<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes’ structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.</p></abstract>

Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes’ structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of...

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Article Category: Review article

Published Online: Mar 21, 2018

Page range: 301 - 314

DOI: https://doi.org/10.1515/abm-2018-0002

Keywords
drug-delivery system, medical applications, methods of preparation, niosomes, structure

© 2017 Pei Ling Yeo, Chooi Ling Lim, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Article Category: Review article

Published Online: Mar 21, 2018

Page range: 301 - 314

DOI: https://doi.org/10.1515/abm-2018-0002

Keywordsdrug-delivery system, medical applications, methods of preparation, niosomes, structure

© 2017 Pei Ling Yeo, Chooi Ling Lim, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
drug-delivery system, medical applications, methods of preparation, niosomes, structure