INFORMAZIONI SU QUESTO ARTICOLO

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Figure 1

The median and interquartile ranges (25th; 75th percentiles) of serum AMH levels according to the Tanner genital stage.
The median and interquartile ranges (25th; 75th percentiles) of serum AMH levels according to the Tanner genital stage.

Figure 2

The median and interquartile ranges (25th; 75th percentiles) for LH (A), FSH (B), testosterone (C), and AMH (D) according to the Tanner genital stage between thalassemia major patients (white boxes) and control group (gray boxes), ** P < 0.05.
The median and interquartile ranges (25th; 75th percentiles) for LH (A), FSH (B), testosterone (C), and AMH (D) according to the Tanner genital stage between thalassemia major patients (white boxes) and control group (gray boxes), ** P < 0.05.

The testicular volume and basal LH, FSH, testosterone and AMH levels in patients with Thalassemia major and the controls

Genital TannernAge (y)Testicular volume (mL)LH (IU/L)FSH (IU/L)Testosterone (ng/dL)AMH (pmol/L)
Tanner I
     Thalassemia1510.6 ± 1.43<0.10.95<2.5726.86
(2–4)(<0.1–0.5)(0.3–1.42)(494.29–797.86)
     Control2610.6 ± 1.4<0.10.44<2.5769.16
(0.18–1.1)(<2.5–5.6)(587.7–1,073.4)
Tanner II
     Thalassemia511.5 ± 1.051.851.8210.66340.0
(4–7)(1.1–3.4)(1.3–2.0)(6.3–26.2)(203.82–570.68)
     Control1112.5 ± 0.92.32.246.1113.17
(1.4–3.5)(1.4–2.4)(19.2–188.8)(58.33–256.10)
(P = 0.058)
Tanner III
     Thalassemia413.3 ± 0.8123.42.7139.97113.32
(12–14.3)(1.8–5.4)(1.7–3.6)(80.9–290.6)(71.48–169.47)
     Control913.7 ± 0.82.71.5196.9975.69
(2.1–4.2)(1.3–2.0)(117.0–294.1)(55.25–134.84)
Tanner IV-V
     Thalassemia414.1 ± 1.0201.94.0290.8885.71
(14–20)(1.3–2.5)(1.4–6.4)(111.5–426.6)(33.75–173.89)
     Control1815.5 ± 2.01.55.6537.484.68
(1.2–2.3)(3.5–6.6)(394.6–720.6)(45.61–137.68)
P <0.05

The demographic characteristics of patients with thalassemia major

CharacteristicMean ± SD (range)
Recent age (y)11.7 ± 1.8 (8–14.9)
Height (SDS)−0.4 ± 0.87 (−2.3–1.5)
Weight (SDS)−0.04 ± 0.87 (−1.2–2.2)
Age at diagnosis of thalassemia (y)1.9 ± 1.1 (0.4–4.4)
Onset of blood transfusion (y)3.8 ± 2.3 (0.6–9.1)
Onset of chelation therapy (y)6.6 ± 2.8 (2–12.1)
Serum ferritin level before start chelation therapy (ng/mL)1,645 ± 536 (1,019–2,846)
Mean ferritin level in 1 year (ng/mL)1,575 ± 642 (534–3,207)
Mean hemoglobin level in 1 year (g/dL)8.9 ± 0.7 (7.1–10)
Maximum ferritin level (ng/mL)3,169 ± 1,184 (1,419–6,220)
Age of maximum ferritin level (y)9.7 ± 2.4 (5.3–13.8)
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Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine