1. bookVolume 8 (2015): Issue 2 (October 2015)
Journal Details
License
Format
Journal
eISSN
1339-3065
First Published
10 Dec 2012
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2 times per year
Languages
English
access type Open Access

Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines

Published Online: 05 Dec 2015
Volume & Issue: Volume 8 (2015) - Issue 2 (October 2015)
Page range: 97 - 100
Journal Details
License
Format
Journal
eISSN
1339-3065
First Published
10 Dec 2012
Publication timeframe
2 times per year
Languages
English
Abstract

New photosensitizers are needed for photodynamic antimicrobial and anticancer chemotherapy. Two new groups of proflavine derivatives have been recently prepared and their action on the cancer cells has been investigated by our research team. In this paper, we studied an effect of UV-A irradiation of two groups of proflavines: 3,6-bis((1-alkyl-5-oxo-imidazolidin-2-yliden)imino)acridine hydrochlorides (AcrDIMs) and 1’,1”-(acridin-3,6-diyl)-3’,3”-dialkyldithiourea hydrochlorides (AcrDTUs) on a plasmid DNA (pDNA). These compounds induced a photocleavage of pDNA characteristic by generation of free radicals, single strand DNA breaks and formation of an open circular form of pDNA.

Keywords

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