<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The eggs recovered during faecal screening of Asiatic lions (kept at MC Zoological Park, Punjab, India) were delineated as Toxascaris leonina eggs based on morphometric and molecular studies (polymerase chain reaction targeting internal transcribed spacer sequences). Therapeutic management with fenbendazole @10 mg/kg body weight, once daily orally for three consecutive days proved ineffective with maximum faecal egg count reduction (FECR) on day 3 post treatments (69.35 %). But, therapeutic intervention with extended period dose schedule (5 consecutive days) with fenbendazole (@10 mg/kg body weight) proved effective and showed a maximum FECR of 95.34 % at day 7 post treatments. But, when ivermectin (@100μg/kg body weight) was given orally on three alternate days, proved effective as FECR of 95.74 % was recorded at day 7 post treatments. Thus, present study highlights the molecular confi rmation of T. leonina and its management using fenbendazole and ivermectin in Asiatic lions.</p></abstract>

The eggs recovered during faecal screening of Asiatic lions (kept at MC Zoological Park, Punjab, India) were delineated as Toxascaris leonina eggs based on morphometric and molecular studies (polymerase chain reaction targeting internal transcribed spacer sequences). Therapeutic management with fenbendazole @10 mg/kg body weight, once daily orally for three consecutive days proved ineffective with maximum faecal egg count reduction (FECR) on day 3 post treatments (69.35 %). But, therapeutic intervention with extended period dose schedule (5 consecutive days) with fenbendazole (@10 mg/kg body weight) proved effective and showed a maximum FECR of 95.34 % at day 7 post treatments. But, when ivermectin (@100μg/kg body weight) was given orally on three alternate days, proved effective as FECR of 95.74 % was recorded at day 7 post treatments. Thus, present study highlights the molecular confi rmation of T. leonina and its management using fenbendazole and ivermectin in Asiatic lions.

Case Report. Internal transcribed spacer sequence based molecular confirmation and drug efficacy assessment against Toxascaris leonina (Linstow, 1909) infection in Asiatic lions (Panthera leo persica)

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The eggs recovered during faecal screening of Asiatic lions (kept at MC Zoological Park, Punjab, India) were delineated as Toxascaris leonina eggs based on...

Case Report. Internal transcribed spacer sequence based molecular confirmation and drug efficacy assessment against Toxascaris leonina (Linstow, 1909) infection in Asiatic lions (Panthera leo persica)

Published Online: May 17, 2017

Page range: 152 - 156

Received: Nov 23, 2016

Accepted: Mar 03, 2017

DOI: https://doi.org/10.1515/helm-2017-0019

Keywords
Asiatic lion, fenbendazole, ITSs, ivermectin, Toxascaris leonina

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Case Report. Internal transcribed spacer sequence based molecular confirmation and drug efficacy assessment against Toxascaris leonina (Linstow, 1909) infection in Asiatic lions (Panthera leo persica)

Published Online: May 17, 2017

Page range: 152 - 156

Received: Nov 23, 2016

Accepted: Mar 03, 2017

DOI: https://doi.org/10.1515/helm-2017-0019

KeywordsAsiatic lion, fenbendazole, ITSs, ivermectin, Toxascaris leonina

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Asiatic lion, fenbendazole, ITSs, ivermectin, Toxascaris leonina