<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The purpose of the present study was to evaluate serum canine Cystatin-C (Cys-C) concentration for the prediction of renal function (RF) in dogs naturally infected with <italic>Babesia canis vogeli</italic> and <italic>Ehrlichia canis.</italic> A total of 46 dogs were enrolled into three groups. Group B included 16 dogs naturally infected with <italic>B. c. vogeli</italic>, group E 10 dogs naturally infected with <italic>E. canis</italic> [dogs diagnosed as canine monocytic ehrlichiosis (CME)], and group H involved 20 healthy controls (negative for <italic>B. c. vogeli</italic> and <italic>E. canis</italic>). Solely dogs presenting uncomplicated babesiosis caused by <italic>B. c. vogeli</italic> were enrolled. Serum urea and serum creatinine (Cre) levels with serum Urea:Cre ratios were analyzed. Canine serum Cys-C was determined with a species-specific commercially available and validated ELISA assay as a reference. Mean serum Cys-C levels were 5.28 mg/L, 3.02 mg/L, and 2.30 mg/L for groups B, E and H, respectively. RF in uncomplicated CB caused by <italic>B. c. vogeli</italic> seems to be affected based on serum Cys-C concentrations. To the author's knowledge, this is the first study reporting that mean serum canine Cys-C levels in dogs with CME demonstrated no elevation. Serum canine Cys-C as a novel RF marker could be used for early detection of renal injury in both babesiosis and CME.</p></abstract>

The purpose of the present study was to evaluate serum canine Cystatin-C (Cys-C) concentration for the prediction of renal function (RF) in dogs naturally infected with Babesia canis vogeli and Ehrlichia canis. A total of 46 dogs were enrolled into three groups. Group B included 16 dogs naturally infected with B. c. vogeli, group E 10 dogs naturally infected with E. canis [dogs diagnosed as canine monocytic ehrlichiosis (CME)], and group H involved 20 healthy controls (negative for B. c. vogeli and E. canis). Solely dogs presenting uncomplicated babesiosis caused by B. c. vogeli were enrolled. Serum urea and serum creatinine (Cre) levels with serum Urea:Cre ratios were analyzed. Canine serum Cys-C was determined with a species-specific commercially available and validated ELISA assay as a reference. Mean serum Cys-C levels were 5.28 mg/L, 3.02 mg/L, and 2.30 mg/L for groups B, E and H, respectively. RF in uncomplicated CB caused by B. c. vogeli seems to be affected based on serum Cys-C concentrations. To the author's knowledge, this is the first study reporting that mean serum canine Cys-C levels in dogs with CME demonstrated no elevation. Serum canine Cys-C as a novel RF marker could be used for early detection of renal injury in both babesiosis and CME.

Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis

Department of Internal Medicine, Faculty of Veterinary Medicine, University of Ondokuz Mayis, 55139 Samsun/Turkey

Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, 09016 Aydin/Turkey

Department of Parasitology, Faculty of Veterinary Medicine, University of Adnan Menderes, 09016 Aydin/Turkey

Department of Biochemistry, Faculty of Veterinary Medicine, University of Ondokuz Mayis, 55139 Samsun/Turkey

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

PROCENA FUNKCIJE BUBREGA KOD BABEZIOZE I ERLIHIOZE PASA PREMA NIVOU CISTATIN-C

The purpose of the present study was to evaluate serum canine Cystatin-C (Cys-C) concentration for the prediction of renal function (RF) in dogs naturally...

Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis

Published Online: Mar 20, 2015

Page range: 56 - 65

Received: May 05, 2014

Accepted: Sep 22, 2014

DOI: https://doi.org/10.1515/acve-2015-0004

Keywords
Renal function, Cystatin-C, Canine,

© PEKMEZCI Didem, URAL Kerem, AYSUL Nuran, GUZEL Murat, CIFTCI Gulay

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis

Published Online: Mar 20, 2015

Page range: 56 - 65

Received: May 05, 2014

Accepted: Sep 22, 2014

DOI: https://doi.org/10.1515/acve-2015-0004

KeywordsRenal function, Cystatin-C, Canine,

© PEKMEZCI Didem, URAL Kerem, AYSUL Nuran, GUZEL Murat, CIFTCI Gulay

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Renal function, Cystatin-C, Canine,