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Journals
Helminthologia
Volume 53 (2016): Issue 2 (June 2016)
Open Access
Detrimental effects of geldanamycin on adults and larvae of
Trichinella spiralis
A. A. Othman
A. A. Othman
and
Z. S. Shoheib
Z. S. Shoheib
| Apr 22, 2016
Helminthologia
Volume 53 (2016): Issue 2 (June 2016)
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Article Category:
Research Article
Published Online:
Apr 22, 2016
Page range:
126 - 132
Received:
Dec 03, 2015
Accepted:
Feb 22, 2016
DOI:
https://doi.org/10.1515/helmin-2016-0003
© 2016 Institute of Parasitology, SAS, Košice
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Fig. 1
Photomicrographs of skeletal muscle sections 5 weeks p.i. showing: A,C encapsulated larvae from the control infected mice. The collagenous capsule (thick arrow) surrounds sections of Trichinella larvae (thin arrow) (PAS, H&E × 400). B,D thinning of the capsule (thick arrow) around the larvae (thin arrow) in the treated mice (PAS, H&E × 400). E, mild to moderate inflammatory reactions around larvae in the control group (H&E × 100). F, moderate to marked intensity of inflammation around the encapsulated larvae and in between muscle fibres in the treated group (H&E × 65)
Fig. 2
Electron micrographs ofthebody wall of adult worms (A-D) and larvae (E,F):A, section in the body wall of an adult from control infected mouse (× 12,000). B, loss of the electron dense layer in the cuticle (arrow) is observed (× 25,000). C, separation of the cuticle from the underlying hypodermis (arrow) is noted (× 6000). D, there are blunting of the epicuticle and washed-out image of the cytoplasm (arrow) (× 10,000). E, section in the cuticle of a larva from the control group (× 20,000). F, disruption of the layers of the cuticle (arrows) is noted (× 25,000)
Muscle larval count in control and treated groups
Control (n=7)
Group 1 (n=7)
Group 2 (n=7)
Mean ± SD
25,428 ± 1,397
15,428 ± 975
8,142 ± 1,069
IE
---------
40.4 %
67.9 %
F. test
14.526
P
. value
0.001
Control & G1
Control & G2
G1 & G2
0.001
0.001
0.001