<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Background</h3><p>Gastric cancer (GC) is the common cause of cancer-related deaths worldwide and inflammation represents the early phases in the GC.</p></sec><sec><h3>Objective</h3><p>To review the tumor necrosis factor (TNF)-α-308 G>A (GG, GA, and AA) in GC by meta-analysis studies for any differences in TNF-α-308 G>A gene polymorphisms.</p></sec><sec><h3>Methods</h3><p>Case–control studies published from 2003 to 2017 were identified by searching PubMed, EMASE, and the Internet with the English language. The analysis published on TNF-α-308 G>A polymorphism was analyzed and a limited number of articles were included in the present study. TNF-α-308 G>A from 4,157 patients and 5,185 healthy controls was evaluated. Studies were evaluated using Cochrane <italic>Q</italic>-test and publication bias was evaluated by constructing funnel plots.</p></sec><sec><h3>Results</h3><p>Overall, TNF-α-308 GA genotype showed significant association [<italic>P</italic> &lt; 0.0001, odds ratio (OR), 95% confidence interval (CI) = 0.82 (0.74–0.91)]. However, meta-analysis of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) between GC patients and controls showed nonsignificant association with GC [<italic>P</italic> > 0.05, recessive model: OR = 1.38, 95% CI: 1.15–1.66; dominant model: OR = 1.23, 95% CI: 1.09–1.39; (G/A) vs. (G/G): OR = 1.15, 95% CI: 1.02–1.28; (A/A) vs. (G/G): OR = 1.44, 95% CI: 1.19–1.73]. Analysis stratified by ethnicity showed same results in Asian and Caucasian populations.</p></sec><sec><h3>Conclusions</h3><p>Results revealed nonsignificant association of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) and GC. TNF-α-308GA genotype showed significant association whereas homozygous genotype AA did not show association with GC risk.</p></sec></abstract>

BackgroundGastric cancer (GC) is the common cause of cancer-related deaths worldwide and inflammation represents the early phases in the GC.ObjectiveTo review the tumor necrosis factor (TNF)-α-308 G>A (GG, GA, and AA) in GC by meta-analysis studies for any differences in TNF-α-308 G>A gene polymorphisms.MethodsCase–control studies published from 2003 to 2017 were identified by searching PubMed, EMASE, and the Internet with the English language. The analysis published on TNF-α-308 G>A polymorphism was analyzed and a limited number of articles were included in the present study. TNF-α-308 G>A from 4,157 patients and 5,185 healthy controls was evaluated. Studies were evaluated using Cochrane Q-test and publication bias was evaluated by constructing funnel plots.ResultsOverall, TNF-α-308 GA genotype showed significant association [P < 0.0001, odds ratio (OR), 95% confidence interval (CI) = 0.82 (0.74–0.91)]. However, meta-analysis of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) between GC patients and controls showed nonsignificant association with GC [P > 0.05, recessive model: OR = 1.38, 95% CI: 1.15–1.66; dominant model: OR = 1.23, 95% CI: 1.09–1.39; (G/A) vs. (G/G): OR = 1.15, 95% CI: 1.02–1.28; (A/A) vs. (G/G): OR = 1.44, 95% CI: 1.19–1.73]. Analysis stratified by ethnicity showed same results in Asian and Caucasian populations.ConclusionsResults revealed nonsignificant association of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) and GC. TNF-α-308GA genotype showed significant association whereas homozygous genotype AA did not show association with GC risk.

A meta-analysis of tumor necrosis factor-α-308 G&gt;A polymorphism in gastric cancer

Department of Biotechnology, Government College for Women

Department of Gastrointestinal Colorectal and Anal Surgery

China–Japan Union Hospital of Jilin University

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A meta-analysis of tumor necrosis factor-α-308 G>A polymorphism in gastric cancer

BackgroundGastric cancer (GC) is the common cause of cancer-related deaths worldwide and inflammation represents the early phases in the GC.ObjectiveTo review the tumor necrosis factor (TNF)-α-308 G>A (GG, GA, and AA) in GC by meta-analysis studies for any differences in TNF-α-308 G>A gene polymorphisms.MethodsCase–control studies published from 2003 to 2017 were identified by searching PubMed, EMASE, and the Internet with the English language. The analysis published on TNF-α-308 G>A polymorphism was analyzed and a limited number of articles were included in the present study. TNF-α-308 G>A from 4,157 patients and 5,185 healthy controls was evaluated. Studies were evaluated using Cochrane Q-test and publication bias was evaluated by constructing funnel plots.ResultsOverall, TNF-α-308 GA genotype showed significant association [P  0.05, recessive model: OR = 1.38, 95% CI: 1.15–1.66; dominant model: OR = 1.23, 95% CI: 1.09–1.39; (G/A) vs. (G/G): OR = 1.15, 95% CI: 1.02–1.28; (A/A) vs. (G/G): OR = 1.44, 95% CI: 1.19–1.73]. Analysis stratified by ethnicity showed same results in Asian and Caucasian populations.ConclusionsResults revealed nonsignificant association of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) and GC. TNF-α-308GA genotype showed significant association whereas homozygous genotype AA did not show association with GC risk.

BackgroundGastric cancer (GC) is the common cause of cancer-related deaths worldwide and inflammation represents the early phases in the GC.ObjectiveTo review...

A meta-analysis of tumor necrosis factor-α-308 G>A polymorphism in gastric cancer

Article Category: Mini-review article

Published Online: Sep 10, 2020

Page range: 91 - 96

DOI: https://doi.org/10.1515/abm-2020-0014

Keywords
gastric cancer, meta-analysis, TNF-α-308

© 2020 Xin Jiang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A meta-analysis of tumor necrosis factor-α-308 G>A polymorphism in gastric cancer

Article Category: Mini-review article

Published Online: Sep 10, 2020

Page range: 91 - 96

DOI: https://doi.org/10.1515/abm-2020-0014

Keywordsgastric cancer, meta-analysis, TNF-α-308

© 2020 Xin Jiang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
gastric cancer, meta-analysis, TNF-α-308