[
Aas J.A., A.L. Griffen, S.R. Dardis, A.M. Lee, I. Olsen, F.E. Dewhirst, E.J. Leys and Paster B.J. 2008. Bacteria of dental caries in primary and permanent teeth in children and young adults. J. Clin. Microbiol. 46(4): 1407–1417.
]Search in Google Scholar
[
Alcaraz L.D., P. Belda-Ferre, R. Cabrera-Rubio, H. Romero, A. Simon-Soro, M. Pignatelli and A. Mira. 2012. Identifying a healthy oral microbiome through metagenomics. Clin. Microbiol. Infect. 18(Suppl. 4): 54–57.10.1111/j.1469-0691.2012.03857.x22647051
]Search in Google Scholar
[
Astorga B., C. Barraza, J.M. Casals, M.J. Cisterna, D. Mena, F. Morales, S. González, O. de Oliveira Jnr. and G. Moncada. 2015. Advances in the study of oral bacterial diversity associated with dental caries by genomic study. Int. J. Odontostomat. 9(3): 349–356.10.4067/S0718-381X2015000300002
]Search in Google Scholar
[
Beighton D. 2005. The complex oral microflora of high-risk individuals and groups and its role in the caries process. Comm. Dent. Oral Epidemiol. 33(4): 248–255.10.1111/j.1600-0528.2005.00232.x16008631
]Search in Google Scholar
[
Belda-Ferre P., L.D. Alcaraz, R. Cabrera, H. Romero, A. Simon, M. Pignatelli and A. Mira. 2012. The oral metagenome in health and disease. ISME J. 6(1): 46–56.10.1038/ismej.2011.85324624121716308
]Search in Google Scholar
[
Belibasakis G.N. and E. Mylonakis. 2015. Oral infections: clinical and biological perspectives. Virulence 6(3): 173–176.10.1080/21505594.2015.1025191460147625830413
]Search in Google Scholar
[
Colak H., C.T. Dülgergil, M. Dalli and M.M. Hamidi. 2013. Early childhood caries update: A review of causes, diagnoses, and treatments. J. Nat. Sci. Biol. Med. 4(1): 29–38.
]Search in Google Scholar
[
Colombo A.P., S.K. Boches, S.L. Cotton, J.M. Goodson, R. Kent, A.D. Haffajee, S.S. Socransky, H. Hasturk, T.E. Van Dyke, F. Dewhirst and others. 2009. Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. J. Periodontol. 80(9): 1421–1432.10.1902/jop.2009.090185362736619722792
]Search in Google Scholar
[
Dewhirst F.E., T. Chen, J. Izard, B.J. Paster, A.C. Tanner, W.H. Yu, A. Lakshmanan and W.G. Wade. 2010. The human oral microbiome. J. Bacteriol. 192: 5002–5017.10.1128/JB.00542-10294449820656903
]Search in Google Scholar
[
Duran-Pinedo A.E. and J. Frias-Lopez. 2015. Beyond microbial community composition: functional activities of the oral microbiome in health and disease. Microbes Infect. 17: 505e516.10.1016/j.micinf.2015.03.014449564925862077
]Search in Google Scholar
[
Edelstein B.L. 2006. The dental caries pandemic and disparities problem. BMC Oral Health. 6(Suppl 1): S2.10.1186/1472-6831-6-S1-S2214759116934119
]Search in Google Scholar
[
Gooch B.F.
]Search in Google Scholar
[
, S.O. Griffin, S.K. Gray, W.G. Kohn, R.G. Rozier, M. Siegal, M. Fontana, D. Brunson, N. Carter, D.K. Curtis and others; Centers for Disease Control and Prevention. 2009. Preventing dental caries through school-based sealant programs: updated recommendations and reviews of evidence. J. Am. Dent. Assoc. 140(11): 1356–1365.
]Search in Google Scholar
[
Griffen A.L., C.J. Beall, J.H. Campbell, N.D. Firestone, P.S. Kumar, Z.K. Yang, M. Podar and E.J. Leys. 2012. Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing. ISME J. 6: 1176–1185.10.1038/ismej.2011.191335803522170420
]Search in Google Scholar
[
Gross E.L., C.J. Beall, S.R. Kutsch, N.D. Firestone, E.J. Leys and A.L. Griffen. 2012. Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis. PLoS ONE. 7(10): e47722.10.1371/journal.pone.0047722347297923091642
]Search in Google Scholar
[
Hajishengallis G., S. Liang, M.A. Payne, A. Hashim, R. Jotwani, M.A. Eskan, M.L. McIntosh, A. Alsam, K.L. Kirkwood, J.D. Lambris and others. 2011. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 10: 497–506.10.1016/j.chom.2011.10.006322178122036469
]Search in Google Scholar
[
Han Y.W. and X. Wang. 2013. Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J. Dent. Res. 92: 485–491.10.1177/0022034513487559365476023625375
]Search in Google Scholar
[
He J., Y. Li, Y. Cao, J. Xue and X. Zhou. 2015. The oral microbiome diversity and its relation to human diseases. Folia Microbiol. 60: 69.10.1007/s12223-014-0342-225147055
]Search in Google Scholar
[
Hsiao W.W.L., K.L. Li, Z. Liu, C. Jones, C.M. Fraser-Liggett and A.F. Fouad. 2012. Microbial transformation from normal oral microbiota to acute endodontic infections. BMC Genomics. 13: 345.10.1186/1471-2164-13-345343121922839737
]Search in Google Scholar
[
Jorth P., K.H. Turner, P. Gumus, N. Nizam, N. Buduneli and M. Whiteley. 2014. Metatranscriptomics of the human oral microbiome during health and disease. mBio. 5(2): e01012–14.10.1128/mBio.01012-14397735924692635
]Search in Google Scholar
[
Karpinski T.M. and A.K. Szkaradkiewicz. 2013. Microbiology of dental caries. J. Biol. Earth Sci. 3(1): M21–M24.
]Search in Google Scholar
[
Kawamura Y. and Y. Kamiya. 2012. Metagenomic analysis permitting identification of the minority bacterial populations in the oral microbiota. J. Oral Biosci. 54: 132–137.10.1016/j.job.2012.05.002
]Search in Google Scholar
[
Kumar P.S., A.L. Griffen, M.L. Moeschberger and E.J. Leys. 2005. Identification of candidate periodontal pathogens and beneficial species by quantitative 16S clonal analysis. J. Clin. Microbiol. 43: 3944–3955.10.1128/JCM.43.8.3944-3955.2005123392016081935
]Search in Google Scholar
[
Kuramitsu H.K. and B.Y. Wang. 2011. The whole is greater than the sum of its parts: dental plaque bacterial interactions can affect the virulence properties of cariogenic Streptococcus mutans. Am. J. Dent. 24(3): 153–154.
]Search in Google Scholar
[
Liu B.
]Search in Google Scholar
[
, L.L. Faller, N. Klitgord, V. Mazumdar, M. Ghodsi, D.D. Sommer, T.R. Gibbons, T.J. Treangen, Y.C. Chang, S. Li and others. 2012. Deep sequencing of the oral microbiome reveals signatures of periodontal disease. PLoS One 7: e37919.10.1371/journal.pone.0037919336699622675498
]Search in Google Scholar
[
Mang-de la Rosa M.R., L. Castellanos-Cosano, M.J. Romero-Perez and A. Cutando. 2014. The bacteremia of dental origin and its implications in the appearance of bacterial endocarditis. Med. Oral Patol. Oral Cir. Bucal. 19(1): e67–e73.10.4317/medoral.19562390943524121925
]Search in Google Scholar
[
Maurer P., E. Hoffman and H. Mast. 2009. Bacterial meningitis after tooth extraction. Br. Dent. J. 206: 69–71.10.1038/sj.bdj.2009.319165261
]Search in Google Scholar
[
Miller R.R.
]Search in Google Scholar
[
, V. Montoya, J.L. Gardy, D.M. Patrick and P. Tang. 2013. Metagenomics for pathogen detection in public health. Genome Med. 5(9): 81.10.1186/gm485397890024050114
]Search in Google Scholar
[
Moodley A., N.H. Wood and S.L. Shangase. 2013. The relationship between periodontitis and diabetes: a brief review. SADJ 68(260): 262–264.
]Search in Google Scholar
[
Munson M.A., T. Pitt-Ford, B. Chong, A. Weightman and W.G. Wade. 2002. Molecular and cultural analysis of the microflora associated with endodontic infections. J. Dent. Res. 81: 761–766.10.1177/081076112407091
]Search in Google Scholar
[
Narayanan L.L. and C. Vaishnavi. 2010. Endodontic microbiology. J. Conserv. Dent. 13(4): 233–239.
]Search in Google Scholar
[
Padmanabhan R., A.K. Mishra, D. Raoult and P.E. Fournier. 2013. Genomics and metagenomics in medical microbiology. J. Microbiol. Methods. 95(3): 415
]Search in Google Scholar
[
–424.
]Search in Google Scholar
[
Pappa H. and D.C. Jones. 2005. Mediastinitis from odontogenic infection. A case report. Br. Dent. J. 198: 547–548.10.1038/sj.bdj.481230215895047
]Search in Google Scholar
[
Petersen P.E.
]Search in Google Scholar
[
and P.C. Baehni. 2012. Periodontal health and global public health. Periodontol. 2000. 60(1): 7–14.
]Search in Google Scholar
[
Petersen P.E.
]Search in Google Scholar
[
, D. Bourgeois, H. Ogawa, S. Estupinan-Day and C. Ndiaye. 2005. The global burden of oral diseases and risks to oral health. Bull. World Health Org. 83(9): 661–669.
]Search in Google Scholar
[
Ribeiro A.C., F. Matarazzo, M. Faveri, D.M. Zezell and M.P.A. Mayer. 2011. Exploring bacterial diversity of endodontic microbiota by cloning and sequencing 16S rRNA. J. Endod. 37: 922–926.10.1016/j.joen.2011.04.00721689545
]Search in Google Scholar
[
Robertson D.P. 2015. Management of severe acute dental infections. Br. Med. J. 350: h1300.10.1136/bmj.h130025804417
]Search in Google Scholar
[
Santos A.L., J.F.J. Siqueira, I.N. Rocas, E.C. Jesus, A.S. Rosado and J.M. Tiedje. 2011. Comparing the bacterial diversity of acute and chronic dental root canal infections. PLoS One 6: e28088.10.1371/journal.pone.0028088322170022132218
]Search in Google Scholar
[
Scholtz M.B., C.C. Lo and P.S. Chain. 2012. Next generation sequencing and bioinformatic bottlenecks: the current state of metagenomic data analysis. Curr. Opin. Biotechnol. 23(1): 9
]Search in Google Scholar
[
–15.
]Search in Google Scholar
[
Simon-Soro A.
]Search in Google Scholar
[
, M. Guillen-Navarro and A. Mira. 2014. Metatran-scriptomics reveals overall active bacterial composition in caries lesions. J. Oral Microbiol. 6: 25443.10.3402/jom.v6.25443424749725626770
]Search in Google Scholar
[
Siqueira J.F.J., I.N. Rocas, R. Souto, M. de Uzeda and A.P. Colombo. 2000. Checkerboard DNA-DNA hybridization analysis of endodontic infections. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 89: 744–748.10.1067/moe.2000.10657610846131
]Search in Google Scholar
[
Siqueira J.F.J. and I.N. Rocas. 2009. Diversity of endodontic microbiota revisited. J. Dent. Res. 88: 969–981.10.1177/002203450934654919828883
]Search in Google Scholar
[
Siqueira J.F.J., F.R. Alves and I.N. Rocas. 2011. Pyrosequencing analysis of the apical root canal microbiota. J. Endod. 37: 1499–1503.10.1016/j.joen.2011.08.01222000451
]Search in Google Scholar
[
Sequeira J.F.J. and I.N. Rocas. 2013. Microbiology and treatment of acute apical abscesses. Clin. Microbiol. Rev. 26(2): 255–273.
]Search in Google Scholar
[
Slots J. and R.J. Genco. 1984. Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction. J. Dent. Res. 63: 412–421.
]Search in Google Scholar
[
Struzycka I. 2014. The oral microbiome in dental caries. Pol. J. Microbiol. 63(2): 127–135.
]Search in Google Scholar
[
Sukumar S., A.P. Roberts, F.E. Martin and C.J. Adler. 2016. Metagenomic insights into transferable antibiotic resistance in oral bacteria. J. Dent. Res. 95(9): 969–76.
]Search in Google Scholar
[
Tanner A.C.R. 2015. Anaerobic culture to detect periodontal and caries pathogens. J. Oral. Biosci. 57(1): 18–26.
]Search in Google Scholar
[
Tansirichaiya S., M.A. Rahman, A. Antepowicz, P. Mullany and A.P. Roberts. 2016. Detection of novel integrons in the metagenome of human saliva. PLoS One 11(6): 0157605.10.1371/journal.pone.0157605490925827304457
]Search in Google Scholar
[
Tavares W.L.F., L.C. Neves de Brito, R.P. Teles, M.L.A. Massara, A.P. Ribeiro Sobrinho, A.D. Haffajee, S.S. Socransky and F.R. Teles. 2011. Microbiota of deciduous endodontic infections analyzed by MDA and Checkerboard DNA-DNA hybridization. Int. Endod. J. 44(3): 225–235.
]Search in Google Scholar
[
Turaev D. and T. Rattei. 2016. High definition for systems biology of microbial communities: metagenomics gets genome-centric and strain-resolved. Curr. Opin. Biotechnol. 39: 174–181.10.1016/j.copbio.2016.04.01127115497
]Search in Google Scholar
[
Wang J., J. Qi, H. Zhao, S. He, Y. Zhang, S. Wei and F. Zhao. 2013. Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease. Sci. Rep. 3: 1843.10.1038/srep01843365448623673380
]Search in Google Scholar
[
World Health Organization (WHO). 2012. Oral health. Fact sheet. http://www.who.int/mediacentre/factsheets/fs318/en, 2016.10.30.
]Search in Google Scholar
[
Wu J., B.A. Peters, C. Dominianni, Y. Zhang, Z. Pei, L. Yang, Y. Ma, M.P. Purdue, E.J. Jacobs, S.M. Gapstur and others. 2016. Cigarette smoking and the oral microbiome in a large study of American adults. ISME J. 10(10): 2435–2446.10.1038/ismej.2016.37503069027015003
]Search in Google Scholar
[
Xu P. and J. Gunsolley. 2014. Application of metagenomics in understanding oral health and disease. Virulence 5(3): 424–432.10.4161/viru.28532397987024642489
]Search in Google Scholar
[
Zarco M.F., T.J. Vess and G.S. Ginsburg. 2012. The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Dis. 18(2): 10910.1111/j.1601-0825.2011.01851.x21902769
]Search in Google Scholar
[
–120.
]Search in Google Scholar
[
Zehnder M. and G.N. Belibasakis. 2015. On the dynamics of root canal infections – what we understand and what we don’t. Virulence 6(3): 216–222.10.4161/21505594.2014.984567460148925654162
]Search in Google Scholar
[
Zhou J., N. Jiang, S. Wang, X. Hu, K. Jiao, X. He, Z. Li and J. Wang. 2016. Exploration of human salivary microbiomes – insights into the novel characteristics of microbial community structure in caries and caries-free subjects. PLoS One 11(1): e0147039.10.1371/journal.pone.0147039471865726784334
]Search in Google Scholar
