<abstract xmlns="http://www.w3.org/1999/xhtml"><p>An <italic>in vivo</italic> study was carried out on the freshwater fish <italic>Barbonymus gonionotus</italic> to evaluate the genotoxic effects of the organophosphate quinalphos. The fish were exposed to sub-lethal doses of quinalphos (0%, 10%, 25%, and 50% of LC<sub>50</sub>) for a period of 30 days. Analysis of biochemical characteristics (protein and lipid contents of different organs), nuclear abnormalities of erythrocytes (NAE) and morphological abnormalities of erythrocytes (MAE) were performed on peripheral erythrocytes sampled at post-treatment intervals of 0 and 30 days. The biochemical results revealed a significant dose-dependent decline in protein and lipid contents and increase in the frequencies of NAE as well as MAE. Our findings also confirmed that the morphological deformations of erythrocytes in addition to NAE on fish erythrocytes <italic>in vivo</italic> are effective tools in determining the potential genotoxicity of organophosphates.</p></abstract>

An in vivo study was carried out on the freshwater fish Barbonymus gonionotus to evaluate the genotoxic effects of the organophosphate quinalphos. The fish were exposed to sub-lethal doses of quinalphos (0%, 10%, 25%, and 50% of LC50) for a period of 30 days. Analysis of biochemical characteristics (protein and lipid contents of different organs), nuclear abnormalities of erythrocytes (NAE) and morphological abnormalities of erythrocytes (MAE) were performed on peripheral erythrocytes sampled at post-treatment intervals of 0 and 30 days. The biochemical results revealed a significant dose-dependent decline in protein and lipid contents and increase in the frequencies of NAE as well as MAE. Our findings also confirmed that the morphological deformations of erythrocytes in addition to NAE on fish erythrocytes in vivo are effective tools in determining the potential genotoxicity of organophosphates.

Chronic exposure to quinalphos shows biochemical changes and genotoxicty in erythrocytes of silver barb, <italic>Barbonymus gonionotus</italic>

Department of Fisheries Biology & Genetics

Freshwater Station, Bangladesh Fisheries Research Institute (BFRI)

Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Chronic exposure to quinalphos shows biochemical changes and genotoxicty in erythrocytes of silver barb, 

An in vivo study was carried out on the freshwater fish Barbonymus gonionotus to evaluate the genotoxic effects of the organophosphate quinalphos. The fish...

Chronic exposure to quinalphos shows biochemical changes and genotoxicty in erythrocytes of silver barb, Barbonymus gonionotus

Published Online: Feb 14, 2018

Page range: 99 - 106

Received: Mar 28, 2017

Accepted: Oct 31, 2017

DOI: https://doi.org/10.1515/intox-2017-0016

Keywords
pesticides, organophosphate, erythrocytes, nuclear abnormalities, micronucleus test, genotoxicity

© 2017 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Chronic exposure to quinalphos shows biochemical changes and genotoxicty in erythrocytes of silver barb, Barbonymus gonionotus

Published Online: Feb 14, 2018

Page range: 99 - 106

Received: Mar 28, 2017

Accepted: Oct 31, 2017

DOI: https://doi.org/10.1515/intox-2017-0016

Keywordspesticides, organophosphate, erythrocytes, nuclear abnormalities, micronucleus test, genotoxicity

© 2017 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
pesticides, organophosphate, erythrocytes, nuclear abnormalities, micronucleus test, genotoxicity