[1. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest. 2002; 110: 1839-47.10.1172/JCI200216857]Search in Google Scholar
[2. Sussel L, Kalamaras J, Hartigan OCDJ, Meneses JJ, Pedersen RA, Rubenstein JL, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998; 125:2213-21.10.1242/dev.125.12.2213]Search in Google Scholar
[3. Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, et al. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of betacell formation in the pancreas. Development. 2000; 127: 5533-40.10.1242/dev.127.24.5533]Search in Google Scholar
[4. Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, et al. The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol. 2004; 266:178-89.10.1016/j.ydbio.2003.10.018]Search in Google Scholar
[5. Kawamori D, Kaneto H, Nakatani Y, Matsuoka TA, Matsuhisa M, Hori M, et al. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem. 2006; 281:1091-8.10.1074/jbc.M508510200]Search in Google Scholar
[6. Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, et al. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005; 289:E337-46.10.1152/ajpendo.00032.2004]Search in Google Scholar
[7. Wither DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998; 391:900-4.10.1038/36116]Search in Google Scholar
[8. Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 1999; 96:329-39.10.1016/S0092-8674(00)80546-2]Search in Google Scholar
[9. Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, et al. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest. 2003; 112:1521-32.10.1172/JCI18581]Search in Google Scholar
[10. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell. 1999; 96:857-68.10.1016/S0092-8674(00)80595-4]Search in Google Scholar
[11. Zhang XF, Zhang JJ, Yang XM, Han X. Several transcription factors regulate COX-2 gene expression in pancreatic -cells. Mol Biol Rep. 2007; 34: 199-206.10.1007/s11033-007-9085-317505916]Search in Google Scholar
[12. Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS. Defining the CREB regulon: a genomewide analysis of transcription factor regulatory regions. Cell. 2004; 119:1041-54.]Search in Google Scholar
[13. Maiese K, Chong ZZ, Shang YC. OutFOXOing disease and disability: The therapeutic potential of targeting FoxO proteins. Trends Mol Med. 2008; 14:219-27.10.1016/j.molmed.2008.03.002257215018403263]Search in Google Scholar
[14. Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem. 1999; 274:17184-92.10.1074/jbc.274.24.1718410358076]Search in Google Scholar
[15. Nakae J, Park BC, Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem. 1999; 274:15982-5.10.1074/jbc.274.23.1598210347145]Search in Google Scholar
[16. Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, et al. Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, downregulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem. 2004; 279: 41114-23.10.1074/jbc.M40067420015272020]Search in Google Scholar
[17. Zhang X, Yong W, Lv J, Zhu Y, Zhang J, Chen F, et al. Inhibition of forkhead box O1 protects pancreatic betacells against dexamethasone-induced dysfunction. Endocrinology. 2009; 150: 4065-73.10.1210/en.2009-034319443572]Search in Google Scholar
[18. Cardenas C, Muller M, Jaimovich E. Carrasco Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase Calpha. J Biol Chem. 2004; 279:39122-31.10.1074/jbc.M40104420015262987]Search in Google Scholar
[19. Wu GY, Deisseroth K, Tsien RW. Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA. 2001; 98:2808-13.10.1073/pnas.0516341983022111226322]Search in Google Scholar
[20. Togo T. Long-term potentiation of wound-induced exocytosis and plasma membrane repair is dependent on cAMP-response element-mediated transcription via a protein kinase C- and p38 MAPK-dependent pathway. J Biol Chem. 2004; 279:44996-5003.10.1074/jbc.M40632720015317814]Search in Google Scholar
[21. Mitsuru O, Dennis JC, Roxana MM, Amilcar FM, Terry GU, Peter R. Signal transducer and activator of transcription (Stat) 5b-mediated inhibition of insulinlike growth factor binding protein-1 gene transcription: a mechanism for repression of gene expression by growth hormone. Mol Endocrinol. 2007; 21: 1443-57.10.1210/me.2006-054317426286]Search in Google Scholar
[22. Sharrocks AD, Brown AL, Ling Y. The ETS-domain transcription factor family. Int J Biochem Cell Biol. 1997; 29:1371-87.10.1016/S1357-2725(97)00086-1]Search in Google Scholar
[23. Buchwalter G, Gross C, Wasylyk B. Ets ternary complex transcription factors. Gene. 2004; 324:1-14.10.1016/j.gene.2003.09.02814693367]Search in Google Scholar
[24. Kasza A, O’Donnell A, Gascoigne K, Zeef LA, Hayes A, Sharrocks AD. The ETS domain transcription factor Elk-1 regulates the expression of its partner protein, SRF. J Biol Chem. 2005; 280:1149-55.10.1074/jbc.M41116120015531578]Search in Google Scholar