This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Aducanumab. https://www.alzforum.org/therapeutics/aducanumab (03.03.2020)https://www.alzforum.org/therapeutics/aducanumab (03.03.2020)Search in Google Scholar
Alam J., Blackburn K., Patrick D.: Neflamapimod: Clinical phase 2b-ready oral small molecule inhibitor of p38α to reverse synaptic dysfunction in early Alzheimer’s disease. J. Prev. Alzheimers Dis., 2017; 4: 273–278AlamJ.BlackburnK.PatrickD.Neflamapimod: Clinical phase 2b-ready oral small molecule inhibitor of p38α to reverse synaptic dysfunction in early Alzheimer’s disease20174273278Search in Google Scholar
Amirrad F., Bousoik E., Shamloo K., Al-Shiyab H., Nguyen V.H., Montazeri Aliabadi H.: Alzheimer’s disease: Dawn of a new era? J. Pharm. Pharm. Sci., 2017; 20: 184–225AmirradF.BousoikE.ShamlooK.Al-ShiyabH.NguyenV.H.Montazeri AliabadiH.Alzheimer’s disease: Dawn of a new era?20172018422510.18433/J3VS8P28719360Search in Google Scholar
Arndt J.W., Qian F., Smith B.A., Quan C., Kilambi K.P., Bush M.W., Walz T., Pepinsky R.B., Bussière T., Hamann S., Cameron T.O., Weinreb P.H.: Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β. Sci. Rep., 2018; 8: 6412ArndtJ.W.QianF.SmithB.A.QuanC.KilambiK.P.BushM.W.WalzT.PepinskyR.B.BussièreT.HamannS.CameronT.O.WeinrebP.H.Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β20188641210.1038/s41598-018-24501-0591312729686315Search in Google Scholar
Axon announces positive results from phase II ADAMANT trial for AADvac1 in Alzheimer’s disease. https://www.prnewswire.com/news-releases/axon-announces-positive-results-from-phase-ii-adamant-trial-for-aadvac1-in-alzheimers-disease-300914509.html (03.03.2020)https://www.prnewswire.com/news-releases/axon-announces-positive-results-from-phase-ii-adamant-trial-for-aadvac1-in-alzheimers-disease-300914509.html (03.03.2020)Search in Google Scholar
Bachstetter A.D., Xing B., de Almeida L., Dimayuga E.R., Watterson D.M., Van Eldik L.J.: Microglial p38α MAPK is a key regulator of pro-inflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). J. Neuroinflammation, 2011; 8: 79BachstetterA.D.XingB.de AlmeidaL.DimayugaE.R.WattersonD.M.Van EldikL.J.Microglial p38α MAPK is a key regulator of pro-inflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)201187910.1186/1742-2094-8-79314250521733175Search in Google Scholar
Bakota L., Brandt R.: Tau biology and tau-directed therapies for Alzheimer’s disease. Drugs, 2016; 76: 301–313BakotaL.BrandtR.Tau biology and tau-directed therapies for Alzheimer’s disease20167630131310.1007/s40265-015-0529-0475760526729186Search in Google Scholar
Baranowska U., Wiśniewska R.J.: Receptor nikotynowy α7-nACh i jego znaczenie w funkcjonowaniu pamięci oraz wybranych chorobach ośrodkowego układu nerwowego. Postępy Hig. Med. Dośw., 2017; 71: 633–648BaranowskaU.WiśniewskaR.J.Receptor nikotynowy α7-nACh i jego znaczenie w funkcjonowaniu pamięci oraz wybranych chorobach ośrodkowego układu nerwowego201771633648Search in Google Scholar
Bearer E.L., Wu C.: Herpes simplex virus, Alzheimer’s disease and a possible role for Rab GTPases. Front. Cell Dev. Biol., 2019; 7: 134BearerE.L.WuC.Herpes simplex virus, Alzheimer’s disease and a possible role for Rab GTPases2019713410.3389/fcell.2019.00134669263431448273Search in Google Scholar
Boese A.C., Hamblin M.H., Lee J.P.: Neural stem cell therapy for neurovascular injury in Alzheimer’s disease. Exp. Neurol., 2020; 324: 113112BoeseA.C.HamblinM.H.LeeJ.P.Neural stem cell therapy for neurovascular injury in Alzheimer’s disease202032411311210.1016/j.expneurol.2019.11311231730762Search in Google Scholar
Buee L.: Dementia therapy targeting tau. Adv. Exp. Med. Biol., 2019; 1184: 407–416BueeL.Dementia therapy targeting tau2019118440741610.1007/978-981-32-9358-8_3032096053Search in Google Scholar
Bursavich M.G., Harrison B.A., Blain J.F.: Gamma secretase modulators: New Alzheimer’s drugs on the horizon? J. Med. Chem., 2016; 59: 7389–7409BursavichM.G.HarrisonB.A.BlainJ.F.Gamma secretase modulators: New Alzheimer’s drugs on the horizon?2016597389740910.1021/acs.jmedchem.5b0196027007185Search in Google Scholar
Caraci F., Leggio G.M., Salomone S., Drago F.: New drugs in psychiatry: Focus on new pharmacological targets. F1000Res., 2017; 6: 397CaraciF.LeggioG.M.SalomoneS.DragoF.New drugs in psychiatry: Focus on new pharmacological targets2017639710.12688/f1000research.10233.1537342028408985Search in Google Scholar
Cebers G., Alexander R.C., Haeberlein S.B., Han D., Goldwater R., Ereshefsky L., Olsson T., Ye N., Rosen L., Russell M., Maltby J., Eketjäll S., Kugler A.R.: AZD3293: Pharmacokinetic and pharmacodynamic effects in healthy subjects and patients with Alzheimer’s disease. J. Alzheimers Dis., 2017; 55: 1039–1053CebersG.AlexanderR.C.HaeberleinS.B.HanD.GoldwaterR.EreshefskyL.OlssonT.YeN.RosenL.RussellM.MaltbyJ.EketjällS.KuglerA.R.AZD3293: Pharmacokinetic and pharmacodynamic effects in healthy subjects and patients with Alzheimer’s disease2017551039105310.3233/JAD-16070127767991Search in Google Scholar
Crenezumab. https://www.alzforum.org/therapeutics/crenezumab (03.03.2020)https://www.alzforum.org/therapeutics/crenezumab (03.03.2020)Search in Google Scholar
Cummings J., Lee G., Ritter A., Sabbagh M., Zhong K.: Alzheimer’s disease drug development pipeline: 2019. Alzheimers Dement., 2019; 5: 272–293CummingsJ.LeeG.RitterA.SabbaghM.ZhongK.Alzheimer’s disease drug development pipeline: 20192019527229310.1016/j.trci.2019.05.008661724831334330Search in Google Scholar
Cummings J.L., Tong G., Ballard C.: Treatment combinations for Alzheimer’s disease: Current and future pharmacotherapy options. J. Alzheimers Dis., 2019; 67: 779–794CummingsJ.L.TongG.BallardC.Treatment combinations for Alzheimer’s disease: Current and future pharmacotherapy options20196777979410.3233/JAD-180766639856230689575Search in Google Scholar
Degterev A., Ofengeim D., Yuan J.: Targeting RIPK1 for the treatment of human diseases. Proc. Natl. Acad. Sci. USA, 2019; 116: 9714– 9722DegterevA.OfengeimD.YuanJ.Targeting RIPK1 for the treatment of human diseases20191169714972210.1073/pnas.1901179116652553731048504Search in Google Scholar
DeVos S.L., Miller R.L., Schoch K.M., Holmes B.B., Kebodeaux C.S., Wegener A.J., Chen G., Shen T., Tran H., Nichols B., Zanardi T.A., Kordasiewicz H.B., Swayze E.E., Bennett C.F., Diamond M.I. i wsp.: Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci. Transl. Med., 2017; 9: eaag0481DeVosS.L.MillerR.L.SchochK.M.HolmesB.B.KebodeauxC.S.WegenerA.J.ChenG.ShenT.TranH.NicholsB.ZanardiT.A.KordasiewiczH.B.SwayzeE.E.BennettC.F.DiamondM.I.Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy20179eaag048110.1126/scitranslmed.aag0481579230028123067Search in Google Scholar
Dominy S.S., Lynch C., Ermini F., Benedyk M., Marczyk A., Konradi A., Nguyen M., Haditsch U., Raha D., Griffin C., Holsinger L.J., Arastu-Kapur S., Kaba S., Lee A., Ryder M.I. i wsp.: Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci. Adv., 2019; 5: eaau3333DominyS.S.LynchC.ErminiF.BenedykM.MarczykA.KonradiA.NguyenM.HaditschU.RahaD.GriffinC.HolsingerL.J.Arastu-KapurS.KabaS.LeeA.RyderM.I.Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors20195eaau333310.1126/sciadv.aau3333635774230746447Search in Google Scholar
Dong Y., Li X., Cheng J., Hou L.: Drug development for Alzheimer’s disease: Microglia induced neuroinflammation as a target? Int. J. Mol. Sci., 2019; 20: 558DongY.LiX.ChengJ.HouL.Drug development for Alzheimer’s disease: Microglia induced neuroinflammation as a target?20192055810.3390/ijms20030558638686130696107Search in Google Scholar
Egan M.F., Kost J., Voss T., Mukai Y., Aisen P.S., Cummings J.L., Tariot P.N., Vellas B., van Dyck C.H., Boada M., Zhang Y., Li W., Furtek C., Mahoney E., Harper Mozley L. i wsp.: Randomized trial of verubecestat for prodromal Alzheimer’s disease. N. Engl. J. Med., 2019; 380: 1408–1420EganM.F.KostJ.VossT.MukaiY.AisenP.S.CummingsJ.L.TariotP.N.VellasB.van DyckC.H.BoadaM.ZhangY.LiW.FurtekC.MahoneyE.Harper MozleyL.Randomized trial of verubecestat for prodromal Alzheimer’s disease20193801408142010.1056/NEJMoa1812840677607830970186Search in Google Scholar
Elayta. https://www.alzforum.org/therapeutics/elayta (03.03.2020)https://www.alzforum.org/therapeutics/elayta (03.03.2020)Search in Google Scholar
Elenbecestat. https://www.alzforum.org/therapeutics/elenbecestat (03.03.2020)https://www.alzforum.org/therapeutics/elenbecestat (03.03.2020)Search in Google Scholar
Farlow M.R., Andreasen N., Riviere M.E., Vostiar I., Vitaliti A., Sovago J., Caputo A., Winblad B., Graf A.: Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer’s disease. Alzheimers Res. Ther., 2015; 7: 23FarlowM.R.AndreasenN.RiviereM.E.VostiarI.VitalitiA.SovagoJ.CaputoA.WinbladB.GrafA.Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer’s disease201572310.1186/s13195-015-0108-3441046025918556Search in Google Scholar
Femminella G.D., Frangou E., Love S.B., Busza G., Holmes C., Ritchie C., Lawrence R., McFarlane B., Tadros G., Ridha B.H., Bannister C., Walker Z., Archer H., Coulthard E., Underwood B.R. i wsp.: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: Study protocol for a randomised controlled trial (ELAD study). Trials, 2019; 20: 191FemminellaG.D.FrangouE.LoveS.B.BuszaG.HolmesC.RitchieC.LawrenceR.McFarlaneB.TadrosG.RidhaB.H.BannisterC.WalkerZ.ArcherH.CoulthardE.UnderwoodB.R.Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: Study protocol for a randomised controlled trial (ELAD study)20192019110.1186/s13063-019-3259-x644821630944040Search in Google Scholar
Gantenerumab. https://www.alzforum.org/therapeutics/gantenerumab (03.03.2020)https://www.alzforum.org/therapeutics/gantenerumab (03.03.2020)Search in Google Scholar
Gaweł M., Potulska-Chromik A.: Choroby neurodegeneracyjne: Choroba Alzheimera i Parkinsona. Postępy Nauk Med., 2015; 7: 468–476GawełM.Potulska-ChromikA.Choroby neurodegeneracyjne: Choroba Alzheimera i Parkinsona20157468476Search in Google Scholar
Ge M., Zhang Y., Hao Q., Zhao Y., Dong B.: Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta-analysis. Brain Behav., 2018; 8: e00982GeM.ZhangY.HaoQ.ZhaoY.DongB.Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta-analysis20188e0098210.1002/brb3.982604370129877067Search in Google Scholar
George T.P.: Nicotinic receptor mechanisms in neuropsychiatric disorders: Therapeutic implications. Prim. Psychiatry, 2010; 17: 35–41GeorgeT.P.Nicotinic receptor mechanisms in neuropsychiatric disorders: Therapeutic implications2010173541Search in Google Scholar
Ghosh A.K., Cárdenas E.L., Osswald H.L.: The design, development, and evaluation of BACE1 inhibitors for the treatment of Alzheimer’s disease. W: Alzheimer’s Disease II. Topics in Medicinal Chemistry, vol 24, red.: M. Wolfe. Springer International Publishing, Cham 2016, 27–85GhoshA.K.CárdenasE.L.OsswaldH.L.The design, development, and evaluation of BACE1 inhibitors for the treatment of Alzheimer’s diseaseW:24red.:WolfeM.Springer International PublishingCham2016278510.1007/7355_2016_16Search in Google Scholar
Godyń J., Jończyk J., Panek D., Malawska B.: Therapeutic strategies for Alzheimer’s disease in clinical trials. Pharmacol. Rep., 2016; 68: 127–138GodyńJ.JończykJ.PanekD.MalawskaB.Therapeutic strategies for Alzheimer’s disease in clinical trials20166812713810.1016/j.pharep.2015.07.00626721364Search in Google Scholar
Gratuze M., Leyns C.E.G., Holtzman D.M.: New insights into the role of TREM2 in Alzheimer’s disease. Mol. Neurodegener., 2018; 13: 66GratuzeM.LeynsC.E.G.HoltzmanD.M.New insights into the role of TREM2 in Alzheimer’s disease2018136610.1186/s13024-018-0298-9630250030572908Search in Google Scholar
Hampel H., Mesulam M.M., Cuello A.C., Farlow M.R., Giacobini E., Grossberg G.T., Khachaturian A.S., Vergallo A., Cavedo E., Snyder P.J., Khachaturian Z.S.: The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain, 2018; 141: 1917–1933HampelH.MesulamM.M.CuelloA.C.FarlowM.R.GiacobiniE.GrossbergG.T.KhachaturianA.S.VergalloA.CavedoE.SnyderP.J.KhachaturianZ.S.The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease20181411917193310.1093/brain/awy132602263229850777Search in Google Scholar
Hull M., Sadowsky C., Arai H., Le Prince Leterme G., Holstein A., Booth K., Peng Y., Yoshiyama T., Suzuki H., Ketter N., Liu E., Ryan J.M.: Long-term extensions of randomized vaccination trials of ACC-001 and QS-21 in mild to moderate Alzheimer’s disease. Curr. Alzheimer Res., 2017; 14: 696–708HullM.SadowskyC.AraiH.Le Prince LetermeG.HolsteinA.BoothK.PengY.YoshiyamaT.SuzukiH.KetterN.LiuE.RyanJ.M.Long-term extensions of randomized vaccination trials of ACC-001 and QS-21 in mild to moderate Alzheimer’s disease20171469670810.2174/1567205014666170117101537554356728124589Search in Google Scholar
Hung S.Y., Fu W.M.: Drug candidates in clinical trials for Alzheimer’s disease. J. Biomed. Sci., 2017; 24: 47HungS.Y.FuW.M.Drug candidates in clinical trials for Alzheimer’s disease2017244710.1186/s12929-017-0355-7551635028720101Search in Google Scholar
Jadhav S., Avila J., Schöll M., Kovacs G.G., Kövari E., Skrabana R., Evans L.D., Kontsekova E., Malawska B., de Silva R., Buee L., Zilka N.: A walk through tau therapeutic strategies. Acta Neuropathol. Commun., 2019; 7: 22JadhavS.AvilaJ.SchöllM.KovacsG.G.KövariE.SkrabanaR.EvansL.D.KontsekovaE.MalawskaB.de SilvaR.BueeL.ZilkaN.A walk through tau therapeutic strategies201972210.1186/s40478-019-0664-z637669230767766Search in Google Scholar
Kowalski K., Mulak A.: Brain-gut-microbiota axis in Alzheimer’s disease. J. Neurogastroenterol. Motil., 2019; 25: 48–60KowalskiK.MulakA.Brain-gut-microbiota axis in Alzheimer’s disease201925486010.5056/jnm18087632620930646475Search in Google Scholar
Krstic D., Knuesel I.: Deciphering the mechanism underlying late-onset Alzheimer disease. Nat. Rev. Neurol., 2013; 9: 25–34KrsticD.KnueselI.Deciphering the mechanism underlying late-onset Alzheimer disease20139253410.1038/nrneurol.2012.23623183882Search in Google Scholar
Lacosta A.M., Pascual-Lucas M., Pesini P., Casabona D., Pérez-Grijalba V., Marcos-Campos I., Sarasa L., Canudas J., Badi H., Monleón I., San-José I., Munuera J., Rodríguez-Gómez O., Abdelnour C., Lafuente A. i wsp.: Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: A randomised, double-blind, placebo-controlled, phase I trial. Alzheimers Res. Ther., 2018; 10: 12LacostaA.M.Pascual-LucasM.PesiniP.CasabonaD.Pérez-GrijalbaV.Marcos-CamposI.SarasaL.CanudasJ.BadiH.MonleónI.San-JoséI.MunueraJ.Rodríguez-GómezO.AbdelnourC.LafuenteA.Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: A randomised, double-blind, placebo-controlled, phase I trial2018101210.1186/s13195-018-0340-8578964429378651Search in Google Scholar
Lee J.K., Kim N.J.: Recent advances in the inhibition of p38 MAPK as a potential strategy for the treatment of Alzheimer’s disease. Molecules, 2017; 22: 1287–1310LeeJ.K.KimN.J.Recent advances in the inhibition of p38 MAPK as a potential strategy for the treatment of Alzheimer’s disease2017221287131010.3390/molecules22081287615207628767069Search in Google Scholar
Lopez Lopez C., Caputo A., Liu F., Riviere M.E., Rouzade-Dominguez M.L., Thomas R.G., Langbaum J.B., Lenz R., Reiman E.M., Graf A., Tariot P.N.: The Alzheimer’s Prevention Initiative Generation Program: Evaluating CNP520 efficacy in the prevention of Alzheimer’s disease. J. Prev. Alzheimers Dis., 2017; 4: 242–246Lopez LopezC.CaputoA.LiuF.RiviereM.E.Rouzade-DominguezM.L.ThomasR.G.LangbaumJ.B.LenzR.ReimanE.M.GrafA.TariotP.N.The Alzheimer’s Prevention Initiative Generation Program: Evaluating CNP520 efficacy in the prevention of Alzheimer’s disease2017424224610.14283/jpad.2017.3729181489Search in Google Scholar
Maia M.A., Sousa E.: BACE-1 and γ-secretase as therapeutic targets for Alzheimer’s disease. Pharmaceuticals, 2019; 12: E41MaiaM.A.SousaE.BACE-1 and γ-secretase as therapeutic targets for Alzheimer’s disease201912E4110.3390/ph12010041646919730893882Search in Google Scholar
Marszałek M.: Choroba Alzheimera a produkty degradacji białka APP. Formowanie i różnorodność form fibrylujących peptydów – wybrane aspekty. Postępy Hig. Med. Dośw., 2016; 70: 787–796MarszałekM.Choroba Alzheimera a produkty degradacji białka APP. Formowanie i różnorodność form fibrylujących peptydów – wybrane aspekty20167078779610.5604/17322693.120921027383575Search in Google Scholar
Marszałek M.: Cukrzyca typu 2 a choroba Alzheimera – jedna czy dwie choroby? Mechanizmy asocjacji. Postępy Hig. Med. Dośw., 2013; 67: 653–671MarszałekM.Cukrzyca typu 2 a choroba Alzheimera – jedna czy dwie choroby?20136765367110.5604/17322693.105954924018430Search in Google Scholar
Medina M.: An overview on the clinical development of tau-based therapeutics. Int. J. Mol. Sci., 2018; 19: 1160MedinaM.An overview on the clinical development of tau-based therapeutics201819116010.3390/ijms19041160597930029641484Search in Google Scholar
Novak P., Schmidt R., Kontsekova E., Kovacech B., Smolek T., Katina S., Fialova L., Prcina M., Parrak V., Dal-Bianco P., Brunner M., Staffen W., Rainer M., Ondrus M., Ropele S. i wsp.: FUNDAMANT: An interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease. Alzheimers Res. Ther., 2018; 10: 108NovakP.SchmidtR.KontsekovaE.KovacechB.SmolekT.KatinaS.FialovaL.PrcinaM.ParrakV.Dal-BiancoP.BrunnerM.StaffenW.RainerM.OndrusM.RopeleS.FUNDAMANT: An interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease20181010810.1186/s13195-018-0436-1620158630355322Search in Google Scholar
Okamoto M., Gray J.D., Larson C.S., Kazim S.F., Soya H., McEwen B.S., Pereira A.C.: Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease. Transl. Psychiatry, 2018; 8: 153OkamotoM.GrayJ.D.LarsonC.S.KazimS.F.SoyaH.McEwenB.S.PereiraA.C.Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease2018815310.1038/s41398-018-0201-z609242630108205Search in Google Scholar
Panza F., Lozupone M., Watling M., Imbimbo B.P.: Do BACE inhibitor failures in Alzheimer patients challenge the amyloid hypothesis of the disease? Expert Rev. Neurother., 2019; 19: 599–602PanzaF.LozuponeM.WatlingM.ImbimboB.P.Do BACE inhibitor failures in Alzheimer patients challenge the amyloid hypothesis of the disease?20191959960210.1080/14737175.2019.162175131112433Search in Google Scholar
Pasinetti G.M., Wang J., Ho L., Zhao W., Dubner L.: Roles of resveratrol and other grape-derived polyphenols in Alzheimer’s disease prevention and treatment. Biochim. Biophys. Acta, 2015; 1852: 1202–1208PasinettiG.M.WangJ.HoL.ZhaoW.DubnerL.Roles of resveratrol and other grape-derived polyphenols in Alzheimer’s disease prevention and treatment201518521202120810.1016/j.bbadis.2014.10.006438083225315300Search in Google Scholar
Payesko J.: GRF6019 Shows Positive Phase 2 Results in Mild to Moderate Alzheimer Disease. https://www.neurologylive.com/clinical-focus/grf6019-shows-positive-phase-2-results-in-mild-to-moderate-alzheimer-disease (03.03.2020)PayeskoJ.https://www.neurologylive.com/clinical-focus/grf6019-shows-positive-phase-2-results-in-mild-to-moderate-alzheimer-disease (03.03.2020)Search in Google Scholar
Petrov A.M., Lam M., Mast N., Moon J., Li Y., Maxfield E., Pikuleva I.A.: CYP46A1 Activation by efavirenz leads to behavioral improvement without significant changes in amyloid plaque load in the brain of 5XFAD mice. Neurotherapeutics, 2019; 16: 710–724PetrovA.M.LamM.MastN.MoonJ.LiY.MaxfieldE.PikulevaI.A.CYP46A1 Activation by efavirenz leads to behavioral improvement without significant changes in amyloid plaque load in the brain of 5XFAD mice20191671072410.1007/s13311-019-00737-0Search in Google Scholar
Safieh M., Korczyn A.D., Michaelson D.M.: ApoE4: An emerging therapeutic target for Alzheimer’s disease. BMC Med., 2019; 17: 64SafiehM.KorczynA.D.MichaelsonD.M.ApoE4: An emerging therapeutic target for Alzheimer’s disease2019176410.1186/s12916-019-1299-4Search in Google Scholar
Sanabria-Castro A., Alvarado-Echeverría I., Monge-Bonilla C.: Molecular pathogenesis of Alzheimer’s disease: An update. Ann. Neurosci., 2017; 24: 46–54Sanabria-CastroA.Alvarado-EcheverríaI.Monge-BonillaC.Molecular pathogenesis of Alzheimer’s disease: An update201724465410.1159/000464422Search in Google Scholar
Shaikh S., Rizvi S.M., Shakil S., Riyaz S., Biswas D., Jahan R.: Forxiga (dapagliflozin): Plausible role in the treatment of diabetes-associated neurological disorders. Biotechnol. Appl. Biochem., 2016; 63: 145–150ShaikhS.RizviS.M.ShakilS.RiyazS.BiswasD.JahanR.Forxiga (dapagliflozin): Plausible role in the treatment of diabetes-associated neurological disorders20166314515010.1002/bab.1319Search in Google Scholar
Siopi E., Llufriu-Dabén G., Cho A.H., Vidal-Lletjós S., Plotkine M., Marchand-Leroux C., Jafarian-Tehrani M.: Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuro-protection following traumatic brain injury in mice. Neuropharmacology, 2013; 67: 183–192SiopiE.Llufriu-DabénG.ChoA.H.Vidal-LletjósS.PlotkineM.Marchand-LerouxC.Jafarian-TehraniM.Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuro-protection following traumatic brain injury in mice20136718319210.1016/j.neuropharm.2012.11.009Search in Google Scholar
Smith A.: Positive results for UB-311 Alzheimer’s vaccine. http://www.pharmatimes.com/news/positive_results_for_ub-311_alzheimers_vaccine_1275579 (03.03.2020)SmithA.http://www.pharmatimes.com/news/positive_results_for_ub-311_alzheimers_vaccine_1275579 (03.03.2020)Search in Google Scholar
Solanezumab. https://www.alzforum.org/therapeutics/solanezumab (03.03.2020)https://www.alzforum.org/therapeutics/solanezumab (03.03.2020)Search in Google Scholar
The New Chinese Alzheimer’s Drug (GV-971) Making its Way to Global Trials: Material Science or Marketing?. https://www.trialsitenews.com/the-new-chinese-alzheimers-drug-gv-971-making-its-way-to-global-trials-material-science-or-marketing/ (25.05.2020)The New Chinese Alzheimer’s Drug (GV-971) Making its Way to Global Trialshttps://www.trialsitenews.com/the-new-chinese-alzheimers-drug-gv-971-making-its-way-to-global-trials-material-science-or-marketing/ (25.05.2020)Search in Google Scholar
TPI 287. https://www.alzforum.org/therapeutics/tpi-287 (03.03.2020)https://www.alzforum.org/therapeutics/tpi-287 (03.03.2020)Search in Google Scholar
Traneurocin Phase 2A Trial Results Show Improvements for People With Mild Cognitive Impairment. https://practicalneurology.com/index.php/news/traneurocin-phase-2a-trial-results-show-improvements-for-people-with-mild-cognitive-impairment (03.03.2020)https://practicalneurology.com/index.php/news/traneurocin-phase-2a-trial-results-show-improvements-for-people-with-mild-cognitive-impairment (03.03.2020)Search in Google Scholar
Umibecestat. https://www.alzforum.org/therapeutics/umibecestat (03.03.2020)https://www.alzforum.org/therapeutics/umibecestat (03.03.2020)Search in Google Scholar
Vellas B., Coley N., Ousset P.J., Berrut G., Dartigues J.F., Dubois B., Grandjean H., Pasquier F., Piette F., Robert P., Touchon J., Garnier P., Mathiex-Fortunet H., Andrieu S., GuidAge Study Group: Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer’s disease (GuidAge): A randomised placebo-controlled trial. Lancet Neurol., 2012; 11: 851–859VellasB.ColeyN.OussetP.J.BerrutG.DartiguesJ.F.DuboisB.GrandjeanH.PasquierF.PietteF.RobertP.TouchonJ.GarnierP.Mathiex-FortunetH.AndrieuS.GuidAge Study GroupLong-term use of standardised ginkgo biloba extract for the prevention of Alzheimer’s disease (GuidAge): A randomised placebo-controlled trial20121185185910.1016/S1474-4422(12)70206-5Search in Google Scholar
Verma S., Kumar A., Tripathi T., Kumar A.: Muscarinic and nicotinic acetylcholine receptor agonists: Current scenario in Alzheimer’s disease therapy. J. Pharm. Pharmacol., 2018; 70: 985–993VermaS.KumarA.TripathiT.KumarA.Muscarinic and nicotinic acetylcholine receptor agonists: Current scenario in Alzheimer’s disease therapy20187098599310.1111/jphp.1291929663387Search in Google Scholar
Wang X., Sun G., Feng T., Zhang J., Huang X., Wang T., Xie Z., Chu X., Yang J., Wang H., Chang S., Gong Y., Ruan L., Zhang G., Yan S. i wsp.: Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression. Cell Res., 2019; 29: 787–803WangX.SunG.FengT.ZhangJ.HuangX.WangT.XieZ.ChuX.YangJ.WangH.ChangS.GongY.RuanL.ZhangG.YanS.Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression20192978780310.1038/s41422-019-0216-x679685431488882Search in Google Scholar
Wisniewski T., Drummond E.: Developing therapeutic vaccines against Alzheimer’s disease. Expert Rev. Vaccines, 2016; 15: 401–415WisniewskiT.DrummondE.Developing therapeutic vaccines against Alzheimer’s disease20161540141510.1586/14760584.2016.1121815494085826577574Search in Google Scholar
Wojsiat J., Zoltowska K.M., Laskowska-Kaszub K., Wojda U.: Oxidant/antioxidant imbalance in Alzheimer’s disease: Therapeutic and diagnostic prospects. Oxid. Med. Cell. Longev., 2018; 2018: 6435861WojsiatJ.ZoltowskaK.M.Laskowska-KaszubK.WojdaU.Oxidant/antioxidant imbalance in Alzheimer’s disease: Therapeutic and diagnostic prospects20182018643586110.1155/2018/6435861583177129636850Search in Google Scholar
Xicota L., Rodriguez-Morato J., Dierssen M., de la Torre R.: Potential role of (-)-epigallocatechin-3-gallate (EGCG) in the secondary prevention of Alzheimer disease. Curr. Drug Targets, 2017; 18: 174–195XicotaL.Rodriguez-MoratoJ.DierssenM.de la TorreR.Potential role of (-)-epigallocatechin-3-gallate (EGCG) in the secondary prevention of Alzheimer disease20171817419510.2174/138945011666615082511365526302801Search in Google Scholar
Zhang C., Griciuc A., Hudry E., Wan Y., Quinti L., Ward J., Forte A.M., Shen X., Ran C., Elmaleh D.R., Tanzi R.E.: Cromolyn reduces levels of the Alzheimer’s disease-associated amyloid β-protein by promoting microglial phagocytosis. Sci. Rep., 2018; 8: 1144ZhangC.GriciucA.HudryE.WanY.QuintiL.WardJ.ForteA.M.ShenX.RanC.ElmalehD.R.TanziR.E.Cromolyn reduces levels of the Alzheimer’s disease-associated amyloid β-protein by promoting microglial phagocytosis20188114410.1038/s41598-018-19641-2577354529348604Search in Google Scholar
Zhang Y., Li P., Feng J., Wu M.: Dysfunction of NMDA receptors in Alzheimer’s disease. Neurol. Sci., 2016; 37: 1039–1047ZhangY.LiP.FengJ.WuM.Dysfunction of NMDA receptors in Alzheimer’s disease2016371039104710.1007/s10072-016-2546-5491757426971324Search in Google Scholar
Zhao Y., Zhao B.: Oxidative stress and the pathogenesis of Alzheimer’s disease. Oxid. Med. Cell. Longev., 2013; 2013: 316523ZhaoY.ZhaoB.Oxidative stress and the pathogenesis of Alzheimer’s disease2013201331652310.1155/2013/316523374598123983897Search in Google Scholar