SIRT1 (10q21.3) |
jądro komórkowe, cytoplazma |
H: H4K16, H3K9, H1K26, |
około 82 kDa [35, 91]
|
NH: FoxO, Ku70, p53, SREBP, TAFI68, PGAM1, UCP2, NF-κB, PGC1α, PPARγ |
|
SIRT2 (19q13.1) |
jądro komórkowe, cytoplazma |
H: H4K16, H3K6, H4K8 |
42 kDa [35]
|
NH: FoxO3a, FoxO1, α-tubulina, PEPCK1 |
|
SIRT3 (11p15.5) |
mitochondrium |
H: H3K9, H4K16 |
forma dłuższa : 44 kDa [35] forma krótsza: 28 kDa [86]
|
NH: FoxO3a, Ku70, GDH, SDH, OGG1 |
|
SIRT4 (12q) |
mitochondrium |
H: H3K9, H3K56 |
44 kDa [35]
|
NH: HIF1α, GCN5, CtIP, DNA-PK, PARP1 |
|
SIRT5 (6p25) |
mitochondrium, cytoplazma, jądro komórkowe |
NH: SDH, GLS, CPS1, PDC, UOX, HMGCS2 |
34 kDa [35, 91]
|
|
SIRT6 (19p13.3) |
jądro komórkowe |
H: H3K9, H3K56 |
39 kDa [35]
|
NH: HIF1α, GCN5, CtIP, DNA-PK, PARP1 |
|
SIRT7 (17q25) |
jądro komórkowe |
H: H3K18, H3K122 |
48 kDa [35]
|
NH: HIF1α, HIF2α, Myc, GABPβ1, PAF53, kompleks ligazy ubikwitynowej, polimeraza III |