1. bookVolume 10 (2017): Issue 2 (December 2017)
Journal Details
License
Format
Journal
First Published
08 Sep 2014
Publication timeframe
2 times per year
Languages
English
Journal Details
License
Format
Journal
First Published
08 Sep 2014
Publication timeframe
2 times per year
Languages
English

Affective disorders, including depression, are of great social importance and lead to serious everyday life infringement and disability. Affective disorders are one of the main causes of suicide causes. Anxiety disorders represent a variety of psychic disorders that often lead to disability. Anxiety and depression syndromes together are often seen in patients. Vitamin B12 (cobalamin) is the only vitamin containing cobalt. Our aim was to investigate, evaluate and compare depression and increased anxiety and serum Vitamin B12 level in patients with depression, in patients with Vitamin B12 deficiency anemia and healthy controls. We investigated 74 subjects – 38 patients and 36 healthy controls. Serum Vitamin B12 level was measured in all participants. It is assumed that normal ranges of Vitamin B12 level vary. The most recently accepted ones are 200 to 900 pg/ml. In cases of levels below 200 pg/ml, a therapy with vitamin B12 should be applied. On the other hand, the level necessary for normal biochemical processes is higher – 250 pg/ml. In our study, serum Vitamin B12 level in more than 50% of patients with depression/anxiety was below 200 pg/ml, and in more than 60% of these patients it was below 250 pg/ml.

Keywords

1. Kaplan HI, Sadock BJ. Kaplan. and Sadock‘s synopsis of psychiatry: behavioral sciences, clinical psychiatry. 11th ed. London:Wolters Kluwer;2015.Search in Google Scholar

2. Andersan NC, Black OW. Introductory textbook of psychiatry. 3rd ed. London: American psychiatric publishing. Inc; 2001.Search in Google Scholar

3. Milanova VK. [Psychiatry – book for medical student and medical specialists].1st ed. Sofia: Medicine and P.T;2013. Bulgarian.Search in Google Scholar

4. Akabaliev V. [Book for medical student]. 3rd ed. Plovdiv: Laks book; 2015. Bulgarian.Search in Google Scholar

5. Boncheva I. [Medical psychology – book for health care specialists]. Varna: Medical University;2012. Bulgarian.Search in Google Scholar

6. Madzhirova N. [Practical Guide of psychiatry for general medicine specialists]. Sofia: Rajkov; 2009. Bulgarian.Search in Google Scholar

7. Stoimenova M. [The suicide – an escape or a decision?] Sofia: Oita-M; 2014. Bulgarian.Search in Google Scholar

8. Todorov V, Ljutckanova E, Marinova I, Lyubomirova D, Tzvetkov N. [Internal diseases 2nd part - book for medical students]. 1st ed. Pleven: Medical University; 2012. Bulgarian.Search in Google Scholar

9. Morris AL, Thomas AB, Francis JK, Jerome L, Loren RM, Richard W. Megavitamin and orthomolecular therapy in psychiatry. Washington: American Psychiatric Association; 1973.Search in Google Scholar

10. Airola P. Hypoglycemia: A Better Approach. Phoenix, Ariz.: Health Plus Publishers; 1977.Search in Google Scholar

11. Miller C. Vitamin B12 for depression. Livestrong.com [Internet].c2017 [cited 2017 Sept] [about 1p.] Available from: https://www.livestrong.com/article/463325-vitamin-b12-for-depression/Search in Google Scholar

12. Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol. 2005;19(1):59-65.Search in Google Scholar

13. Methylcobalamininfo Info. Treating depression with vitamin B12. [Internet]. c2015 [cited 2017, Sept22]; [about 1 screen.] Available from: http://www.methylcobalamininfo.com/b12-depression-treatment/Search in Google Scholar

14. Barclay L. Vitamins B6, B12 may protect against depression in older adults. Medscape [Internet] 2010; [cited 2017 Sept 12]; [about 1 p.] Available from: https://www.medscape.com/viewarticle/724456.Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo