[Abere TA, Okoto PE, Agoreyo FO. (2010). Antidiarrhoea and toxicological evaluation of the leaf extract of Dissotis rotundifolia triana (Melastomataceae). BMC Compl and Alter Med 10: 71.10.1186/1472-6882-10-71]Search in Google Scholar
[Ajayi AO. (2008). Antimicrobial nature and use of some medicinal plants in Nigeria. Afr J Biotechnol 7(5): 595-599.]Search in Google Scholar
[Akuodor GC, Onyewenjo SC, Anyalewechi NA, Essien AD, Akpan JL, Okoroafor DO, Okere MO. (2011). In vitro antimicrobial activity of leaf extract of Berlina grandifl ora. Huth. and Dalz. Afr J Microbiol Res 5: 1358-1360.10.5897/AJMR10.692]Open DOISearch in Google Scholar
[Andrews JM. (2001). Determination of minimum inhibitory concentration. J Antimicrob Chemother 48: 5-16.10.1093/jac/48.suppl_1.5]Search in Google Scholar
[Aziz MA. (2015). Qualitative phytochemical screening and evaluation of antiinfl ammatory, analgesic and antipyretic activities of Microcos paniculata barks and fruits. J Integrative Medicine 13(3): 173-184.10.1016/S2095-4964(15)60179-0]Search in Google Scholar
[Brautbar N, Williams J II. (2002). Industrial solvents and liver toxicity: risk assessment, risk factors and Mechanisms. International J of Hygiene and Environmental Health 25(6): 497-492.10.1078/1438-4639-00175]Search in Google Scholar
[Corstiaen PC, Sosef SM. (2007). Revision of African genus Annickia. Syst Geogr Plants 77: 146-152.]Search in Google Scholar
[Dietrich L. (1983). A new approach to practical acute toxicity testing. Archives of toxicology 54: 275-287.10.1007/BF01234480]Search in Google Scholar
[Essien AD, Akuodor GC, Essien EA, Asika EC, Chilaka KC, Nwadum SK (2015). Evaluation of antipyretic potential of the ethanolic leaf extract of Salacia lehmbachii Loes. Asian J Med Sci 7(2): 22-25.10.19026/ajms.7.5175]Search in Google Scholar
[Essien AD, Essiet GA, Akuodor GC, Aja DO, Thomas EE (2016). Studies on gastrointestinal properties of ethanolic leaf extract in Wistar rats. Afr J Pharm Pharmacol 10(20): 451-457.10.5897/AJPP2016.4536]Search in Google Scholar
[Essien AD, Essiet GA, Akuodor GC, Nwobodo NN, AkpaN JL, Utsalo SJ (2017). Evaluation of antiplasmodial eff ects of the ethanolic leaf extract of Salacia lehmbachii on Plasmodium berghei infected mice. European J Biological Research 7(2): 124-130.]Search in Google Scholar
[Guyton AC, Hall JE. (2000). Texbook of Medical Physiology, W.B sauder, Philadelphia, PA, USA. Klein R. (1996). Toxicology and herbs. Aust Journal of Med Herhaliasm 8: 100-10.]Search in Google Scholar
[Kluwe WM. (1981). Renal function tests as indicators of kidney injury in subacute toxicity studies. Toxicology and Applied Pharmacology 57(3): 414-424.10.1016/0041-008X(81)90239-8]Open DOISearch in Google Scholar
[Kumar HNK, Preethi SD, Chandana E, Chauhan JB. (2012). Phytochemical Screening and antibacterial activity of Stachytarpheta indica. Int J Pharm Sci Res 3(6): 1684-1687.]Search in Google Scholar
[Lameire N, Van Biesen W, Vanholder R (2005).Acute renal failure. The Lancet 365(9457): 417-430.10.1016/S0140-6736(05)70238-5]Search in Google Scholar
[National Research Council (2006). Toxicity testing for assessing environmental agents, Interim Report, National Academies Press, Washington, DC, USA.]Search in Google Scholar
[Organisation for Economic Cooperation and Development (2002). Guidelines for the Testing of Chemicals/Section 4: Health Eff ects Test No. 423, Acute oral toxicity-acute toxic class method, Paris, OECD.]Search in Google Scholar
[Organisation for Economic Cooperation and Development (2008). OECD Guideline for Testing of Chemicals (TG 407). Repeated Dose 28-Day Oral Toxicity Study in Rodents. OECD/OEDC.]Search in Google Scholar
[Olorunnisola OS, Bradley G, Afolanya. (2012). Acute and sub-chronic toxicity studies of methanolic extract of Tulbaghia violacearhizomes in Wistar rats. Afr J Biotechnolo 11: 14934-14940.]Search in Google Scholar
[Oloyede OI (2005). Chemical profi le of unripe pulp of Carica papaya. Pak J Nutr 4: 379.10.3923/pjn.2005.379.381]Search in Google Scholar
[United States Department of Health and Human Services, Public Health Service, National Institutes of Health. (1985). Guide for the Care and Use of Laboratory Animals; NIH Publication No. 85-23; National Institutes of Health: Bethesda, MD, USA, 1985.]Search in Google Scholar
[Yakubu MT, Akanji MA, Oladiji AT. (2007). Haematological evaluation in male albino rats following chronic administration of aqueous extract of Fadoga agrestis stem. Pharmacognosy Magazine 3: 34-38.]Search in Google Scholar
[Wang L, Li Z, Li L, Li Y, Yu M, Zhou Y, Lv X, Arai H, Xu Y (2014). Acute and subchronic oral toxicity profi les of the aqueous extract of Cortex Dictamni in mice and rats. J Ethnopharmacol 158: 201-215.10.1016/j.jep.2014.10.02725456429]Search in Google Scholar
[WHO. (2005). National policy on traditional medicine and regulation of herbal medicines: Report of a WHO global survey. World Health Organization, Geneva, Switzerland.]Search in Google Scholar
[WHO. (2013). Regulatory situation of herbal medicines: a worldwide review. World Health Organization, Geneva, Switzerland.]Search in Google Scholar