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Baker JF, Walsh PM, Byrne DP, Mulhall KJ. In vitro assessment of human chondrocyte viability after treatment with local anesthetic, magnesium sulphate or normal saline. Knee Surg Sports Traumatol Arthrosc. 2011; 19:1043–6.BakerJFWalshPMByrneDPMulhallKJIn vitro assessment of human chondrocyte viability after treatment with local anesthetic, magnesium sulphate or normal salineKnee Surg Sports Traumatol Arthrosc2011191043610.1007/s00167-011-1437-9Search in Google Scholar
Piper SL, Kramer JD, Kim HT, Feeley BT. Effects of local anesthetics on articular cartilage. Am J Sports Med. 2011; 39:2245–53.PiperSLKramerJDKimHTFeeleyBTEffects of local anesthetics on articular cartilageAm J Sports Med20113922455310.1177/0363546511402780Search in Google Scholar
Chu CR, Izzo NJ, Coyle CH, Papas NE, Logar A. The in vitro effects of bupivacaine on articular chondrocytes. J Bone Joint Surg Br. 2008; 90:814–20.ChuCRIzzoNJCoyleCHPapasNELogarAThe in vitro effects of bupivacaine on articular chondrocytesJ Bone Joint Surg Br2008908142010.1302/0301-620X.90B6.20079Search in Google Scholar
Chu CR, Izzo NJ, Papas NE, Fu FH. In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes. Arthroscopy. 2006; 22:693–9.ChuCRIzzoNJPapasNEFuFHIn vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytesArthroscopy200622693910.1016/j.arthro.2006.05.006Search in Google Scholar
Piper SL, Kim HT. Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes. J Bone Joint Surg Am. 2008; 90:986–91.PiperSLKimHTComparison of ropivacaine and bupivacaine toxicity in human articular chondrocytesJ Bone Joint Surg Am2008909869110.2106/JBJS.G.01033Search in Google Scholar
Chu CR, Coyle CH, Chu CT, Szczodry M, Seshadri V, Karpie JC, et al. In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage. J Bone Joint Surg Am. 2010; 92:599–608.ChuCRCoyleCHChuCTSzczodryMSeshadriVKarpieJCet alIn vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilageJ Bone Joint Surg Am20109259960810.2106/JBJS.I.00425Search in Google Scholar
Gulihar A, Robati S, Twaij H, Salih A, Taylor GJ. Articular cartilage and local anaesthetic: a systematic review of the current literature. J Orthop. 2015; 12:S200–10.GuliharARobatiSTwaijHSalihATaylorGJArticular cartilage and local anaesthetic: a systematic review of the current literatureJ Orthop201512S2001010.1016/j.jor.2015.10.005Search in Google Scholar
Breu A, Rosenmeier K, Kujat R, Angele P, Zink W. The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage. Anesth Analg. 2013; 117:514–22.BreuARosenmeierKKujatRAngelePZinkWThe cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilageAnesth Analg20131175142210.1213/ANE.0b013e31829481edSearch in Google Scholar
Collins JB, Song J, Mahabir RC. Onset and duration of intradermal mixtures of bupivacaine and lidocaine with epinephrine. Can J Plast Surg. 2013; 21:51–3.CollinsJBSongJMahabirRCOnset and duration of intradermal mixtures of bupivacaine and lidocaine with epinephrineCan J Plast Surg20132151310.1177/229255031302100112Search in Google Scholar
Shang C, Cai C, Zhao C, Du Y. Synthesis and anti-inflammatory activity of gold-nanoparticle bearing a dermatan sulfate disaccharide analog. Chin Chem Lett. 2018; 29:81–3.ShangCCaiCZhaoCDuYSynthesis and anti-inflammatory activity of gold-nanoparticle bearing a dermatan sulfate disaccharide analogChin Chem Lett20182981310.1016/j.cclet.2017.06.010Search in Google Scholar
Anz A, Smith MJ, Stoker A, Linville C, Markway H, Branson K, Cook JL. The effect of bupivacaine and morphine in a coculture model of diarthrodial joints. Arthroscopy. 2009; 25:225–31.AnzASmithMJStokerALinvilleCMarkwayHBransonKCookJLThe effect of bupivacaine and morphine in a coculture model of diarthrodial jointsArthroscopy2009252253110.1016/j.arthro.2008.12.003Search in Google Scholar
Gulihar A, Shaunak S, Novak PL, Vinayakam P, Dhinsa B, Taylor G. Glucosamine reduces the inhibition of proteoglycan metabolism caused by local anaesthetic solution in human articular cartilage: an in vitro study. J Exp Orthop. 2017; 4:37. doi: 10.1186/s40634-017-0106-4GuliharAShaunakSNovakPLVinayakamPDhinsaBTaylorGGlucosamine reduces the inhibition of proteoglycan metabolism caused by local anaesthetic solution in human articular cartilage: an in vitro studyJ Exp Orthop201743710.1186/s40634-017-0106-4Open DOISearch in Google Scholar
Lee Y-J, Kim SA, Lee S-H. Hyaluronan suppresses lidocaine-induced apoptosis of human chondrocytes in vitro by inhibiting the p53-dependent mitochondrial apoptotic pathway. Acta Pharmacol Sin. 2016; 37:664–73.LeeY-JKimSALeeS-HHyaluronan suppresses lidocaine-induced apoptosis of human chondrocytes in vitro by inhibiting the p53-dependent mitochondrial apoptotic pathwayActa Pharmacol Sin2016376647310.1038/aps.2015.151Search in Google Scholar
Tian J, Li Y. Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes. Braz J Anesthesiol. 2016; 66:29–36.TianJLiYComparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytesBraz J Anesthesiol201666293610.1016/j.bjane.2015.01.006Search in Google Scholar
Cassuto J, Sinclair R, Bonderovic M. Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand. 2006; 50:265–82.CassutoJSinclairRBonderovicMAnti-inflammatory properties of local anesthetics and their present and potential clinical implicationsActa Anaesthesiol Scand2006502658210.1111/j.1399-6576.2006.00936.xSearch in Google Scholar
Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology. 2000; 93:858–75.HollmannMWDurieuxMELocal anesthetics and the inflammatory response: a new therapeutic indication?Anesthesiology2000938587510.1097/00000542-200009000-00038Search in Google Scholar
Saito T, Yamamoto Y, Feng GG, Kazaoka Y, Fujiwara Y, Kinoshita H. Lidocaine prevents oxidative stress-induced endothelial dysfunction of the systemic artery in rats with intermittent periodontal inflammation. Anesth Analg. 2017; 124:2054–62.SaitoTYamamotoYFengGGKazaokaYFujiwaraYKinoshitaHLidocaine prevents oxidative stress-induced endothelial dysfunction of the systemic artery in rats with intermittent periodontal inflammationAnesth Analg201712420546210.1213/ANE.0000000000002102Search in Google Scholar
Hattori M, Dohi S, Nozaki M, Niwa M, Shimonaka H. The inhibitory effects of local anesthetics on superoxide generation of neutrophils correlate with their partition coefficients. Anesth Analg. 1997; 84:405–12.HattoriMDohiSNozakiMNiwaMShimonakaHThe inhibitory effects of local anesthetics on superoxide generation of neutrophils correlate with their partition coefficientsAnesth Analg1997844051210.1213/00000539-199702000-00031Search in Google Scholar
Sharma JN, Al-Omran A, Parvathy SS. Role of nitric oxide in inflammatory diseases. Inflammopharmacology. 2007; 15:252–9.SharmaJNAl-OmranAParvathySSRole of nitric oxide in inflammatory diseasesInflammopharmacology200715252910.1007/s10787-007-0013-xSearch in Google Scholar
Simonaro CM, Haskins ME, Schuchman EH. Articular chondrocytes from animals with a dermatan sulfate storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidoses. Lab Invest. 2001; 81:1319–28.SimonaroCMHaskinsMESchuchmanEHArticular chondrocytes from animals with a dermatan sulfate storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidosesLab Invest20018113192810.1038/labinvest.3780345Search in Google Scholar
