[1. D. M. Campoli-Richards, E. M. Sorkin and R. C. Heel, Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, Drugs 32 (1986) 383-424.10.2165/00003495-198632050-00001]Search in Google Scholar
[2. H. Ohnishi, H. Kosuzume, H. Inaba, M. Ohkura, S. Shimada and Y. Suzuki, The immunomodulatory action of inosiplex in relation to its effects in experimental viral infections, Int. J. Immunopharmacol. 5 (1983) 181-196.10.1016/0192-0561(83)90055-3]Search in Google Scholar
[3. H. Ohnishi, H. Kosuzume, H. Inaba, M. Okura, Y. Morita, H. Mochizuki and Y. Suzuki, Mechanism of host defence suppression induced by viral infection: mode of action of inosiplex as an antiviral agent, Infect. Immun. 38 (1982) 243-250.]Search in Google Scholar
[4. K. Y. Tsang, H. H. Fudenberg and M. J. Gnagy, Restoration of immune response of aging hamsters by treatment with isoprinosine, J. Clin. Invest. 71 (1983) 1750-1755; DOI: 10.1A2/JCI110930.10.1172/JCI110930]Search in Google Scholar
[5. J. Gutierrez, R. S. Issacson and B. S. Koppel, Subacute sclerosing panencephalitis: an update, Dev. Med. Child. Neurol. 52 (2010) 901-907; DOI: 10.1111/j.1469-8749.2010.03717.x.10.1111/j.1469-8749.2010.03717.x]Search in Google Scholar
[6. C. Pedersen, E. Sandstrocm, C. S. Petersen, G. Norkrans, J. Gerstoft , A. Karlsson, K. C. Christensen, C. Hakanson, P. Pehrson, J. O. Nielsen, H. J. Jucrgensen, and Scandinavian Isoprinosine Study Group, The efficacy of inosine pranobex in preventing the acquired immunodeficiency syndrome in patients with human immunodeficiency virus infection, New Engl. J. Med. 322 (1990) 1757-1763; DOI: 10.1056/NEJM199006213222501.10.1056/NEJM199006213222501]Search in Google Scholar
[7. T. Nakamura, N. Miyasaka, R. M. Pope, N. Talal and I. J. Russell, Immunomodulation by isoprinosine: effects on in vitro immune functions of lymphocytes from humans with autoimmune diseases, Clin. Exp. Immunol. 52 (1983) 67-74.]Search in Google Scholar
[8. J. W. Hadden, E. M. Hadden and R. G. Coffey, Isoprinosine augmentation of phytohemagglutinininduced lymphocyte proliferation, Infect. Immun. 13 (1976) 382-387.10.1128/iai.13.2.382-387.1976]Search in Google Scholar
[9. J. Litzman, J. Lokaj, M. Krejci, S. Pesak and G. Morgan, Isoprinosine does not protect against frequent respiratory tract infections in childhood, Eur. J. Pediatr. 158 (1999) 32-37.10.1007/s004310051005]Search in Google Scholar
[10. M. Gołębiowska-Wawrzyniak, K. Markiewicz, A. Kozar, P. Derentowicz, J. Czerwińska-Kartowicz, K. Jastrzębska-Janas, J. Wacławek, Z. M. Wawrzyniak and H. Siwinska-Gołębiowska, Immunological and clinical study on the therapeutic efficacy of inosine pranobex, Pol. Merkur. Lekarski 19 (2005) 379-382.]Search in Google Scholar
[11. P. Hersey and A. Edwards, Effect of isoprinosine on natural killer cell activity of blood mononuclear cells in vitro and in vivo, Int. J. Immunopharmacol. 6 (1984) 315-320; DOI: 10.1016/0192-0561(84)90048-1.10.1016/0192-0561(84)90048-1]Search in Google Scholar
[12. S. Milano, M. Dieli, S. Millott , M. D. Miceli, E. Maltese and E. Cillari, Effect of isoprinosine on IL-2, IFN-γ and IL-4 production in vivo and in vitro, Int. J. Immunopharmacol. 13 (1991) 1013-1018; DOI: 10.1016/0192-0561(91)90055-C.10.1016/0192-0561(91)90055-C]Search in Google Scholar
[13. S. Jiang and C. Dong, A complex issue on CD4+ T-cell subsets, Immunol. Rev. 252 (2013) 5-11; DOI: 10.1111/imr.12041.10.1111/imr.1204123405891]Search in Google Scholar
[14. S. McHugh, J. Deighton, I. Rifkin and P. Ewan, Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture, Eur. J. Immunol. 26 (1996) 1260-1265; DOI: 10.1002/eji.1830260612.10.1002/eji.18302606128647202]Search in Google Scholar
[15. B. Perussia, The cytokine profile of resting and activated NK cells, Methods 9 (1996) 370-378; DOI: 10.1084/jcm.20032058.]Search in Google Scholar
[16. M. Akdis, J. Verhagen, A. Taylor, F. Karamloo, C. Karagiannidis, R. Crameri, S. Thunberg, G. Deniz, R. Valenta, H. Fiebig, C. Kegel, R. Disch, C. B. Schmidt-Weber, K. Blaser and C. A. Akdis, Immune response in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells, J. Exp. Med. 199 (2004) 1567-1575.10.1084/jem.20032058221178215173208]Search in Google Scholar
[17. I. Striz, E. Brabcova, L. Kolesar and A. Sekerkova, Cytokine networking of innate immunity cells: a potential target of therapy, Clin. Sci. 126 (2014) 593-612; DOI: 10.1042/CS20130497.10.1042/CS2013049724450743]Search in Google Scholar
[18. B. K. Pedersen, N. Tvede, M. Diamant, J. Gerstoft , M. Bagge Hansen, P. M. Haahr, M. Hording, M. Kappel, M. Klokker, B. Soeberg and P. Skinhoj, Effects of isoprinosine treatment of HIV-positive patients on blood mononuclear cell subsets, NK- and T-cell function, tumor necrosis factor, and interleukins 1, 2, and 6, Scand. J. Immunol. 32 (1990) 641-649.10.1111/j.1365-3083.1990.tb03206.x1702899]Search in Google Scholar
[19. M. Petrova, D. Jelev and Z. Krastev, Isoprinosine affects serum cytokine levels in healthy adults, J. Interferon Cytokine Res. 30 (2010) 223-227; DOI: 10.1089/jir.2009.0057.10.1089/jir.2009.005720038210]Search in Google Scholar
[20. R. Sabat, G. Grutz, K. Warszawska, S. Kirsch, E. Witte, K. Wolk and J. Geginat, Biology of interleukin-10, Cytokine Growth Factor Rev. 21 (2010) 331-344; DOI: 1016/j.cytogfr.2010.09.002.10.1016/j.cytogfr.2010.09.00221115385]Search in Google Scholar
[21. A. Langkjaer, B. Kristensen, B. E. Hansen, H. Schultz, L. Hegedus and C. H. Nielsen, B-cell exposure to self-antigen induces IL-10 producing B cells as well as IL-6- and TNF-α-producing B-cell subsets in healthy humans, Clin. Immunol. 145 (2012) 1-10; DOI: 10.1016/j.clim.2012.07.004.10.1016/j.clim.2012.07.00422885146]Search in Google Scholar
[22. M. Saraiva and A. O’Garra, The regulation of IL-10 production by immune cells, Nat. Rev. Immunol. 10 (2010) 170-181; DOI: 10.103/nri2711.10.1038/nri271120154735]Search in Google Scholar
[23. G. Del Prete, M. De Carli, F. Almerigogna, M. G. Giudizi, R. Biagotti and S. Romagnani, Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation an cytokine production, J. Immunol. 150 (1993) 353-360.10.4049/jimmunol.150.2.353]Search in Google Scholar
[24. S. Gregori, K. S. Goudy and M. G. Roncarolo, The cellular and molecular mechanisms of immunosuppression by human type 1 regulatory T cells, Front. Immunol. 3 (2012), article 30; DOI: 10.3389/ fimmu.2012.00030.]Search in Google Scholar
[25. A. A. Navarini, M. Recher, K. S. Lang, P. Georgiev, S. Meury, A. Bergthaler, L. Flatz, J. Bille, R. Landmann, B. Odermatt , H. Hengartner and R. M. Zinkernagel, Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses, PNAS 103 (2006) 15335-15539; DOI: 10.1073/pnas.0607225103.]Search in Google Scholar
[26. W. W. Metzger and K. Sun, Immune dysfunction and bacterial coinfections following influenza, J. Immunol. 191 (2013) 2047-2052; DOI: 10.4049/jimmunol.1301152.10.4049/jimmunol.1301152376023523964104]Search in Google Scholar