The Role of Genetics in Sporadic GEP-NETs: A Comprehensive Review of the Literature
Published Online: Jun 30, 2017
Page range: 1 - 5
Received: Nov 28, 2016
Accepted: May 14, 2017
DOI: https://doi.org/10.1515/fco-2017-0001
Keywords
© 2017 George Fotopoulos, Ioannis Vathiotis, George C. Nikou, Konstantinos Syrigos
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Neuroendocrine tumors (NETs) are composed of a heterogeneous group of malignancies from neuroendocrine cell compartments, with roles in both the endocrine and the nervous system. The majority of NETs are gastroenteropancreatic (GEP) in origin, arising in the foregut, midgut, or hindgut. The genomic landscape of GEP-NETs has been scarcely studied in terms of genomic profiling.The following algorithm was followed using the keywords neuroendocrine, genomics, targeted therapy, personalized medicine, gastroenteropancreatic and NET. The search was performed in PubMed and ScienceDirect database. Our current knowledge of sporadic GEP-NETs genetics must be further advanced to elucidate the molecular basis and pathogenesis of the disease, improve the accuracy of diagnosis, and guide tailor-made therapies.