Two (Sulfone-Amidosulphonyl)-Amides Derived from N-(P-Amidobenzoyl)-L-Glutamine; Optimized Synthesis and Toxicity Study

Two derivatives of glutamine were synthesized and the most convenient physical conditions for obtaining reactions were established in factorial experiments with temperature and time of reactions considered as relevant variables. A quantum-mechanical characterization for the new compounds was performed by using HyperChem 8.0.6 Programs and their physical and chemical properties were theoretically estimated. The toxicity of two new compounds was experimentally determined.