Using Machine Reading to Understand Alzheimer’s and Related Diseases from the Literature
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Dec 29, 2017
About this article
Article Category: Research Paper
Published Online: Dec 29, 2017
Page range: 81 - 94
Received: Oct 16, 2017
Accepted: Nov 12, 2017
DOI: https://doi.org/10.1515/jdis-2017-0021
Keywords
© 2017 Walter de Gruyter GmbH, Berlin/Boston
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
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What are CJS, MRI, APP, and APOE?
| Term | Definition |
|---|---|
| AD | a neurodegenerative disorder |
| AD | a genetically complex and heterogeneous disorder |
| CJS | a rare neurodegenerative disease |
| CJS | a fatal neurodegenerative illness |
| CJS | an incurable disease |
| MRI | a useful diagnostic marker |
| MRI | a promising AD biomarker |
| MRI | the most widely used and less invasive medical imaging technique |
| APP | a transmembrane glycoprotein |
| APP | an extremely complex molecule |
| APP | |
| APOE | the major apolipoprotein |
| APOE | |
| APOE | the most prevalent and best established genetic risk factor for late-onset AD. |
Gene LDA results ranked by popularity_
| Year | 1st topic | 2nd topic | 3rd topic | 4th topic | 5th topic |
|---|---|---|---|---|---|
| All | INS | MS | MAPT | ||
| (1945–2015) | TNF | BCHE | PRNP | SDS | |
| BDNF | CAT | PSEN1 | GFAP | SST | |
| BACE1 | CA3 | CA1 | ALB | GRN | |
| NGF | CA1 | MDD1 | PSD | ||
| 1995–2004 | PRNP | TNF | |||
| MS | BDNF | INS | PSEN1 | CA1 | |
| CD4 | ACT | NGF | GFAP | SDS | |
| SPY | A2M | TF | MAPT | ALB | |
| PSEN1 | LDLR | TTR | BCHE | CA3 | |
| 2005–2014 | MS | PSEN1 | |||
| INS | GFAP | PRNP | BDNF | ||
| TNF | CD4 | CA1 | MAPT | ||
| CAT | BACE1 | BCHE | ALB | ||
| ACE | NOTCH3 | NGF | SYP | PSEN2 |
MeSH LDA results ranked by popularity_
| Year | 1st topic | 2nd topic | 3rd topic | 4th topic | 5th topic |
|---|---|---|---|---|---|
| All | Huntington disease | Mental disorders | Tau proteins | Aging | Creutzfeldt-Jakob syndrome |
| (1945–2015) | Parkinson disease | Caregivers | Amyloid beta-protein precursor | Cognition | Apolipoproteins E |
| Neurons | Dementia, vascular | Neurodegenerative diseases | Cholinesterase inhibitors | Magnetic resonance imaging | |
| Cerebral coretex | AIDS dementia complex | Brain diseases | Memory disorders | Nursing homes | |
| Nerve tissue proteins | Schizophrenia | Amyloid | Neuropsychological tests | Genetic predisposition to disease | |
| 1995–2004 | Creutzfeldt-Jakob syndrome | Amyloid beta-protein precursor | Parkinson disease | Cholinesterase inhibitors | AIDS dementia complex |
| Apolipoproteins E | Neurons | Caregivers | Dementia, vascular | Aging | |
| Huntington disease | Membrane proteins | Neuropsychological tests | Memory disorders | Peptide fragments | |
| Tau proteins | Nerve tissue proteins | Cognition | Nootropic agents | HIV-1 | |
| Magnetic resonance imaging | Neurodegenerative diseases | Memory | Schizophrenia | HIV infections | |
| 2005–2014 | Neurons | Aging | Cognition | Parkinson disease | Cholinesterase inhibitors |
| Peptide fragments | Neuropsychological tests | Neurodegenerative diseases | Caregivers | Neuroprotective agents | |
| Tau proteins | Magnetic resonance imaging | Mental disorders | Amyloid | Dementia, vascular | |
| Amyloid beta-protein precursor | Memory disorders | Nursing homes | Creutzfeldt-Jakob syndrome | Frontotemporal dementia | |
| Huntington disease | Memory | Amyotrophic lateral sclerosis | Depression | Amyloid precursor protein secretases |
Question answering example: What is Huntington’s disease?
| Question | Answer example |
|---|---|
| What is Huntington’s disease? | an inherited neurodegenerative disorder (44) |
| a neurodegenerative disorder (28) | |
| a hereditary brain disease (2) | |
| an incurable genetic neurodegenerative disorder (1) | |
| a complex, single gene (1) |