Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

[1] Boldyrev AA, Severin SE. The histidine-containing dipeptides, carnosine, and anserine: distribution, properties, and biological significance. Adv. Enz. Reg. 1990; 30: 175-193.Search in Google Scholar

[2] Stvolinsky S, Toropova K, Gordeeva M, Kazey V, Sato T, Meguro K, Boldyrev A. Carnosine and its (S)-Trolox™ derivative protect animals against oxidative stress. Amino. Acids. 2012; 43: 165-70.10.1007/s00726-012-1256-422389054Search in Google Scholar

[3] Stvolinsky SL, Bulygina ER, Fedorova TN, Meguro K, Sato T, Tyulina OV, Abe H, Boldyrev AA. Biological activity of novel synthetic derivatives of carnosine. Cell. Mol. Neurobiol. 2010; 30: 395-404.Search in Google Scholar

[4] Bauerova K, Ponist S, Kuncirova V, Mihalova D, Paulovicova E, Volpi N. Chondroitin sulfate effect on induced arthritis in rats. Osteoarthr. Cartil. 2011; 19: 1373- 1379. 10.1016/j.joca.2011.08.00621884808Search in Google Scholar

[5] Joe B, Griffiths MM, Remmers EF, Wilder RL. Animal models of rheumatoid arthritis and related inflammation. Curr. Rheumatol. Rep. 1999; 1: 139-148.Search in Google Scholar

[6] Sokolik, Tumova, Valentova, Švec. Anti-inflammatory activities of copper(II) and zinc(II) Y-methoxyphenoxyacetates (Y=2, 3 or 4) on carrageenan-induced edema. Acta Facultatis Pharmaceuticae Universitatis Comenianae. 2007; 54: 165-170.Search in Google Scholar

[7] Kay J, Calabrese L. The role of interleukin-1 in the pathogenesis of rheumatoid arthritis. Rheumatology. (Oxford) 2004; 43: iii2-iii9. 10.1093/rheumatology/keh20115150426Search in Google Scholar

[8] Stankovic A, Slavic V, Stamenkovic B, Kamenov B, Bojanovic M, Mitrovic DR. Serum and synovial fluid concentrations of CCL2 (MCP-1) chemokine in patients suffering rheumatoid arthritis and osteoarthritis reflect disease activity. Bratisl. Lek. Listy. 2009; 110: 641-646.Search in Google Scholar

[9] Gruber BL, Sorbi D, French D, L. Marchese MJ, Nuovo GJ, Kew RR, Arbeit LA. Markedly elevated serum MMP-9 (gelatinase B) levels in rheumatoid arthritis: a potentially useful laboratory marker. Clin. Immunol. Immunopathol. 1996; 78: 161-71. 10.1006/clin.1996.00258625558Search in Google Scholar