<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This review article is concentrating on the news in the pathophysiology of chronic venous insufficiency (CVD). Despite ongoing progress in understanding the molecular aspects of CVD the exact mechanism of its development remains unclear. Many different factors may play role in the pathogenesis of CVD, including changes in hydrostatic pressure, valvular incompetence, increased capillary permeability, endothelial dysfunction, activation of leukocytes, deep venous obstruction, capillary microthrombosis, ineffective function of calf muscle pump, biochemical and structural changes in the vessel wall, extracellular matrix alteration, and several other mechanisms. A better understanding of the pathophysiology is an important step in the finding of new potential treatment.</p></abstract>

This review article is concentrating on the news in the pathophysiology of chronic venous insufficiency (CVD). Despite ongoing progress in understanding the molecular aspects of CVD the exact mechanism of its development remains unclear. Many different factors may play role in the pathogenesis of CVD, including changes in hydrostatic pressure, valvular incompetence, increased capillary permeability, endothelial dysfunction, activation of leukocytes, deep venous obstruction, capillary microthrombosis, ineffective function of calf muscle pump, biochemical and structural changes in the vessel wall, extracellular matrix alteration, and several other mechanisms. A better understanding of the pathophysiology is an important step in the finding of new potential treatment.

News in Pathogenesis of Chronic Venous Insufficiency

Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Department of Medical Biology

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"News in Pathogenesis of Chronic Venous Insufficiency"}

This review article is concentrating on the news in the pathophysiology of chronic venous insufficiency (CVD). Despite ongoing progress in understanding the...

News in Pathogenesis of Chronic Venous Insufficiency

Published Online: Sep 24, 2016

Page range: 5 - 12

Received: May 26, 2016

Accepted: Jun 20, 2016

DOI: https://doi.org/10.1515/acm-2016-0006

Keywords
chronic venous insufficiency, varicose veins, skin changes, leg ulcers, pathophysiology

© 2016 Mazuchova J et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

News in Pathogenesis of Chronic Venous Insufficiency

Published Online: Sep 24, 2016

Page range: 5 - 12

Received: May 26, 2016

Accepted: Jun 20, 2016

DOI: https://doi.org/10.1515/acm-2016-0006

Keywordschronic venous insufficiency, varicose veins, skin changes, leg ulcers, pathophysiology

© 2016 Mazuchova J et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
chronic venous insufficiency, varicose veins, skin changes, leg ulcers, pathophysiology