The expression of human epididymis protein 4 and cyclindependent kinase inhibitor p27Kip1 in human ovarian carcinoma

1. Ries LAG, Kosary CL, Hankey BF, Miller BA, Clegg L, Edwards BK. SEER Cancer Statistics Review. National Cancer Institute. 1973-1998.Search in Google Scholar

2. Bast RC Jr, Feeney M, Lazarus H, Nadler LM, Colvin RB, Knapp RC. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest, 1981; 68: 1331-7.10.1172/JCI110380Open DOISearch in Google Scholar

3. Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR. The whey acidic protein family: a new signature motif and threedimensional structure by comparative modelling. J Mol Graph Model. 1999; 17:106-13.10.1016/S1093-3263(99)00023-6Open DOISearch in Google Scholar

4. Schalkwijk J, Wiedow O, Hirose S. The trappin gene family: proteins defined by an N terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Biochem J. 1999; 340:569-77.10.1042/bj3400569Search in Google Scholar

5. Hellström I, Raycraft J, Hayden-Ledbetter M, Ledbetter JA, Schummer M, Drescher C, et al. The HE4 (WFDC2) Protein is a biomarker for ovarian carcinoma. Cancer Res. 2003; 63:3695-700.Search in Google Scholar

6. Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature. 1998; 396:177-80.10.1038/24179Search in Google Scholar

7. Lee MH, Reynisdottir I, Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 1995; 9:639-49.10.1101/gad.9.6.639Open DOISearch in Google Scholar

8. Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, et al. Cloning of p27Kip1, a cyclindependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994; 78:59-66.10.1016/0092-8674(94)90572-XOpen DOISearch in Google Scholar

9. Catzavelos C, Bhattacharya N, Ung YC, Wilson JA, Roncari L, Sandhu C, et al. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nat Med. 1997; 3:227-30.10.1038/nm0297-2279018244Open DOISearch in Google Scholar

10. Porter PL, Malone KE, Heagerty PJ, Alexander GM, Gatti LA, Firpo EJ, et al. Expression of cell cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med.1997; 3:222-5.10.1038/nm0297-2229018243Open DOISearch in Google Scholar

11. Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Millard SS, et al. Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. J Natl Cancer Inst. 1998; 90:1284-91.10.1093/jnci/90.17.12849731735Open DOISearch in Google Scholar

12. Sui L, Dong Y, Ohno M, Sugimoto K, Tai Y, Hando T, et al. Implication of malignancy and prognosis of p27kip1, cyclin E, and cdk2 expression in epithelial ovarian tumors. Gynecol Oncol. 2001; 83:56-63.10.1006/gyno.2001.630811585414Open DOISearch in Google Scholar

13. Mori M, Mimori K, Shiraishi T, Tanaka S, Ueo H, Sugimachi K, et al. p27 expression and gastric carcinoma. Nat Med. 1997; 3:593.10.1038/nm0697-593Open DOISearch in Google Scholar

14. Xu X, Yamamoto H, Sakon M, Yasui M, Ngan, CY, Fukunaga H, et al. Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas. Clin Cancer Res. 2003; 9:1764-72.Search in Google Scholar

15. Fero ML, Randel E, Gurley KE, Roberts JM and Kemp CJ. The murine gene p27Kip1 is haploinsufficient for tumour suppression. Nature. 1998; 396: 177-80.10.1038/24179Search in Google Scholar

16. Lee MH, Reynisdottir I and Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 1995; 9:639-49.10.1101/gad.9.6.639Open DOISearch in Google Scholar

17. Bingle L, Singleton V, Bingle CD. The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. Oncogene. 2002; 21:2768-73.10.1038/sj.onc.1205363Open DOISearch in Google Scholar

18. Hayden MS, Gilliland LK, Ledbetter JA. Antibody engineering. Curr Opin Immunol. 1997; 9:201-12.10.1016/S0952-7915(97)80136-7Open DOISearch in Google Scholar

19. Bali A, O’Brien PM, Edwards LS, Sutherland RL, Hacker NF, Henshall SM, et al. Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer. Clin Cancer Res. 2004; 10:5168-77.10.1158/1078-0432.CCR-03-075115297421Search in Google Scholar

20. Gopfert U, Kullmann M, Hengst L. Cell cycledependent translation of p27 involves a responsive element in its 50-UTR that overlaps with a uORF. Hum Mol Genet. 2003; 12:1767-79.10.1093/hmg/ddg17712837699Open DOISearch in Google Scholar

21. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995; 269:682-5.10.1126/science.76247987624798Search in Google Scholar

22. Malek NP, Sundberg H, McGrew S, Nakayama K, Kyriakidis TR, Roberts JM. A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature. 2001; 413:323-7.10.1038/3509508311565035Search in Google Scholar

23. Hara T, Kamura T, Nakayama K, Oshikawa K, Hatakeyama S, Nakayama KI. Degradation of p27Kip1 at the G0-G1 transition mediated by a Skp2-independent ubiquitination pathway. J Biol Chem. 2001; 276: 48937-43.10.1074/jbc.M10727420011682478Open DOISearch in Google Scholar

24. Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 2001; 20:6672-82.10.1093/emboj/20.23.667212577311726503Open DOISearch in Google Scholar

25. Hara T, Kamura T, Kotoshiba S, Takahashi H, Fujiwara K, Onoyama I, Shirakawa M, Mizushima N, Nakayama KI. Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Mol. Cell. Biol. 2005; 25:9292-303.10.1128/MCB.25.21.9292-9303.2005126580816227581Open DOISearch in Google Scholar

26. Besson A, Gurian-West M, Chen X, Kelly-Spratt KS, Kemp CJ, Roberts JM. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev. 2006; 20:47-64.10.1101/gad.1384406135610016391232Open DOISearch in Google Scholar

27. Kamura T, Hara T, Matsumoto M, Ishida N, Okumura F, Hatakeyama S, et al. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol. 2004; 6:1229-35.10.1038/ncb119415531880Open DOISearch in Google Scholar

28. Ishida N, Hara T, Kamura T, Yoshida M, Nakayama K, Nakayama KI. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem. 2002; 277:14355-8. 10.1074/jbc.C10076220011889117Open DOISearch in Google Scholar