<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Since fluoroquinolones are one of the most commonly used antibacterial drugs in aquaculture, there is a risk of their residues to be found in the treated fish. The objective of this study was to examine the changes in enrofloxacin and ciprofloxacin levels during storage of rainbow trout and common carp muscle at −18 °C. The trout and carp were treated orally with a single dose of 10 mg/kg of enrofloxacin. Tissue samples were collected 24 h after the treatment and stored at −18 °C for 270 days either as a whole fish or as precut muscle samples. Results for trout revealed that in the precut samples enrofloxacin concentration decreased significantly only after 9 months of storage, whereas a significant decline in the ciprofloxacin level was observed much earlier (after 3 months). After 9 months of storage, the trout stored without being sliced and eviscerated showed significantly higher levels of both quinolones as compared to the precut muscle samples. The enrofloxacin levels in the carp musculature decreased considerably after 3 months of storage and stayed almost unchanged up to the end of the study, whereas the ciprofloxacin concentration continued to drop even after this period and after 270 days constituted 1/6 of the initial values.</p></abstract>

Since fluoroquinolones are one of the most commonly used antibacterial drugs in aquaculture, there is a risk of their residues to be found in the treated fish. The objective of this study was to examine the changes in enrofloxacin and ciprofloxacin levels during storage of rainbow trout and common carp muscle at −18 °C. The trout and carp were treated orally with a single dose of 10 mg/kg of enrofloxacin. Tissue samples were collected 24 h after the treatment and stored at −18 °C for 270 days either as a whole fish or as precut muscle samples. Results for trout revealed that in the precut samples enrofloxacin concentration decreased significantly only after 9 months of storage, whereas a significant decline in the ciprofloxacin level was observed much earlier (after 3 months). After 9 months of storage, the trout stored without being sliced and eviscerated showed significantly higher levels of both quinolones as compared to the precut muscle samples. The enrofloxacin levels in the carp musculature decreased considerably after 3 months of storage and stayed almost unchanged up to the end of the study, whereas the ciprofloxacin concentration continued to drop even after this period and after 270 days constituted 1/6 of the initial values.

Effect of Storage on Residue Levels of Enrofloxacin in Muscle of Rainbow Trout (<italic>Oncorhynchus mykiss</italic>) and Common Carp (<italic>Cyprinus carpio</italic>)

Department of Hygiene and Technology of Foods, Faculty of Veterinary Medicine

Department of Pharmacology, Physiology of Animals and Physiological Chemistry, Faculty of Veterinary Medicine

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of Storage on Residue Levels of Enrofloxacin in Muscle of Rainbow Trout () and Common Carp ()

Since fluoroquinolones are one of the most commonly used antibacterial drugs in aquaculture, there is a risk of their residues to be found in the treated fish....

Effect of Storage on Residue Levels of Enrofloxacin in Muscle of Rainbow Trout (Oncorhynchus mykiss) and Common Carp (Cyprinus carpio)

Published Online: Mar 15, 2016

Page range: 97 - 102

Received: Sep 23, 2015

Accepted: Jan 25, 2016

DOI: https://doi.org/10.1515/macvetrev-2016-0076

Keywords
ciprofloxacin, common carp, enrofloxacin, rainbow trout, residues, storage

© 2016 Ralica Kyuchukova et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of Storage on Residue Levels of Enrofloxacin in Muscle of Rainbow Trout (Oncorhynchus mykiss) and Common Carp (Cyprinus carpio)

Published Online: Mar 15, 2016

Page range: 97 - 102

Received: Sep 23, 2015

Accepted: Jan 25, 2016

DOI: https://doi.org/10.1515/macvetrev-2016-0076

Keywordsciprofloxacin, common carp, enrofloxacin, rainbow trout, residues, storage

© 2016 Ralica Kyuchukova et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
ciprofloxacin, common carp, enrofloxacin, rainbow trout, residues, storage