<abstract xmlns="http://www.w3.org/1999/xhtml">Critically ill patients usually present with circulatory hypoxemia and this is associated with a poorer prognosis. The aim of this experimental study was to examine the effect of U-74389G with specific regard to a hypoxemia/re-oxygenation protocol, on mean blood haemoglobin (Hgb) levels in rats.<bold>Materials and methods</bold>: Forty rats (mean weight 231.9 g) were used in the study. Hgb levels were measured at sixty minutes (groups A and C) and at 120 minutes (groups B and D) of re-oxygenation. U-74389G was administered only in groups C and D.<bold>Results</bold>: U-74389G administration non-significantly increased the Hgb levels by 3.95+2.10% (p=0.0604). Re-oxygenation time non-significantly increased the Hgb levels by 3.39+2.12% (p=0.1285). U-74389G administration and reoxygenation time together, significantly increased the Hgb levels by 2.55%+1.25% (p=0.0423).<bold>Conclusions</bold>: Results of this study indicate that U-74389G administration, re-oxygenation time, but mainly their interaction significantly increase the Hgb levels within the studied time limits.</abstract>

Critically ill patients usually present with circulatory hypoxemia and this is associated with a poorer prognosis. The aim of this experimental study was to examine the effect of U-74389G with specific regard to a hypoxemia/re-oxygenation protocol, on mean blood haemoglobin (Hgb) levels in rats.Materials and methods: Forty rats (mean weight 231.9 g) were used in the study. Hgb levels were measured at sixty minutes (groups A and C) and at 120 minutes (groups B and D) of re-oxygenation. U-74389G was administered only in groups C and D.Results: U-74389G administration non-significantly increased the Hgb levels by 3.95+2.10% (p=0.0604). Re-oxygenation time non-significantly increased the Hgb levels by 3.39+2.12% (p=0.1285). U-74389G administration and reoxygenation time together, significantly increased the Hgb levels by 2.55%+1.25% (p=0.0423).Conclusions: Results of this study indicate that U-74389G administration, re-oxygenation time, but mainly their interaction significantly increase the Hgb levels within the studied time limits.

The Effect of the Antioxidant Drug “U-74389G” on Haemoglobin Levels Following a Hypoxemia/ Re-oxygenation Protocol in Rats

Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece

Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece

Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece

Experimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co.

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Critically ill patients usually present with circulatory hypoxemia and this is associated with a poorer prognosis. The aim of this experimental study was to...

The Effect of the Antioxidant Drug “U-74389G” on Haemoglobin Levels Following a Hypoxemia/ Re-oxygenation Protocol in Rats

Published Online: Aug 06, 2015

Page range: 102 - 106

Received: May 02, 2015

Accepted: Jul 05, 2015

DOI: https://doi.org/10.1515/jccm-2015-0017

Keywords
hypoxia, haemoglobin, U-74389G, re-oxygenation

© Constantinos Tsompos et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Effect of the Antioxidant Drug “U-74389G” on Haemoglobin Levels Following a Hypoxemia/ Re-oxygenation Protocol in Rats

Published Online: Aug 06, 2015

Page range: 102 - 106

Received: May 02, 2015

Accepted: Jul 05, 2015

DOI: https://doi.org/10.1515/jccm-2015-0017

Keywordshypoxia, haemoglobin, U-74389G, re-oxygenation

© Constantinos Tsompos et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
hypoxia, haemoglobin, U-74389G, re-oxygenation