<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Objectives</h3><p>We aimed to evaluate the effects of chronic exposure to bisphenol A (BPA) on atrial fibrillation (AF) occurrence in rats.</p></sec>
<sec><h3>Methods</h3><p>Twenty-two healthy female Wistar rats were randomized into three groups: Control (no BPA; n=7), BPA (exposed to usual BPA doses; 50 μg/kg/day, 9 weeks; n=7), and hBPA (exposed to high BPA doses; 25 mg/kg/day, 9 weeks; n=8). 24-h ECG monitoring was performed using radiotelemetry ECG devices prior to and after transesophageal atrial pacing. Spontaneous and pacing-induced atrial arrhythmias, autonomic tone, and <italic>in vivo</italic> an <italic>in vitro</italic> atrial arrhythmogenicity-related parameters were evaluated.</p></sec>
<sec><h3>Results</h3><p>All studied parameters were similar between Control and BPA (all p>0.05). However, compared to Control, hBPA presented more atrial premature beats both at baseline (p=0.04) and after pacing (p=0.03), more AF episodes (p&lt;0.001) and of longer duration (p=0.02) following transesophageal stimulation, and significantly higher vagal tone (all p&lt;0.05).</p></sec>
<sec><h3>Conclusions</h3><p>Chronic exposure to high, but not usual BPA doses induced significant atrial proarrhythmic effects in healthy rats, and this may be at least partially due to BPA-induced vagal hyperactivation. Exposure to high BPA doses, such as that occurring in plastics industry workers, could favor AF occurrence even in the absence of underlying cardiovascular disease.</p></sec>
</abstract>

ObjectivesWe aimed to evaluate the effects of chronic exposure to bisphenol A (BPA) on atrial fibrillation (AF) occurrence in rats.
MethodsTwenty-two healthy female Wistar rats were randomized into three groups: Control (no BPA; n=7), BPA (exposed to usual BPA doses; 50 μg/kg/day, 9 weeks; n=7), and hBPA (exposed to high BPA doses; 25 mg/kg/day, 9 weeks; n=8). 24-h ECG monitoring was performed using radiotelemetry ECG devices prior to and after transesophageal atrial pacing. Spontaneous and pacing-induced atrial arrhythmias, autonomic tone, and in vivo an in vitro atrial arrhythmogenicity-related parameters were evaluated.
ResultsAll studied parameters were similar between Control and BPA (all p>0.05). However, compared to Control, hBPA presented more atrial premature beats both at baseline (p=0.04) and after pacing (p=0.03), more AF episodes (p<0.001) and of longer duration (p=0.02) following transesophageal stimulation, and significantly higher vagal tone (all p<0.05).
ConclusionsChronic exposure to high, but not usual BPA doses induced significant atrial proarrhythmic effects in healthy rats, and this may be at least partially due to BPA-induced vagal hyperactivation. Exposure to high BPA doses, such as that occurring in plastics industry workers, could favor AF occurrence even in the absence of underlying cardiovascular disease.

Chronic Exposure to High Doses of Bisphenol A Exhibits Significant Atrial Proarrhythmic Effects in Healthy Adult Rats

„George Emil Palade” University of Medicine, Pharmacy, Science and Technology

Emergency Institute for Cardiovascular Diseases and Transplantation

Romanian Journal of Cardiology

This work is licensed under the Creative Commons Attribution 4.0 International License.

ObjectivesWe aimed to evaluate the effects of chronic exposure to bisphenol A (BPA) on atrial fibrillation (AF) occurrence in rats.
MethodsTwenty-two healthy...

Chronic Exposure to High Doses of Bisphenol A Exhibits Significant Atrial Proarrhythmic Effects in Healthy Adult Rats

Article Category: Original Article

Pubblicato online: 05 mag 2022

Pagine: 587 - 595

DOI: https://doi.org/10.47803/rjc.2021.31.3.587

Parole chiave
atrial fibrillation, bisphenol A, heart rate variability, vagal hyperactivation

© 2021 Vasile Bogdan Halatiu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Chronic Exposure to High Doses of Bisphenol A Exhibits Significant Atrial Proarrhythmic Effects in Healthy Adult Rats

Article Category: Original Article

Pubblicato online: 05 mag 2022

Pagine: 587 - 595

DOI: https://doi.org/10.47803/rjc.2021.31.3.587

Parole chiaveatrial fibrillation, bisphenol A, heart rate variability, vagal hyperactivation

© 2021 Vasile Bogdan Halatiu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Parole chiave
atrial fibrillation, bisphenol A, heart rate variability, vagal hyperactivation