The interaction between science and policy is affected by increasingly dissolving boundaries whereby a number of issues arise, such as, what should political advice for national parliaments consist of in the face of global socio-technical developments? The Internet of Things in relation to Big Data resulting in enormously fast analysis of huge amounts of data, accelerates the dissolution of boundaries between science, society and policy at global level. This type of “globalization” raises questions that concern very diverse and intimate areas of life, ranging from food to health to work automation. How can access to science and technology in very different societal settings can be enabled, while also accounting for global developments? The article deals with the assumption that global effects of science and technology as well as global challenges lead to an urgent need to develop methodologies for analyzing and also shaping these developments. Under the umbrella term “Global Technology Assessment” (Global TA) it is argued that the problem-oriented, interdisciplinary methodology of technology assessment offers a promising frame to deal with cultural and ethical questions in relation to emerging technologies. This framework is needed in order to be able to develop meaningful national comparisons, but also in order to be able to approach the analysis of common future challenges on equal footing.