<abstract xmlns="http://www.w3.org/1999/xhtml">Recently, a trend has developed towards employing certain herbal medicines to manage hepatotoxicity. The present study is that of an assessment of the efficacy of a herbal preparation of Salivin (HPS), a combination of the herbs of Saussurea amara (L.)DC., Salsola collina Pall., Achillea asiatica Serg. and rhizomes of Glycyrrhiza uralensis Fisch, in rabbit models, against CCl4-induced hepatic damage. In so doing, an extract of HPS (200 mg/kg body weight/day), along with reference control tablets of Carsil (Silymarin 35 mg) (250 mg/kg body weight/day) (which is known for its hepatoprotective effects) were administered, along with the standard diet. The experimental group of rabbits received HPS orally for 28 days, which resulted in a decrease in blood enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), compared to the control. Evidenced by biochemical and histopathological studies, it is concluded that the polyherbal formulation HPS showed hepatoprotective activity against induced CCl4 hepatotoxicity in rabbits.</abstract>

Recently, a trend has developed towards employing certain herbal medicines to manage hepatotoxicity. The present study is that of an assessment of the efficacy of a herbal preparation of Salivin (HPS), a combination of the herbs of Saussurea amara (L.)DC., Salsola collina Pall., Achillea asiatica Serg. and rhizomes of Glycyrrhiza uralensis Fisch, in rabbit models, against CCl4-induced hepatic damage. In so doing, an extract of HPS (200 mg/kg body weight/day), along with reference control tablets of Carsil (Silymarin 35 mg) (250 mg/kg body weight/day) (which is known for its hepatoprotective effects) were administered, along with the standard diet. The experimental group of rabbits received HPS orally for 28 days, which resulted in a decrease in blood enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), compared to the control. Evidenced by biochemical and histopathological studies, it is concluded that the polyherbal formulation HPS showed hepatoprotective activity against induced CCl4 hepatotoxicity in rabbits.

The hepatoprotective activity of the herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

School of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences

New Medicine” Medical Institute of Mongolia

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Recently, a trend has developed towards employing certain herbal medicines to manage hepatotoxicity. The present study is that of an assessment of the efficacy...

The hepatoprotective activity of the herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

Published Online: Mar 03, 2015

Page range: 263 - 266

Received: Aug 22, 2014

Accepted: Sep 12, 2014

DOI: https://doi.org/10.1515/cipms-2015-0030

Keywords
salivin, carbon tetrachloride, hepatoprotective activity

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The hepatoprotective activity of the herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

Published Online: Mar 03, 2015

Page range: 263 - 266

Received: Aug 22, 2014

Accepted: Sep 12, 2014

DOI: https://doi.org/10.1515/cipms-2015-0030

Keywordssalivin, carbon tetrachloride, hepatoprotective activity

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
salivin, carbon tetrachloride, hepatoprotective activity