleason and Paulson (1984) Abarzua et al. (1999)
Microalgae
Chlorella vulgaris chlorellin phytoplankton unknown growth retardant (autoinhibition) Pratt and Fong (1940) cited in Legrand et al. (2003)
Coolia monotis cooliatoxin phytoplankton membrane damage photosynthesis inhibition, lysis Donner et al. (2000)
Haslea ostrearia marennin microalgae unknown growth inhibition Pouvreau et al. (2007)
Karenia mikimotoi gymnodimine phytoplankton membrane damage lysis, cell death Yasumoto et al. (1990) Uchida et al. (1995)
Prorocentrum lima okadaic acid phytoplankton modify physiological function growth inhibition, protein phosphatase inhibition Sugg and Dolah (1999)
Prymnesium parvum prymnesin phytoplankton membrane damage lysis, cell death Igarashi et al. (1998) Fistarol et al. (2003)
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Chemistry, Chemistry, other, Geosciences, Geosciences, other, Life Sciences, Life Sciences, other
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