<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Cardiovascular disease is the largest cause of morbidity and mortality in patients with type 2 diabetes mellitus. Interestingly, previous studies demonstrated that type 2 diabetic patients had a significantly higher concentration of 8-Hydroxydeoxyguanosine (8-OHdG) although it role in the pathogenesis of carotid artery atheroma and insulin resistance has not been identified.Objective: We investigated the role of serum 8-OHdG levels in the intima-media thickness (IMT) of the carotid artery, and its significance in insulin resistance in type 2 diabetes.Methods: Fifty patients with disease-onset type 2 diabetes were enrolled and divided into two groups according to the intima-media thickness of the carotid artery (&lt;1.0 mm = group A or ≥1.0 mm = group B). Blood samples from patients were used within one month for the determination of 8-OHdG using a competitive ELISA kit, and other coronary heart disease (CHD) risk factors were also measured.Results: Patients in Group B showed significant higher levels of serum 8-OHdG compared to that of group A and control. Serum 8-OHdG had significant positive correlations with BMI, SBP, FPG, FINS, HbA1c, TC, and Homa-IR. Similarly, a significant positive correlation existed between the serum 8-OHdG and IMT levels. 8-OHdG, Homa-IR, HbA1c and TC were independently associated with increased IMT in type 2 diabetes patients.Conclusion: Serum 8-OHdG is a useful indicator for the severity of IMT of the carotid artery and reflects the severity of insulin resistance in type 2 diabetes.</abstract>

Background: Cardiovascular disease is the largest cause of morbidity and mortality in patients with type 2 diabetes mellitus. Interestingly, previous studies demonstrated that type 2 diabetic patients had a significantly higher concentration of 8-Hydroxydeoxyguanosine (8-OHdG) although it role in the pathogenesis of carotid artery atheroma and insulin resistance has not been identified.Objective: We investigated the role of serum 8-OHdG levels in the intima-media thickness (IMT) of the carotid artery, and its significance in insulin resistance in type 2 diabetes.Methods: Fifty patients with disease-onset type 2 diabetes were enrolled and divided into two groups according to the intima-media thickness of the carotid artery (<1.0 mm = group A or ≥1.0 mm = group B). Blood samples from patients were used within one month for the determination of 8-OHdG using a competitive ELISA kit, and other coronary heart disease (CHD) risk factors were also measured.Results: Patients in Group B showed significant higher levels of serum 8-OHdG compared to that of group A and control. Serum 8-OHdG had significant positive correlations with BMI, SBP, FPG, FINS, HbA1c, TC, and Homa-IR. Similarly, a significant positive correlation existed between the serum 8-OHdG and IMT levels. 8-OHdG, Homa-IR, HbA1c and TC were independently associated with increased IMT in type 2 diabetes patients.Conclusion: Serum 8-OHdG is a useful indicator for the severity of IMT of the carotid artery and reflects the severity of insulin resistance in type 2 diabetes.

Significance of serum 8-Hydroxydeoxyguanosine levels to the intima-media thickness of the carotid artery in type 2 diabetes

Department of Endocrinology and Metabolism, Suzhou City, Jiangsu 215006,

Department of Endocrinology and Metabolissm, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006,

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu 215006,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background: Cardiovascular disease is the largest cause of morbidity and mortality in patients with type 2 diabetes mellitus. Interestingly, previous studies...

Significance of serum 8-Hydroxydeoxyguanosine levels to the intima-media thickness of the carotid artery in type 2 diabetes

Article Category: Brief communication (Original)

Pubblicato online: 04 feb 2017

Pagine: 759 - 764

DOI: https://doi.org/10.5372/1905-7415.0605.118

Parole chiave
Carotid artery, insulin resistance, intima-media thickness, type 2 diabetes, 8-hydroxydeoxyguanosine

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Significance of serum 8-Hydroxydeoxyguanosine levels to the intima-media thickness of the carotid artery in type 2 diabetes

Article Category: Brief communication (Original)

Pubblicato online: 04 feb 2017

Pagine: 759 - 764

DOI: https://doi.org/10.5372/1905-7415.0605.118

Parole chiaveCarotid artery, insulin resistance, intima-media thickness, type 2 diabetes, 8-hydroxydeoxyguanosine

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Parole chiave
Carotid artery, insulin resistance, intima-media thickness, type 2 diabetes, 8-hydroxydeoxyguanosine