<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objective.</bold> Thrombotic thrombocytopenic purpura (TTP) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenic purpura, neurologic abnormalities, fever, and renal insufficiency. The association or co-existence of thyrotoxicosis or antithyroid drugs with TTP has not been previously reported.<bold>Subject and Results.</bold> Herein, we present a 54-year-old female patient newly diagnosed with toxic multinodular goiter accompanying with TTP, possibly triggered by either thyrotoxicosis or antithyroid drugs.<bold>Conclusions.</bold> The present report is the first in the literature to demonstrate the co-existence of these two diseases and the use of plasma exchange as a modality to treat both conditions.</abstract>

Objective. Thrombotic thrombocytopenic purpura (TTP) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenic purpura, neurologic abnormalities, fever, and renal insufficiency. The association or co-existence of thyrotoxicosis or antithyroid drugs with TTP has not been previously reported.Subject and Results. Herein, we present a 54-year-old female patient newly diagnosed with toxic multinodular goiter accompanying with TTP, possibly triggered by either thyrotoxicosis or antithyroid drugs.Conclusions. The present report is the first in the literature to demonstrate the co-existence of these two diseases and the use of plasma exchange as a modality to treat both conditions.

Using plasma exchange to successfully manage thyrotoxicosis in a patient with possible antithyroid drug-related thrombotic thrombocytopenic purpura

Faculty of Medicine, Department of Internal Medicine

Faculty of Medicine, Department of Endocrinology

Faculty of Medicine, Department of Hematology

Endocrine Regulations

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objective. Thrombotic thrombocytopenic purpura (TTP) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenic purpura, neurologic...

Using plasma exchange to successfully manage thyrotoxicosis in a patient with possible antithyroid drug-related thrombotic thrombocytopenic purpura

Published Online: Aug 30, 2017

Page range: 153 - 156

DOI: https://doi.org/10.1515/enr-2017-0016

Keywords
toxic multinodular goiter, methimazole, thrombotic thrombocytopenic purpura, thyrotoxicosis, plasma exchange

© 2017 Tazegul G et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Using plasma exchange to successfully manage thyrotoxicosis in a patient with possible antithyroid drug-related thrombotic thrombocytopenic purpura

Published Online: Aug 30, 2017

Page range: 153 - 156

DOI: https://doi.org/10.1515/enr-2017-0016

Keywordstoxic multinodular goiter, methimazole, thrombotic thrombocytopenic purpura, thyrotoxicosis, plasma exchange

© 2017 Tazegul G et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
toxic multinodular goiter, methimazole, thrombotic thrombocytopenic purpura, thyrotoxicosis, plasma exchange