1. bookVolume 67 (2017): Issue 1 (March 2017)
Journal Details
License
Format
Journal
eISSN
1820-7448
First Published
25 Mar 2014
Publication timeframe
4 times per year
Languages
English
access type Open Access

Viral molecular and pathological investigations of Canid herpesvirus 1 infection associated respiratory disease and acute death in dogs

Published Online: 30 Mar 2017
Volume & Issue: Volume 67 (2017) - Issue 1 (March 2017)
Page range: 11 - 24
Received: 07 Jul 2016
Accepted: 04 Nov 2016
Journal Details
License
Format
Journal
eISSN
1820-7448
First Published
25 Mar 2014
Publication timeframe
4 times per year
Languages
English
Abstract

Canid herpesvirus 1 (CaHV-1) is a member of the canine infectious respiratory disease complex (CIRDC). The outcome of CaHV-1 infection can be occasionally fatal. So far, no information on CaHV-1 circulation in Thailand has been reported resulting in a lack of preventive strategies. In this study, nasal (NS) and oropharyngeal (OS) swabs were collected from 100 live dogs with respiratory distress. Among them, 23 pleural effusions were aspirated. A panel of CIRDC-associated viruses was screened by (RT)-PCR, including CaHV-1, CIV, CPIV, CDV, CRCoV and CAdV-2, for all collected samples. The CaHV-1 was detected in 32 dogs. Additionally, CaHV-1 was consistently detected in six pleural effusions. Most CaHV-1 infected dogs were over 5 years of age (43.8%) and expressed a mild nasal discharge. Pathological results of four three-month-old puppies, naturally moribund from respiratory disease, revealed a severe multifocal necrotic-hemorrhagic disease in several organs without pathognomonic inclusion bodies. They were only found to be CaHV-1 positive by PCR. Phylogenetic analysis demonstrated concordant results of CaHV-1 circulation in Thailand. Although mostly found as a co-infection with other CIRDC viruses (68.8%) it also occurred alone. Therefore, rapid ante-mortem diagnosis might facilitate the investigation of unclassical CaHV-1 infection, which is fatal in neonates and causes illness in annually core-vaccinated adults.

Keywords

1. Gaskell R, Willoughby K: Herpesviruses of carnivores. Vet Microbiol 1999, 69:73-88.10.1016/S0378-1135(99)00092-9Search in Google Scholar

2. Binn LN, Alford JP, Marcheicki RH, Keefe TJ, Beattie RJ, Wall HG: Studies of respiratory disease in random-source laboratory dogs: viral infection in unconditioned dogs. Lab Anim Sci 1979, 29:48-52.Search in Google Scholar

3. Erles K, Dubovi E, Brooks HW, Brownlie J: Longitudinal study of viruses associated with canine infectious respiratory disease. J Clin Microbiol 2004, 42:4524-4529.10.1128/JCM.42.10.4524-4529.200452236115472304Search in Google Scholar

4. Miyoshi M, Ishii Y, Takiguchi M, Takada A, Yasuda J, Hashimoto A, Okazaki K, Kida H: Detection of canine herpesvirus DNA in the ganglionic neurons and the lymph node lymphocytes of latently infected dogs. J Vet Med Sci 1999, 61:375-379.10.1292/jvms.61.37510342288Search in Google Scholar

5. Okuda Y, Ishida K, Hashimoto A, Yamaguchi T, Fukushi H, Hirai K, Carmichael LE: Virus reactivation in bitches with a medical history of herpesvirus infection. Am J Vet Res 1993, 54:551-554.Search in Google Scholar

6. Carmichael LE, Campbell ME, Krook L: Clinical and pathological features of a fatal viral disease of new born pups. Am J Vet Res 1996, 26:803-814.Search in Google Scholar

7. Hashimoto A, Hirai K, Yamaguchi T, Fujimoto Y: Experimental transplacental infection of pregnant dogs with canine herpesvirus. Am J Vet Res 1982, 43:844-850.Search in Google Scholar

8. Gadsden BJ, Maes RK, Wise AG, Kiupel M, Langohr IM: Fatal Canid herpesvirus 1 infection in an adult dog. J Vet Diag Invest 2012, 24:604-607.10.1177/104063871244099422529135Search in Google Scholar

9. Kumar S, Driskell EA, Cooley AJ, Jia K, Blackmon S, Wan XF, Uhl EW, Saliki JT, Sanchez S, Krimer PM, Hogan RJ: Fatal canid herpesvirus 1 respiratory infections in 4 clinically healthy adult dogs. Vet Pathol 2015, 52:681-687.10.1177/030098581455619025358536Search in Google Scholar

10. Greene CE, Carmichael LE: Canine herpesvirus infection. In: Infectious Diseases of the Dog and Cat. 3rd ed., New York, USA: Saunders Elsevier; 2006, 47-53.Search in Google Scholar

11. Larsen RW, Kiupel M, Balzer HJ, Agerholm JS: Prevalence of canid herpesvirus-1 infection in stillborn and dead neonatal puppies in Denmark. Acta Vet Scand 2015:57.10.1186/s13028-014-0092-9429669025567292Search in Google Scholar

12. Remond M, Sheldrich P, Lebreton F, Nardeux P, Foulon T: Gene organization in the UL region and inverted repeats of the canine herpesvirus genome. J Gen Virol 1996, 77:37-48.10.1099/0022-1317-77-1-378558127Search in Google Scholar

13. Rota PA, Maes RK: Homology between feline herpesvirus-1 and canine herpesvirus. Arch Virol 1990, 115:1394-1399.10.1007/BF013106312174232Search in Google Scholar

14. Krakowka S: Canine herpesvirus-1. In: Comparative pathobiology of viral disease. Boca Raton, Forida, USA:, CRC Press; 1985, 137-144.10.1201/9780429286629-9Search in Google Scholar

15. Nakamichi K, Ohara K, Matsumoto Y, Otsuka H: Attachment and penetration of canine herpesvirus 1 in non-permissive cells. J Vet Med Sci 2000, 62:965–970.10.1292/jvms.62.96511039592Search in Google Scholar

16. Kawakami K, Ogawa H, Maeda K, Imai A, Ohashi E, Matsunaga S, Tohya Y, Ohshima T, Mochizuki M: Nosocomial outbreak of serious canine infectious tracheobronchitis (Kennel Cough) caused by canine herpesvirus infection. J Clin Microbiol 2010, 8:1176-1181.10.1128/JCM.02128-09284957720107103Search in Google Scholar

17. Decaro N, Amorisco F, Desario C, Lorusso E, Camero M, Bellacicco AL, Sciarretta R, Lucente MS, Martella V, Buonavoglia C: Development and validation of a real-time PCR assay for specific and sensitive detection of canid herpesvirus 1. J Virol Methods 2010, 169:176–180.10.1016/j.jviromet.2010.07.021711286720674611Search in Google Scholar

18. Piewbang C, Rungsipipat A, Poovorawan Y, Techangamsuwan S: Development and application of multiplex PCR assays for detection of virus-induced respiratory disease complex in dogs. J Vet Med Sci 2016, 78: 1847-1854.10.1292/jvms.16-0342524076427628592Search in Google Scholar

19. Radtanakatikanon A, Keawcharoen J, Charoenvisal N, Poovorawan Y, Prompetchara E, Yamaguchi R, Techangamsuwan S: Genotypic lineages and restriction fragment length polymorphism of canine distemper virus isolates in Thailand. Vet Microbiol 2013, 166:76-83.10.1016/j.vetmic.2013.05.01523830775Search in Google Scholar

20. Malone EK, Ledbetter EC, Rassnick KM, Kim SG, Russel D: Disseminated canine herpesvirus-1 infection in an immunocompromised adult dog. J Vet Intern Med 2010, 24:965–968.10.1111/j.1939-1676.2010.0512.x20412440Search in Google Scholar

21. Decaro N, Martella V, Buonavoglia C: Canine adenoviruses and herpesvirus. Vet Clin North Am Small Anim Pract 2008, 38:799–814, viii.10.1016/j.cvsm.2008.02.006711486518501279Search in Google Scholar

22. Kapil S: Canid herpesvirus 1 (CHV-1)-related disease in older puppies and CHV-1 shedding in the vagina of adult pregnant dogs. J Vet Diag Invest 2015, 27:758-761.10.1177/104063871561037726450840Search in Google Scholar

23. Hanedan B, Kirbas A, Dorman E, Timurkan MO, Kandemir FM, Alkan O: Cardiac tropinin-I concentration in weaned calves with bovine respiratory disease. Acta Vet-Beograd 2015, 65:454-462.10.1515/acve-2015-0038Search in Google Scholar

24. van Elk CE, van de Bildt MWG, de Jong AAW, Osterhaus ADME, Kuiken T: Genital herpesvirus in bottlenose dolphins (Tursiops Truncatus): cultivation, epidemiology, and associated pathology. J Wildl Dis 2009, 45:895-906.10.7589/0090-3558-45.4.89519901366Search in Google Scholar

25. Woźniakowski G, Samorek-salamonowicz E: Animal herpesviruses and their zoonotic potential for cross-species infection. Ann Agric Environ Med 2015, 22:191-194.10.5604/12321966.115206326094506Search in Google Scholar

26. Seo IB, Lim CH: Study on the pathogenesis of canine herpesvirus infection. II. Immunohistochemical observations. Korean J Vet Res 1994, 34:583.Search in Google Scholar

27. Schulze C, Baumgartner W: Nested polymerase chain reaction and In situ hybridization for diagnosis of canine herpesvirus infection in puppies. Vet Pathol 1998, 35:209-217.10.1177/030098589803500306Search in Google Scholar

28. DeBiasi RL, Kleinschmidt-DeMasters BK, Weinberg A, Tyler KL: Use of PCR for the diagnosis of herpesvirus infections of the central nervous system. J Clin Virol 2002, 25:S5-S11.10.1016/S1386-6532(02)00028-8Search in Google Scholar

29. Mills AM, Guo FP, Copland AP, Pai RK, Pinsky BA: A comparison of CMV detection in gastrointestinal mucosal biopsies using immunohistochemistry and PCR performed on formalin-fixed, paraffin-embedded tissue. Am J Surg Pathol 2013, 37:995-1000.10.1097/PAS.0b013e31827fcc33Search in Google Scholar

30. Sagazio P, Cirone F, Pratelli A, Tempesta M, Buonavoglia D, Sasanelli M, Rubino G: Infezione da herpesvirus del cane: diffusion sierologica in Puglia. Obiettivi eDocumenti Veterinari, 1998, 5:63-67.Search in Google Scholar

31. Rijsewijk FA, Luiten EJ, Daus FJ, van der Heijden RW, van Oirschot JT: Prevalence of antibodies against canine herpesvirus-1 in dogs in the Netherlands in 1997-1998. Vet Microbiol 1999, 65:1-7.10.1016/S0378-1135(98)00285-5Search in Google Scholar

32. Ronsse V, Verstegen J, Onclin K, Guiot AL, Aeberle C, Nauwynck HJ: Seroprevalence of canine herpesvirus-1 in the Belgian dog population in 2000. Reprod Domest Anim 2002, 37:299-304.10.1046/j.1439-0531.2002.00363.x12354184Search in Google Scholar

33. Reading MJ, Field HJ: Detection of high levels of canine herpes virus-1 neutralizing antibody in kennel dogs using novel serum neutralization test. Res Vet Sci 1999, 66:273-275.10.1053/rvsc.1998.022210333471Search in Google Scholar

34. Seo IB, Seong WW, Lim, CH: Survey on epidemiology of canine herpesvirus infection in Korea. Korean J Vet Res 1994, 34:647-652.Search in Google Scholar

35. Poulet H, Guigal PM, Soulier M, Leroy V, Fayet G, Minke J, Chappuis Merial G: Protection of puppies against canine herpesvirus by vaccination of the dams. Vet Rec 2001, 148:691-695.10.1136/vr.148.22.69111425256Search in Google Scholar

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